Sage Therapeutics Inc's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of Sage Therapeutics Inc (SAGE) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
Key Findings: Sage Therapeutics Inc vs Its Competitors
- TTM: Trailing 12-month revenue of 70M vs 279,044M combined for its competitors (0.0% combined share).
- Trending: Latest-quarter revenue run-rate is accelerating (+79.9% annualized vs trailing 12 months), vs decelerating (-12.7%) for its tracked peer group.
- Growth: Sage Therapeutics Inc generated 265.8% revenue growth year over year in Q2 2025, vs 12.3% for its competitors combined.
- Profitability: Its -156.8% net margin compares with 13.7% for the peer group.
- Peer revenue share: Sage Therapeutics Inc accounted for 0.1% of combined revenue among its tracked peer group, up from 0.0% a year earlier.
- Peer differentiation: Revenue per employee of $0.20M compares with $1.20M for the peer group (0.2x).
Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).
SAGE Sales vs. its Competitors, Q2 2025
Sage Therapeutics Inc reported revenue growth of 265.84 % year on year in Q2 2025, above its competitors' combined revenue growth of 12.31 %.
With a net margin of -156.83 %, Sage Therapeutics Inc reported lower profitability than its competitors (13.71 %).
Sage Therapeutics Inc generated 0.05 % of the combined sales of its peer group, up from 0.02 % a year earlier.
API endpoints for this dataset
Sage Therapeutics Inc vs. its Competitors, Q2 2025
Revenue growth, year on year
Net margin
Revenue run-rate vs trailing 12 months
TTM net margin
TTM = trailing twelve months. Run-rate annualizes the latest quarter (×4) and compares it to TTM. In millions of $. High-Confidence Competitors are named as a competitor directly in Sage Therapeutics Inc reports; Similar-Size Competitors are the closest peers by market-cap rank within the same industry; Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC, all independent of the competitor list.
TTM revenue, latest-quarter run-rate and net income/margin benchmarked across Sage Therapeutics Inc and its 4 competitor groupings. Available under Commercial License.
| Entity | TTM Revenue | Rev Run-rate vs TTM |
|---|---|---|
| Sage Therapeutics Inc | $12,345M | +12.3% · Accelerating |
| Competitors combined | $12,345M | +12.3% · Accelerating |
| High-Confidence Competitors (10) | $12,345M | +12.3% · Accelerating |
TTM revenue, run-rate and net margin benchmarking across Sage Therapeutics Inc's competitor groups requires a Commercial License.
For context: the Major Pharmaceutical Preparations industry grew revenue 8.9% year over year, combined, vs 265.8% for Sage Therapeutics Inc. Sage Therapeutics Inc's share of combined industry revenue moved from 0.00% to 0.01%, a gain of 0.00 percentage points.
Sage Therapeutics Inc's Competitor Quality Breadth
Group definitions: see Methodology: Performance Group Definitions.
