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Aptose Biosciences Inc's Competitiveness

A competitive positioning analysis and financial ratio benchmarking of Aptose Biosciences Inc (APTO) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.

Peer Data As of Q1 2026
Competitors
11
Named by the company
Peer Group Market Share
-
Share of combined sales, Q1 2026
Revenue Growth Y/Y
-
Peers: 8.20 %
Net Margin
-
Peers: 19.56 %

API endpoints for this dataset

https://api.csimarket.com/api/v1/companies/APTO/competitors
https://api.csimarket.com/api/v1/companies/APTO/relationships
https://api.csimarket.com/api/v1/companies/APTO/similar
Programmatic access for models, analytics, and integration workflows.
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Aptose Biosciences Inc's Competitor Quality Breadth

Group definitions: see Methodology: Performance Group Definitions.

Entity Profitable Expanding Above Industry Growth Distressed
Aptose Biosciences Inc - - - Yes
Competitors combined (19) 71% 89% 56% 50%
High-Confidence Competitors (8) 100% 100% 71% 13%

Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.

APTO Stock Performance relative to its Competitors

APTO Competitors (weighted) Percent change over the selected range

Aptose Biosciences Inc's Share Price Performance vs Peer Groups

Trailing 12-month total share price return, and the share of each group that outperformed the U.S.A. 500 over the same period. Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC.
57.9%beat U.S.A. 500
Competitors Combined
(11 of 19)
75%beat U.S.A. 500
High-Confidence
(6 of 8)
Entity TTM Share Price Return
(group: median)
vs U.S.A. 500
Aptose Biosciences Inc -96.20 % Underperformed
Competitors combined (19) 40.4% 63.2%
High-Confidence Competitors (8) 40.4% 63.2%
Similar-Size Competitors (0) 40.4% 63.2%
Similar Growth & Profitability (0) 40.4% 63.2%
Peer Group Share Price Returns

TTM share price return and U.S.A. 500 outperformance for Aptose Biosciences Inc's competitor groups requires a Commercial License.

Source: CSIMarket API (daily market-structure computation). Outperformance is trailing-12-month total return vs the U.S.A. 500 over the same window, not risk-adjusted.

APTO Stock Performance relative to High-Confidence Competitors

APTO High-Confidence Competitors (equal-weighted, 8) Percent change over the selected range

5 Best-Performing Tracked Competitors, Trailing 12 Months

#CompetitorTTM Share Price Returnvs U.S.A. 500
1 Relay Therapeutics Inc 282.9% Outperformed
2 Iovance Biotherapeutics inc 282.9% Outperformed
3 Revolution Medicines Inc 282.9% Outperformed
4 Agenus Inc 282.9% Outperformed
5 Scholar Rock Holding Corp 282.9% Outperformed
Best-Performing Competitor Returns

TTM share price return and U.S.A. 500 outperformance for Aptose Biosciences Inc's best-performing competitors requires a Commercial License.

Source: CSIMarket API, trailing 12 months.

Aptose Biosciences Inc's Comment on Competition and Industry Peers

Aptose operates in the highly competitive biotechnology and pharmaceutical industries, where numerous companies engage in similar activities. Competitors include established pharmaceutical companies with greater financial, technical, research and development, marketing, distribution, production, and human resources capabilities than Aptose. Competition also comes from companies seeking partnerships with biotechnology and pharmaceutical firms and academic institutions. Competitive drugs may target different aspects of cancer but can be used in combination therapies with Aptose's drugs. Key factors influencing competitiveness include the stage of development, timing of commercialization, patent protection, safety profiles, and cost-benefit profiles. In November 2021, Aptose licensed exclusive worldwide rights to tuspetinib from Hanmi and holds patents covering tuspetinib and its analogs, providing a strong intellectual property position.

