Vaxcyte Inc's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of Vaxcyte Inc (PCVX) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
Key Findings: Vaxcyte Inc vs Its Competitors
- Scale: Vaxcyte Inc ranks #14 of 165 companies by market capitalization in the Biotechnology & Pharmaceuticals industry, holding 1.0% of industry market cap.
Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).
API endpoints for this dataset
Vaxcyte Inc's Competitor Quality Breadth
Group definitions: see Methodology: Performance Group Definitions.
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| Vaxcyte Inc | - | - | - | Yes |
| Competitors combined (27) | ||||
| High-Confidence Competitors (6) | ||||
| Similar-Size Competitors (9) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
PCVX Stock Performance relative to its Competitors
PCVX Stock Performance relative to High-Confidence Competitors
PCVX Stock Performance relative to Similar-Size Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Moderna Inc | 282.9% | Outperformed |
| 2 | Immunitybio inc | 282.9% | Outperformed |
| 3 | Tourmaline Bio Inc | 282.9% | Outperformed |
| 4 | Alector Inc | 282.9% | Outperformed |
| 5 | Merck and Co Inc | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for Vaxcyte Inc's best-performing competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Vaxcyte Inc's Comment on Competition and Industry Peers
Publicly Traded Peers of Vaxcyte Inc
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
 Vaxcyte Inc |
9,757.69 | - |
 Merck and Co Inc |
367,313.70 | 66,569.00 |
 Pfizer Inc |
168,101.73 | 63,625.00 |
 Sanofi |
117,951.74 | 49,307.90 |
 Moderna Inc |
107,062.00 | 2,228.00 |
 Gsk Plc |
106,095.09 | 43,093.89 |
| SUBTOTAL | 924,935.14 | 229,247.86 |
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Sources: see Methodology: Peer & Competitor Identification, Sourcing.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Vaxcyte Inc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
Vaxcyte Inc's Competitors Named by the Company
Competitive relationships identified from Vaxcyte Inc reports and corroborating sources, each with a basis and confidence.| Competitor | Basis | Confidence |
|---|---|---|
| Pfizer | Company report | 85% |
| Merck | Company report | 85% |
| GSK | Company report | 85% |
| Sanofi | Company report | 85% |
| Moderna | Company report | 85% |
| GSK Vaccines Institute for Global Health | Company report | 85% |
| Sutro Biopharma | Company report | 85% |
| Cortexyme | Company report | 85% |
| Novavax inc | Company report | 85% |
| Icosavax Inc | Company report | 85% |
| Biontech Se | Company report | 85% |
| Vaxart Inc | Company report | 85% |
Company report basis, confidence, active dates and source counts for Vaxcyte Inc's named competitors require a Commercial License.
Methodology: see Methodology: Peer & Competitor Identification, Sourcing.
Vaxcyte Inc's Business Segment Mix vs Peers
Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).| Company | Largest Segment |
|---|---|
| Merck and Co Inc | Pharmaceutical segment 89.95 % |
| Pfizer Inc | U.S. Commercial Division 58.35 % |
| Immunitybio inc | Reportable 100.00 % |
| Novavax inc | Reportable 100.00 % |
| Armata Pharmaceuticals Inc | Single Reportable Segment 100.00 % |
Source: operating segment revenue as reported in each company's reports (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).
Vaxcyte Inc's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| Vaxcyte Inc | 9,758 | - | -2,099,134 |
| Merck and Co Inc | 367,314 | 887,587 | 42,267 |
| Pfizer Inc | 168,102 | 848,333 | 54,160 |
| Sanofi | 117,952 | 21,607,316 | 3,889,794 |
| Moderna Inc | 107,062 | 474,043 | -670,426 |
| Gsk Plc | 106,095 | 169,660,977 | 32,662,867 |
| PEERS TOTAL | 915,177 | 1,362,357 | 104,888 |
Vaxcyte Inc's Geographic Revenue Exposure vs Peers
Revenue by country/region as reported in each company's most recent report. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.| Company | Largest Market |
|---|---|
| Merck and Co Inc | EMEA 21.50 % |
| Pfizer Inc | United States 63.93 % |
| Immunitybio inc | United States 99.79 % |
| Novavax inc | United States 68.88 % |
Source: revenue geography as reported in each company's reports (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.