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| Sage Therapeutics Inc | - | No | No | Yes |
| Competitors combined (104) | ||||
| High-Confidence Competitors (14) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
SAGE Stock Performance relative to its Competitors
SAGE Stock Performance relative to High-Confidence Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Ventyx Biosciences Inc | 282.9% | Outperformed |
| 2 | Climb Bio Inc | 282.9% | Outperformed |
| 3 | Gossamer Bio Inc | 282.9% | Outperformed |
| 4 | Damora Therapeutics Inc | 282.9% | Outperformed |
| 5 | Definium Therapeutics Inc | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for Sage Therapeutics Inc's best-performing competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Publicly Traded Peers of Sage Therapeutics Inc
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
 Sage Therapeutics Inc |
543.46 | 70.41 |
 Eli Lilly And Company |
1,209,663.60 | 86,462.00 |
 Abbvie Inc |
516,201.32 | 66,014.00 |
 Amgen Inc |
250,468.48 | 38,095.00 |
 Vertex Pharmaceuticals Inc |
139,617.37 | 12,951.60 |
 Teva Pharmaceutical Industries Limited |
50,407.63 | 14,020.00 |
| SUBTOTAL | 2,445,817.17 | 280,039.95 |
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Sources: see Methodology: Peer & Competitor Identification, Sourcing.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Sage Therapeutics Inc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
Sage Therapeutics Inc's Competitors Named by the Company
Competitive relationships identified from Sage Therapeutics Inc reports and corroborating sources, each with a basis and confidence.| Competitor | Basis | Confidence |
|---|---|---|
| Ovid Therapeutics Inc | Company report | 85% |
| Praxis Precision Medicines Inc | Company report | 85% |
| Freshworks Inc | Company report | 85% |
| Thomson Reuters Corporation | Company report | 85% |
| Bright Minds Biosciences Inc | Company report | 85% |
| Crown Electrokinetics Corp | Company report | 85% |
| Marinus Pharmaceuticals, Inc. | Company report | 85% |
| MNMD | Company report | 85% |
| Cerevel Therapeutics, Inc. | Company report | 85% |
| Definium Therapeutics Inc | Company report | 85% |
| Lipocine, Inc. | Company report | 85% |
| Puretech Health Plc | Company report | 85% |
| Intuit Inc | Company report | 85% |
| Upsher-Smith Laboratories | Company report | 85% |
| Aptinyx Inc. | Company report | 85% |
| Vistagen Therapeutics Inc | Company report | 85% |
| Abbvie Inc | Company report | 85% |
| Protagenic Therapeutics Inc new | Company report | 85% |
| Amneal Pharmaceuticals Inc | Company report | 85% |
| Serina Therapeutics Inc | Company report | 85% |
| Zevra Therapeutics Inc | Company report | 85% |
| Harmony Biosciences Holdings inc | Company report | 85% |
| Neurocrine Biosciences Inc | Company report | 85% |
| Intra cellular Therapies Inc | Company report | 85% |
| Seelos Therapeutics inc | Company report | 85% |
| Karuna Therapeutics Inc | Company report | 85% |
| Acadia Pharmaceuticals Inc | Company report | 85% |
| Reunion Neuroscience Inc | Company report | 85% |
| Biogen Inc | Company report | 85% |
| Vanda Pharmaceuticals Inc | Company report | 85% |
| Eli Lilly And Company | Company report | 85% |
| Compass Pathways Plc | Company report | 85% |
| Jazz Pharmaceuticals Plc | Company report | 85% |
| Alkermes Plc | Company report | 85% |
| Axsome Therapeutics Inc | Company report | 85% |
| Collegium Pharmaceutical Inc | Company report | 85% |
| Neuraxis Inc | Company report | 85% |
Company report basis, confidence, active dates and source counts for Sage Therapeutics Inc's named competitors require a Commercial License.
Methodology: see Methodology: Peer & Competitor Identification, Sourcing.
Sage Therapeutics Inc's Business Segment Mix vs Peers
Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).| Company | Largest Segment |
|---|---|
| Eli Lilly And Company | Reportable 100.00 % |
| Amgen Inc | Reportable 100.00 % |
| Vertex Pharmaceuticals Inc | Pharmaceuticals 100.00 % |
| Teva Pharmaceutical Industries Limited | United States 42.55 % |
| Biogen Inc | Reportable 100.00 % |
Source: operating segment revenue as reported in each company's reports (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).
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Sage Therapeutics Inc's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| Sage Therapeutics Inc | 543 | 199,462 | -853,244 |
| Eli Lilly And Company | 1,209,664 | 1,729,240 | 551,594 |
| Abbvie Inc | 516,201 | 1,158,140 | 181,509 |
| Amgen Inc | 250,468 | 2,930,385 | 672,538 |
| Vertex Pharmaceuticals Inc | 139,617 | 31,979,259 | 9,817,037 |
| Teva Pharmaceutical Industries Limited | 50,408 | 412,960 | 14,963 |
| PEERS TOTAL | 2,445,274 | 1,197,275 | 195,470 |
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Sage Therapeutics Inc's Geographic Revenue Exposure vs Peers
Revenue by country/region as reported in each company's most recent report. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.| Company | Largest Market |
|---|---|
| Eli Lilly And Company | United States 62.04 % |
| Vertex Pharmaceuticals Inc | United States 63.04 % |
| Teva Pharmaceutical Industries Limited | Europe 30.49 % |
| Jazz Pharmaceuticals Plc | United States 88.39 % |
| Aquestive Therapeutics Inc | United States 60.98 % |
Source: revenue geography as reported in each company's reports (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.
