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Nextcure Inc's Competitiveness

A competitive positioning analysis and financial ratio benchmarking of Nextcure Inc (NXTC) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.

Peer Data As of Q2 2026
Competitors Tracked
140
Publicly traded peers
Peer Group Market Share
-
Share of combined sales, Q2 2026
Revenue Growth Y/Y
-
Peers: 11.55 %
Net Margin
-
Peers: 19.46 %

Key Findings: Nextcure Inc vs Its Competitors

  • Scale: Nextcure Inc ranks #367 of 544 companies by market capitalization in the Major Pharmaceutical Preparations industry, holding 0.0% of industry market cap.

Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).

API endpoints for this dataset
https://api.csimarket.com/api/v1/companies/NXTC/competitors
https://api.csimarket.com/api/v1/companies/NXTC/relationships
https://api.csimarket.com/api/v1/companies/NXTC/similar
Programmatic access for models, analytics, and integration workflows.

Nextcure Inc's Competitor Quality Breadth

Share of each group, trailing 12 months: profitable (net margin > 0), expanding (revenue growth > 0), growing faster than the industry's own median, and financially distressed (Piotroski F-Score of 2 or below).

Entity Profitable Expanding Above Industry Growth Distressed
Nextcure Inc - - - Yes
Competitors combined (139) 30% 74% 57% 45%
High-Confidence Competitors (13) 92% 75% 42% 31%
Similar-Size Competitors (10) 20% 40% 40% 56%

Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.

NXTC Stock Performance relative to its Competitors

NXTC Competitors (weighted) Percent change over the selected range

Nextcure Inc's Share Price Performance vs Peer Groups

Trailing 12-month total share price return, and the share of each group that outperformed the U.S.A. 500 over the same period. Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC.
48.1%beat U.S.A. 500
Competitors Combined
(63 of 131)
75%beat U.S.A. 500
High-Confidence
(9 of 12)
20%beat U.S.A. 500
Similar-Size
(2 of 10)
Entity TTM Share Price Return
(group: median)
vs U.S.A. 500
Nextcure Inc -12.80 % Underperformed
Competitors combined (131) 40.4% 63.2%
High-Confidence Competitors (12) 40.4% 63.2%
Similar-Size Competitors (10) 40.4% 63.2%
Similar Growth & Profitability (0) 40.4% 63.2%
Peer Group Share Price Returns

TTM share price return and U.S.A. 500 outperformance for Nextcure Inc's competitor groups requires a Commercial License.

Source: CSIMarket API (daily market-structure computation). Outperformance is trailing-12-month total return vs the U.S.A. 500 over the same window, not risk-adjusted.

NXTC Stock Performance relative to High-Confidence Competitors

NXTC High-Confidence Competitors (equal-weighted, 16) Percent change over the selected range

NXTC Stock Performance relative to Similar-Size Competitors

NXTC Similar-Size Competitors (equal-weighted, 10) Percent change over the selected range

5 Best-Performing Tracked Competitors, Trailing 12 Months

#CompetitorTTM Share Price Returnvs U.S.A. 500
1 Gt Biopharma Inc 282.9% Outperformed
2 Adlai Nortye Ltd 282.9% Outperformed
3 Erasca Inc 282.9% Outperformed
4 Sellas Life Sciences Group Inc 282.9% Outperformed
5 Spruce Biosciences Inc 282.9% Outperformed
Best-Performing Competitor Returns

TTM share price return and U.S.A. 500 outperformance for Nextcure Inc's best-performing tracked competitors requires a Commercial License.

Source: CSIMarket API, trailing 12 months.