Vaxcyte Inc's Position in Industry Market Structure
Market-capitalization share and concentration across all 157 companies in Vaxcyte Inc's industry classification, broader than the peer set above. Market cap in millions of $.Vaxcyte Inc ranks #14 of 157 companies by market capitalization in its industry, holding 1.01 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 1,388, indicating a unconcentrated market structure (see Methodology: Market Structure & Concentration).
| Rank | Company | Market Cap | Industry Share |
|---|---|---|---|
| 1 | Amgen Inc | 253,085 | 26.21 % |
| 2 | Gilead Sciences Inc | 210,465 | 21.80 % |
| 3 | Moderna Inc | 107,062 | 11.09 % |
| 4 | Argenx Se | 63,538 | 6.58 % |
| 5 | Revolution Medicines Inc | 1,234 | 5.2% |
| 6 | Biogen Inc | 1,234 | 5.2% |
| 7 | Biontech Se | 1,234 | 5.2% |
| 8 | Exelixis Inc | 1,234 | 5.2% |
| 9 | Neurocrine Biosciences Inc | 1,234 | 5.2% |
| 10 | Kymera Therapeutics Inc | 1,234 | 5.2% |
| 14 | Vaxcyte Inc | 9,758 | 1.01 % |
Market cap and industry share for the rest of Vaxcyte Inc's industry peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2026-11-09.
Vaxcyte Inc's Same-Size Peers & Stock Performance
Peers chosen by closeness in market-cap rank within the same industry classification (not the named-competitor list above). Trailing 12-month total return, 3-month price momentum, beta and Sharpe ratio vs the broad U.S. market.| Rank | Company | Market Cap | TTM Return |
|---|---|---|---|
| 9 | Neurocrine Biosciences Inc | 17,595 | 5.92 % |
| 10 | Kymera Therapeutics Inc | 13,633 | 114.14 % |
| 11 | Halozyme Therapeutics Inc | 12,475 | 51.22 % |
| 12 | Qiagen N v | 11,064 | 17.44 % |
| 13 | Repligen Corp | 1,234 | 12.3% |
| 14 | Vaxcyte Inc | 9,758 | 54.45 % |
| 15 | Krystal Biotech Inc | 1,234 | 12.3% |
| 16 | Twist Bioscience Corporation | 1,234 | 12.3% |
| 18 | Immunitybio inc | 1,234 | 12.3% |
| 19 | Scholar Rock Holding Corp | 1,234 | 12.3% |
Market cap, return, momentum, beta and Sharpe ratio for the rest of Vaxcyte Inc's same-size peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation); returns and risk metrics as of 2026-11-09. Beta and Sharpe ratio are versus the broad U.S. equity market, not this industry.
Vaxcyte Inc's Valuation vs Competitive Position
Valuation multiples vs the Biotechnology & Pharmaceuticals industry average (159 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns. See the full Biotechnology & Pharmaceuticals industry valuation benchmarks.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 26.5x | - |
| EV / EBITDA | - | 16.7x | - |
| P/B | 2.8x | 5.1x | -2.3x |
| Return on Equity | -37.57 % | industry aggregate | -36.03 % |
| Return on Invested Capital | -21.05 % | -10.87 % (avg) | -10.18 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
Vaxcyte Inc's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in company reports.| Metric | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|
| Revenue Growth | - | - | - | - | - | - |
| Operating Margin | - | - | - | - | - | - |
| Return on Invested Capital | - | -16.72 % | -22.47 % | -18.55 % | -10.59 % | -16.35 % |
| P/E | - | - | - | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
Vaxcyte Inc's BCG Growth-Share Matrix
See Methodology: BCG Growth-Share Matrix for how relative share and growth are calculated and thresholded.