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Sage Therapeutics Inc's Position in Industry Market Structure
Market-capitalization share and concentration across all 495 companies in Sage Therapeutics Inc's industry classification, broader than the peer set above. Market cap in millions of $.Sage Therapeutics Inc ranks #0 of 495 companies by market capitalization in its industry, holding 0.00 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 875, indicating a unconcentrated market structure (see Methodology: Market Structure & Concentration).
| Rank | Company | Market Cap | Industry Share |
|---|---|---|---|
| 1 | Eli Lilly And Company | 1,210,070 | 20.69 % |
| 2 | Johnson and Johnson | 674,004 | 11.53 % |
| 3 | Beone Medicines Ltd | 612,622 | 10.48 % |
| 4 | Abbvie Inc | 515,910 | 8.82 % |
| 5 | Merck and Co Inc | 1,234 | 5.2% |
| 6 | Novartis Ag | 1,234 | 5.2% |
| 7 | Abbott Laboratories | 1,234 | 5.2% |
| 8 | Novo Nordisk A | 1,234 | 5.2% |
| 9 | Pfizer Inc | 1,234 | 5.2% |
| 10 | Astrazeneca Plc | 1,234 | 5.2% |
| 0 | Sage Therapeutics Inc | 543 | 0.00 % |
Market cap and industry share for the rest of Sage Therapeutics Inc's industry peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2025-07-30.
Sage Therapeutics Inc's Profitability & Cost Structure
Trailing 12-month margins from SEC-filed financials. Operating margin is compared to the Major Pharmaceutical Preparations industry median; gross margin, EBITDA margin and capital intensity are compared to the live industry average (444 companies). See the full Major Pharmaceutical Preparations industry profitability benchmarks.| Metric | Company | Industry | Difference |
|---|---|---|---|
| Gross Margin | 0.00 % | 37.99 % (avg) | -38.0 pp |
| Operating Margin | - | industry median | - |
| EBITDA Margin | - | -6.20 % (avg) | - |
| Capital Intensity (Capex / Revenue) | 0.00 % | 7.59 % (avg) | -7.6 pp |
Source: CSIMarket API, trailing 12 months. SG&A and R&D as a share of revenue have limited coverage as this data is backfilled and appear only where reported. Higher capital intensity is not inherently negative; it reflects the industry's asset requirements.
Sage Therapeutics Inc's Valuation vs Competitive Position
Valuation multiples vs the Major Pharmaceutical Preparations industry average (444 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns. See the full Major Pharmaceutical Preparations industry valuation benchmarks.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 26.6x | - |
| EV / EBITDA | - | 15.9x | - |
| P/B | 1.0x | 4.3x | -3.2x |
| Return on Equity | -67.10 % | industry aggregate | -85.94 % |
| Return on Invested Capital | -35.78 % | -9.82 % (avg) | -25.96 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
Sage Therapeutics Inc's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in company reports.| Metric | 2016 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 |
|---|---|---|---|---|---|---|---|---|
| Revenue Growth | - | - | - | 500.00 % | -99.43 % | 21.85 % | 500.00 % | -52.30 % |
| Operating Margin | - | - | -10,310.48 % | 53.51 % | -7,306.74 % | - | - | - |
| Return on Invested Capital | -24.13 % | -19.68 % | -30.71 % | 27.33 % | -12.25 % | -18.96 % | -31.04 % | -36.62 % |
| P/E | - | - | - | 7.9x | - | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
Sage Therapeutics Inc's Competitive Forces (Porter's Five Forces)
Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.| Force | Assessment | Basis |
|---|---|---|
| Competitive Rivalry | High | Industry HHI of 875 (see Industry Market Structure & Concentration above) |
| Barriers to Entry | Lower than typical for the industry | Capital intensity (capex / revenue) of 0.00 % vs industry average 7.59 % (see Profitability & Cost Structure above) |
Note: see Methodology: Porter's Five Forces. Supplier power and buyer power are covered on Sage Therapeutics Inc's dedicated Suppliers and Customers pages, not here.