Nextcure Inc's Comment on Competition and Industry Peers

The company operates in a competitive environment that includes larger biopharmaceutical, biotechnology, and therapeutics firms, as well as smaller or early-stage companies, universities, and research institutions developing cancer therapeutics. In the CDH6-targeted program space, SIM0505 competes with raludotatug deruxtecan (R-DXd), co-developed by Merck & Co. and Daiichi Sankyo, OnCusp Therapeutics' CUSP06, and Hansoh Pharma’s HS-20124. In the ovarian cancer sector, competitors include AbbVie’s marketed product Elahere, Genmab’s clinical candidate rinatabart sesutecan (Rina-S), and the clinical candidate TUB-040 targeting NaPi2b. The company's competitive position relies on differentiating SIM0505 through its proprietary topoisomerase 1 inhibitor payload, safety profile, and efficacy across tumor types.

Publicly Traded Peers of Nextcure Inc

Revenue and income for trailing 12 months, in millions of $, except employees
Company Market Cap Revenues Income Employees
Nextcure Inc 26.97 - -42.75 40
Astrazeneca Plc 259,526.30 58,739.00 10,233.00 83,100
Vertex Pharmaceuticals Inc 134,661.38 12,587.20 4,405.20 405
Bristol myers Squibb Company 130,826.24 49,186.00 9,274.00 32,500
Regeneron Pharmaceuticals Inc 79,738.50 15,534.70 4,328.70 15,410
Zai Lab Limited 28,695.05 449.61 -188.21 1,784
SUBTOTAL 872,931.54 158,268.37 24,026.40 164,700
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Sources: Nextcure Inc's official press releases and regulatory filings; CSIMarket.com's market research; and the financial filings and press releases of the other companies cited.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Nextcure Inc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.

Nextcure Inc's Competitors Named by the Company

Competitive relationships identified from SEC filings and corroborating sources, each with a basis and confidence.
Competitor Basis Confidence Active Sources
Amgen Named by the company 85% 2022 to 2026 3
Daiichi Sankyo Named by the company 85% 2022 to 2026 3
Hansoh Pharma Named by the company 85% 2022 to 2026 3
Pfizer Inc. Named by the company 85% 2022 to 2026 3
BMS Named by the company 85% 2022 to 2026 3
Genmab Named by the company 85% 2022 to 2026 3
Novartis AG Named by the company 85% 2022 to 2026 3
Astra Zeneca plc Named by the company 85% 2022 to 2026 3
DualityBio Named by the company 85% 2022 to 2026 3
Merck & Co. Named by the company 85% 2022 to 2026 3
Sanofi S.A. Named by the company 85% 2022 to 2026 3
AbbVie Named by the company 85% 2022 to 2026 3
Bristol-Myers Squibb Company Named by the company 85% 2022 to 2026 3
GlaxoSmithKline PLC Named by the company 85% 2022 to 2026 3
OnCusp Therapeutics Named by the company 85% 2022 to 2026 3
BeiGene Ltd. Named by the company 85% 2022 to 2026 3
Genentech, Inc. Named by the company 85% 2022 to 2026 3
Mersana Named by the company 85% 2022 to 2026 3
Pyxis Oncology Inc Named by the company 85% 2022 to 2026 3
Carisma Therapeutics Inc Named by the company 85% 2022 to 2026 3
Ngm Biopharmaceuticals Inc Named by the company 85% 2022 to 2026 3
Competitor Evidence Detail

Filing basis, confidence, active dates and source counts for Nextcure Inc's named competitors require a Commercial License.

Methodology: relationships are extracted from SEC filings (named-competitor disclosures) and corroborating sources. Named by the company = explicitly disclosed as a competitor; Inferred = derived from corroborating signals. Confidence reflects evidence strength.

Nextcure Inc's Business Segment Mix vs Peers

Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).
Company Largest Segment 2nd Segment 3rd Segment
Vertex Pharmaceuticals Inc Pharmaceuticals 100.00 % - -
Incyte Corporation Reportable 100.00 % - -
Madrigal Pharmaceuticals Inc Reportable 100.00 % - -
Allegion Plc Allegion Americas 79.77 % Allegion International 20.23 % -
Hutchmed china Limited Other Ventures segment 47.94 % Marketed Products Subsegment 39.08 % Research and Development Subsegment 12.98 %

Source: operating segment revenue as reported in each company's SEC filings (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).