Vaxcyte Inc falls in the Dog quadrant: relative market share of 0.04x vs its largest competitor, in an industry growing revenue 8.5% (median, trailing 12 months).
Source: CSIMarket API (market-cap share and industry revenue growth). The 10% growth and 1.0x share lines are standard textbook thresholds, not derived from this industry's own distribution.
Vaxcyte Inc's Competitive Forces (Porter's Five Forces)
Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.| Force | Assessment | Basis |
|---|---|---|
| Competitive Rivalry | High | Industry HHI of 1,388 (see Industry Market Structure & Concentration above) |
Note: see Methodology: Porter's Five Forces. Supplier power and buyer power are covered on Vaxcyte Inc's dedicated Suppliers and Customers pages, not here.
Vaxcyte Inc's Industry Attractiveness & Competitive Strength
See Methodology: GE/McKinsey Matrix for how the two axes are built.
Vaxcyte Inc falls in the Low attractiveness / Low strength cell: Harvest / Divest.
Source: CSIMarket API, trailing 12 months. Each axis score is a simple 1(low)/2(medium)/3(high) average across its three inputs -- a transparent, disclosed simplification, not a validated academic scoring model.
Vaxcyte Inc's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
- Outperforming the U.S.A. 500 over the trailing 12 months.
Weaknesses
- Return on equity 36.0 points below the industry aggregate.
- Low relative market share vs the industry leader (0.04x).
- Piotroski F-Score of 2 or below, the standard financial-distress signal.
Opportunities
- A meaningful share of competitors (55.60 %) show financial-distress signals, a possible opening to gain share.
Threats
- Tracked peer group's revenue run-rate is broadly decelerating (-4.3% annualized).
Methodology: see Methodology: SWOT Analysis.
Vaxcyte Inc's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| Vaxcyte Inc | 0.98 | 7.36 | - |
| Merck and Co Inc | 0.40 | 1.46 | 1.01 |
| Pfizer Inc | 0.04 | 1.27 | 0.72 |
| Sanofi | 0.27 | 1.09 | 0.20 |
| Moderna Inc | 0.86 | 2.88 | 0.07 |
| Gsk Plc | 0.16 | 0.82 | 0.87 |
Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
Vaxcyte Inc's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| Vaxcyte Inc | Q2 2026 | - | - |
| Merck and Co Inc | Q2 2026 | +5.1 % | - |
| Pfizer Inc | Q3 2026 | -0.4 % | -8.7 % |
| Sanofi | Q4 2025 | +10.9 % | +46.0 % |
| Moderna Inc | Q2 2026 | +2.1 % | - |
| Gsk Plc | Q4 2025 | +7.5 % | +120.0 % |
| PEERS TOTAL | +7.5 % | +4.1 % |
Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
Vaxcyte Inc's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| Vaxcyte Inc | Q2 2026 | - | +138.5 % |
| Merck and Co Inc | Q2 2026 | +23.6 % | +16.9 % |
| Pfizer Inc | Q3 2026 | -3.5 % | -4.8 % |
| Sanofi | Q4 2025 | +9.3 % | - |
| Moderna Inc | Q2 2026 | -21.8 % | +1,133.3 % |
| Gsk Plc | Q4 2025 | +7.2 % | -0.6 % |
Vaxcyte Inc's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| Vaxcyte Inc | - | - | - |
| Merck and Co Inc | 2.42% | 3.24% | 6.59% |
| Pfizer Inc | 1.98% | 2.34% | 4.62% |
| Sanofi | 5.96% | 8.19% | 10.55% |
| Moderna Inc | - | - | - |
| Gsk Plc | 10.09% | 44.94% | 38.67% |
ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
Vaxcyte Inc's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| Vaxcyte Inc | - | - |
| Merck and Co Inc | 119.93 | 5.52 |
| Pfizer Inc | 41.60 | 2.64 |
| Sanofi | 13.36 | 2.39 |
| Moderna Inc | - | 48.05 |
| Gsk Plc | 14.07 | 2.46 |
| PEERS AVERAGE | 55.77 | 4.03 |
P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.