Sage Therapeutics Inc's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
- Latest-quarter revenue run-rate is accelerating (+79.9% annualized vs trailing 12 months).
Weaknesses
- Return on equity 85.9 points below the industry aggregate.
- Underperforming the U.S.A. 500 over the trailing 12 months.
- Piotroski F-Score of 2 or below, the standard financial-distress signal.
Opportunities
- A meaningful share of competitors (51.00 %) show financial-distress signals, a possible opening to gain share.
Threats
- Tracked peer group's revenue run-rate is broadly decelerating (-12.7% annualized).
Methodology: see Methodology: SWOT Analysis.
Sage Therapeutics Inc's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| Sage Therapeutics Inc | 1.30 | 8.83 | - |
| Eli Lilly And Company | 0.16 | 1.44 | 1.44 |
| Abbvie Inc | 0.19 | 0.79 | - |
| Amgen Inc | 0.46 | 1.26 | 5.86 |
| Vertex Pharmaceuticals Inc | 1.30 | 2.83 | 0.06 |
| Teva Pharmaceutical Industries Limited | 0.26 | 0.96 | 2.09 |
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Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
Sage Therapeutics Inc's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| Sage Therapeutics Inc | Q2 2025 | +265.8 % | - |
| Eli Lilly And Company | Q3 2026 | +38.6 % | +15.6 % |
| Abbvie Inc | Q3 2026 | +10.3 % | +2,143.6 % |
| Amgen Inc | Q2 2026 | +9.5 % | +65.9 % |
| Vertex Pharmaceuticals Inc | Q3 2026 | +11.8 % | -39.6 % |
| Teva Pharmaceutical Industries Limited | Q3 2026 | -1.9 % | -46.3 % |
| PEERS TOTAL | +19.6 % | +58.1 % |
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Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
Sage Therapeutics Inc's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| Sage Therapeutics Inc | Q2 2025 | - | - |
| Eli Lilly And Company | Q3 2026 | +30.7 % | +52.2 % |
| Abbvie Inc | Q3 2026 | -19.2 % | -21.0 % |
| Amgen Inc | Q2 2026 | -6.6 % | +39.0 % |
| Vertex Pharmaceuticals Inc | Q3 2026 | +26.8 % | -4.4 % |
| Teva Pharmaceutical Industries Limited | Q3 2026 | -10.2 % | +200.0 % |
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Sage Therapeutics Inc's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| Sage Therapeutics Inc | - | - | - |
| Eli Lilly And Company | 21.24% | 32.00% | 83.65% |
| Abbvie Inc | 7.48% | 12.87% | - |
| Amgen Inc | 9.48% | 13.08% | 89.32% |
| Vertex Pharmaceuticals Inc | 14.16% | 16.63% | 20.08% |
| Teva Pharmaceutical Industries Limited | 1.26% | 1.96% | 6.37% |
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ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
Sage Therapeutics Inc's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| Sage Therapeutics Inc | - | 7.72 |
| Eli Lilly And Company | 43.96 | 13.99 |
| Abbvie Inc | 50.14 | 7.82 |
| Amgen Inc | 28.60 | 6.57 |
| Vertex Pharmaceuticals Inc | 35.27 | 10.78 |
| Teva Pharmaceutical Industries Limited | 57.07 | 3.60 |
| PEERS AVERAGE | 53.86 | 8.73 |
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P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.