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Nextcure Inc's Productivity vs Peers Comparison

Revenue and income per employee, trailing 12 months, in $; market cap in millions of $
CompanyMarket CapRevenue / EmployeeIncome / Employee
Nextcure Inc 27 - -1,068,700
Astrazeneca Plc 259,526 706,847 123,141
Vertex Pharmaceuticals Inc 134,661 31,079,506 10,877,037
Bristol myers Squibb Company 130,826 1,513,415 285,354
Regeneron Pharmaceuticals Inc 79,739 1,008,092 280,902
Zai Lab Limited 28,695 252,026 -105,501
PEERS TOTAL 872,905 961,183 146,175
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Nextcure Inc's Geographic Revenue Exposure vs Peers

Revenue by country/region as reported in each company's most recent filing. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.
Company Largest Market 2nd Market 3rd Market
Vertex Pharmaceuticals Inc United States 61.68 % Europe 29.33 % Other Countries Outside of the United States and Europe 8.99 %
Bristol myers Squibb Company United States 67.79 % Non-US 29.98 % Other Region 2.24 %
Incyte Corporation United States 93.16 % Europe 6.48 % Other Countries 0.36 %
United Therapeutics Corporation UNITED STATES 95.23 % Non-US 4.77 % -
Hutchmed china Limited CN 74.28 % United States and Others 25.72 % -

Source: revenue geography as reported in each company's SEC filings (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.

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Nextcure Inc's Position in Industry Market Structure

Market-capitalization share and concentration across all 498 companies in Nextcure Inc's industry classification, broader than the peer set above. Market cap in millions of $.

Nextcure Inc ranks #367 of 498 companies by market capitalization in its industry, holding 0.00 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 823, indicating a unconcentrated market structure (U.S. antitrust guidance: below 1,500 unconcentrated, 1,500 to 2,500 moderately concentrated, above 2,500 highly concentrated).

Rank Company Market Cap Industry Share
1 Eli Lilly And Company 1,058,838 19.26 %
2 Johnson and Johnson 663,585 12.07 %
3 Beone Medicines Ltd 552,468 10.05 %
4 Abbvie Inc 471,582 8.58 %
5 Merck and Co Inc 1,234 5.2%
6 Novartis Ag 1,234 5.2%
7 Abbott Laboratories 1,234 5.2%
8 Novo Nordisk A 1,234 5.2%
9 Pfizer Inc 1,234 5.2%
10 Vertex Pharmaceuticals Inc 1,234 5.2%
367 Nextcure Inc 27 0.00 %
Full Industry Market Structure

Market cap and industry share for the rest of Nextcure Inc's industry peers requires a Commercial License.

Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2026-09-28.

Nextcure Inc's Same-Size Peers & Stock Performance

Peers chosen by closeness in market-cap rank within the same industry classification (not the named-competitor list above). Trailing 12-month total return, 3-month price momentum, beta and Sharpe ratio vs the broad U.S. market.
Rank Company Market Cap TTM Return 3M Momentum Beta Sharpe (1Y)
362 Calcimedica Inc 29 -41.86 % 81.35 % 0.10 0.50
363 Kyntra Bio Inc 28 -44.06 % -10.22 % 1.56 -0.93
364 Igc Pharma Inc 27 -24.62 % 5.00 % 0.60 -0.43
365 Abvc Biopharma Inc 27 -64.78 % -38.95 % 0.84 -1.06
366 Palatin Technologies Inc 1,234 12.3% 4.5% 1.10 0.80
367 Nextcure Inc 27 -12.80 % 168.09 % 0.81 0.68
368 Aytu Biopharma Inc 1,234 12.3% 4.5% 1.10 0.80
369 Bioharvest Sciences Inc 1,234 12.3% 4.5% 1.10 0.80
370 Therapeuticsmd Inc 1,234 12.3% 4.5% 1.10 0.80
371 Provectus Biopharmaceuticals Inc 1,234 12.3% 4.5% 1.10 0.80
372 Cellectar Biosciences Inc 1,234 12.3% 4.5% 1.10 0.80
Full Same-Size Peer Performance

Market cap, return, momentum, beta and Sharpe ratio for the rest of Nextcure Inc's same-size peers requires a Commercial License.

Source: CSIMarket API (daily market-structure computation); returns and risk metrics as of 2026-09-28. Beta and Sharpe ratio are versus the broad U.S. equity market, not this industry.

Nextcure Inc's Valuation vs Competitive Position

Valuation multiples vs the Major Pharmaceutical Preparations industry average (341 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns.
Metric Company Industry Average Difference
P/E - 25.1x -
EV / EBITDA - 17.3x -
P/B 1.1x 4.5x -3.4x
Return on Equity -175.46 % industry aggregate -192.71 %
Return on Invested Capital -82.45 % -2.95 % (avg) -79.50 %

Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.

Nextcure Inc's Multi-Year Financial Trajectory

Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in SEC filings.
Metric 2019202020212022202320242025
Revenue Growth -------
Operating Margin -------
Return on Invested Capital --6.54 %-13.74 %-19.75 %-24.70 %-35.36 %-74.19 %
P/E -------

Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.

Nextcure Inc's BCG Growth-Share Matrix

Relative market share (vs Nextcure Inc's largest competitor by market cap) against industry revenue growth, using the standard textbook thresholds (1.0x share, 10% growth) a common framework, not a precision instrument.

Question Mark Star Dog Cash Cow Relative Market Share (vs largest competitor) Industry Revenue Growth (%) Nextcure Inc

Nextcure Inc falls in the Dog quadrant: relative market share of 0.00x vs its largest competitor, in an industry growing revenue 8.0% (median, trailing 12 months).

Source: CSIMarket API (market-cap share and industry revenue growth). The 10% growth and 1.0x share lines are standard textbook thresholds, not derived from this industry's own distribution.

Nextcure Inc's Competitive Forces (Porter's Five Forces)

Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.
Force Assessment Basis
Competitive Rivalry High Industry HHI of 823 (see Industry Market Structure & Concentration above)
Supplier Power Not covered on this page See Nextcure Inc's dedicated suppliers page for concentration and dependency data
Buyer Power Not covered on this page See Nextcure Inc's dedicated customers page for concentration and dependency data
Threat of Substitutes - No systematic data source for cross-product substitution exists in this system; not estimated

Note: this is a partial, data-grounded application of the framework, not a complete strategic assessment. Rivalry and barriers-to-entry readings are mechanical translations of the HHI and capital-intensity figures shown elsewhere on this page, not independent judgments.

Nextcure Inc's Industry Attractiveness & Competitive Strength

A CSIMarket composite, not a standard field: each axis is an equal-weighted average of three factors already shown elsewhere on this page (industry growth, industry profitability and rivalry for attractiveness; relative market share, profitability and growth vs industry for strength). Disclosed as a designed methodology, not a precision measurement.

High Strength
Medium Strength
Low Strength
High Attractiveness
Invest / Grow
Invest / Grow
Selective
Medium Attractiveness
Invest / Grow
Selective
Harvest
Low Attractiveness
Selective
Harvest
Harvest / Divest Nextcure Inc

Nextcure Inc falls in the Low attractiveness / Low strength cell: Harvest / Divest.

Source: CSIMarket API, trailing 12 months. Each axis score is a simple 1(low)/2(medium)/3(high) average across its three inputs -- a transparent, disclosed simplification, not a validated academic scoring model.

Nextcure Inc's SWOT

Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.

Strengths

No rule matched.

Weaknesses

  • Return on equity 192.7 points below the industry aggregate.
  • Underperforming the U.S.A. 500 over the trailing 12 months.
  • Low relative market share vs the industry leader (0.00x).
  • Piotroski F-Score of 2 or below, the standard financial-distress signal.

Opportunities

  • A meaningful share of tracked competitors (44.50 %) show financial-distress signals, a possible opening to gain share.

Threats

No rule matched.

Methodology: mechanical, rule-based SWOT. Each bullet reuses a figure already sourced and cited elsewhere on this page; nothing here is generated narrative or independent analyst judgment.

Nextcure Inc's Financial Strength vs Peers Comparison

Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months
CompanyQuick RatioWorking CapitalDebt / EquityAsset Turnover
Nextcure Inc 1.83 3.74 - -
Astrazeneca Plc 0.19 0.94 0.51 0.51
Vertex Pharmaceuticals Inc 1.34 2.85 - 0.48
Bristol myers Squibb Company 0.49 1.35 2.31 0.54
Regeneron Pharmaceuticals Inc 0.57 3.74 0.06 0.38
Zai Lab Limited 1.66 2.45 0.31 0.40
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Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.

Nextcure Inc's Revenue and Income Growth vs Peers

Quarterly revenue and net income growth, year over year and quarter over quarter
CompanyPeriodRevenue Y/YRevenue Q/QIncome Y/YIncome Q/Q
Nextcure Inc Q2 2026----
Astrazeneca PlcQ4 2025+8.6 %+8.6 %+45.3 %+45.3 %
Vertex Pharmaceuticals IncQ2 2026+12.5 %+11.6 %+6.5 %+6.6 %
Bristol myers Squibb CompanyQ2 2026+5.7 %+12.9 %+152.6 %+23.8 %
Regeneron Pharmaceuticals Inc Q2 2026+16.7 %+19.0 %-6.8 %+78.3 %
Zai Lab LimitedQ2 2026-3.3 %+6.7 %--
PEERS TOTAL+9.7 %+9.7 %+85.8 %+87.5 %
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Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.

Nextcure Inc's Peers' Costs of Sales and Capital Expenditures

Context for revenue growth: peer costs and capex, year over year and quarter over quarter
CompanyPeriodCosts Y/YCosts Q/QCapex Y/YCapex Q/Q
Nextcure Inc Q2 2026----
Astrazeneca PlcQ4 2025+11.2 %+11.2 %+46.0 %+46.0 %
Vertex Pharmaceuticals IncQ2 2026+20.0 %+24.5 %-23.0 %-15.9 %
Bristol myers Squibb CompanyQ2 2026+10.5 %+8.9 %-15.5 %-12.1 %
Regeneron Pharmaceuticals Inc Q2 2026+109.2 %+54.4 %+9.7 %+4.2 %
Zai Lab LimitedQ2 2026+12.0 %+25.7 %-53.5 %-87.4 %
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Nextcure Inc's Returns and Turnover vs Peers

ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover
CompanyROAROIROEReceivables TurnoverInventory Turnover
Nextcure Inc -----
Astrazeneca Plc8.97%19.67%21.00%3.87-
Vertex Pharmaceuticals Inc16.88%19.97%23.31%6.191.03
Bristol myers Squibb Company10.27%13.58%46.65%4.605.37
Regeneron Pharmaceuticals Inc 10.60%11.83%13.81%2.620.49
Zai Lab Limited---5.713.39
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ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).

Nextcure Inc's Valuation vs Peers

P/E, price to sales, PEG, price to cash flow and price to book
CompanyP/EPrice / SalesPEGP/CFPrice / Book
Nextcure Inc ---2.602.22
Astrazeneca Plc25.384.420.3542.095.33
Vertex Pharmaceuticals Inc30.7710.70-114.896.65
Bristol myers Squibb Company14.062.660.20-5.86
Regeneron Pharmaceuticals Inc 18.635.136.14177.042.51
Zai Lab Limited-63.82--47.27
PEERS AVERAGE36.335.52100.705.31
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P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.