Publicly Traded Peers of Aptose Biosciences Inc

Revenue and income for trailing 12 months, in millions of $, except employees
Company Market Cap Revenues Income Employees
Aptose Biosciences Inc 4.36 - -27.56 14
Astrazeneca Plc 288,001.56 58,739.00 10,233.00 83,100
Amgen Inc 255,014.76 38,903.00 9,391.00 13,000
Gilead Sciences Inc 210,105.45 30,988.00 -3,863.00 17,000
Beone Medicines Ltd 47,513.48 6,606.28 915.57 12,000
Revolution Medicines Inc 37,191.09 29.51 -1,768.28 883
SUBTOTAL 880,170.89 142,557.31 13,697.82 130,920
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Sources: see Methodology: Peer & Competitor Identification, Sourcing.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Aptose Biosciences Inc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.

Aptose Biosciences Inc's Competitors Named by the Company

Competitive relationships identified from Aptose Biosciences Inc reports and corroborating sources, each with a basis and confidence.
Competitor Basis Confidence Active Sources
Hanmi Company report 85% 2022 to 2026 3
Curis Inc Company report 85% 2022 to 2026 3
Servier Company report 85% 2022 to 2026 3
Pfizer Company report 85% 2022 to 2026 3
AbbVie Company report 85% 2022 to 2026 3
Jazz Company report 85% 2022 to 2026 3
Rigel Company report 85% 2022 to 2026 3
Astellas Company report 85% 2022 to 2026 3
Novartis Company report 85% 2022 to 2026 3
AstraZeneca Company report 85% 2022 to 2026 3
Beigene Co., Ltd. Company report 85% 2022 to 2026 3
Competitor Evidence Detail

Company report basis, confidence, active dates and source counts for Aptose Biosciences Inc's named competitors require a Commercial License.

Methodology: see Methodology: Peer & Competitor Identification, Sourcing.

Aptose Biosciences Inc's Business Segment Mix vs Peers

Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).
Company Largest Segment 2nd Segment 3rd Segment
Amgen Inc Reportable 100.00 % - -
Incyte Corporation Reportable 100.00 % - -
Scholar Rock Holding Corp Single Reportable Segment 100.00 % - -
Iovance Biotherapeutics inc Single reportable segment 100.00 % - -

Source: operating segment revenue as reported in each company's reports (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).

Aptose Biosciences Inc's Productivity vs Peers Comparison

Revenue and income per employee, trailing 12 months, in $; market cap in millions of $
CompanyMarket CapRevenue / EmployeeIncome / Employee
Aptose Biosciences Inc 4 - -1,968,500
Astrazeneca Plc 288,002 706,847 123,141
Amgen Inc 255,015 2,992,538 722,385
Gilead Sciences Inc 210,105 1,822,824 -227,235
Beone Medicines Ltd 47,513 550,523 76,298
Revolution Medicines Inc 37,191 33,420 -2,002,588
PEERS TOTAL 880,167 1,089,005 104,849
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Aptose Biosciences Inc's Geographic Revenue Exposure vs Peers

Revenue by country/region as reported in each company's most recent report. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.
Company Largest Market 2nd Market 3rd Market
Gilead Sciences Inc United States 76.66 % Europe 12.83 % Rest of World 10.51 %
Beone Medicines Ltd United States 54.39 % China 28.38 % Europe 12.68 %
Incyte Corporation United States 92.15 % Europe 6.90 % Other Countries 0.95 %
Iovance Biotherapeutics inc US 98.66 % Non Us 1.34 % -
Agenus Inc US 100.00 % - -

Source: revenue geography as reported in each company's reports (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.

Aptose Biosciences Inc's Position in Industry Market Structure

Market-capitalization share and concentration across all 157 companies in Aptose Biosciences Inc's industry classification, broader than the peer set above. Market cap in millions of $.

Aptose Biosciences Inc ranks #0 of 157 companies by market capitalization in its industry, holding 0.00 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 1,443, indicating a unconcentrated market structure (see Methodology: Market Structure & Concentration).

Rank Company Market Cap Industry Share
1 Amgen Inc 254,081 27.22 %
2 Gilead Sciences Inc 208,762 22.37 %
3 Moderna Inc 92,077 9.86 %
4 Argenx Se 64,796 6.94 %
5 Biogen Inc 1,234 5.2%
6 Revolution Medicines Inc 1,234 5.2%
7 Biontech Se 1,234 5.2%
8 Exelixis Inc 1,234 5.2%
9 Neurocrine Biosciences Inc 1,234 5.2%
10 Kymera Therapeutics Inc 1,234 5.2%
0 Aptose Biosciences Inc 4 0.00 %
Full Industry Market Structure

Market cap and industry share for the rest of Aptose Biosciences Inc's industry peers requires a Commercial License.

Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2025-04-01.

Aptose Biosciences Inc's Multi-Year Financial Trajectory

Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in company reports.
Metric 2019202020212022202320242025
Revenue Growth -------
Operating Margin -------
Return on Invested Capital -31.07 %-26.81 %-35.28 %-41.39 %-226.69 %--
P/E -------

Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.

Aptose Biosciences Inc's Competitive Forces (Porter's Five Forces)

Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.
Force Assessment Basis
Competitive Rivalry High Industry HHI of 1,443 (see Industry Market Structure & Concentration above)

Note: see Methodology: Porter's Five Forces. Supplier power and buyer power are covered on Aptose Biosciences Inc's dedicated Suppliers and Customers pages, not here.

Aptose Biosciences Inc's SWOT

Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.

Strengths

No rule matched.

Weaknesses

  • Underperforming the U.S.A. 500 over the trailing 12 months.
  • Piotroski F-Score of 2 or below, the standard financial-distress signal.

Opportunities

  • A meaningful share of competitors (50.00 %) show financial-distress signals, a possible opening to gain share.

Threats

  • Tracked peer group's revenue run-rate is broadly decelerating (-11.1% annualized).

Methodology: see Methodology: SWOT Analysis.

Aptose Biosciences Inc's Financial Strength vs Peers Comparison

Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months
CompanyQuick RatioWorking CapitalDebt / EquityAsset Turnover
Aptose Biosciences Inc 0.20 0.54 - -
Astrazeneca Plc 0.19 0.94 0.51 0.51
Amgen Inc 0.49 1.31 5.27 0.42
Gilead Sciences Inc - 1.52 1.47 0.57
Beone Medicines Ltd 2.58 3.50 0.21 0.74
Revolution Medicines Inc 1.35 7.28 0.07 0.01
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Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.

Aptose Biosciences Inc's Revenue and Income Growth vs Peers

Quarterly revenue and net income growth, year over year and quarter over quarter
CompanyPeriodRevenue Y/YRevenue Q/QIncome Y/YIncome Q/Q
Aptose Biosciences Inc Q1 2026----
Astrazeneca PlcQ4 2025+8.6 %+8.6 %+45.3 %+45.3 %
Amgen Inc Q3 2026+8.5 %+3.1 %+20.1 %+62.7 %
Gilead Sciences Inc Q3 2026+6.8 %+6.4 %-20.4 %-
Beone Medicines Ltd Q3 2026+33.9 %+10.8 %+208.2 %+62.3 %
Revolution Medicines Inc Q2 2026----
PEERS TOTAL+9.0 %+7.3 %+14.6 %-
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Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.

Aptose Biosciences Inc's Peers' Costs of Sales and Capital Expenditures

Context for revenue growth: peer costs and capex, year over year and quarter over quarter
CompanyPeriodCosts Y/YCosts Q/QCapex Y/YCapex Q/Q
Aptose Biosciences Inc Q1 2026----
Astrazeneca PlcQ4 2025+11.2 %+11.2 %+46.0 %+46.0 %
Amgen Inc Q3 2026-9.5 %-0.8 %+34.6 %+14.4 %
Gilead Sciences Inc Q3 2026+0.1 %-0.5 %+61.2 %+69.3 %
Beone Medicines Ltd Q3 2026+10.7 %+24.3 %-26.8 %+28.0 %
Revolution Medicines Inc Q2 2026---69.3 %+48.6 %
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Aptose Biosciences Inc's Returns and Turnover vs Peers

ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover
CompanyROAROIROEReceivables TurnoverInventory Turnover
Aptose Biosciences Inc -----
Astrazeneca Plc8.97%19.67%21.00%3.87-
Amgen Inc 10.02%13.64%85.59%3.961.81
Gilead Sciences Inc ---6.293.30
Beone Medicines Ltd 10.23%13.17%18.21%6.690.99
Revolution Medicines Inc -----
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ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).

Aptose Biosciences Inc's Valuation vs Peers

P/E, price to sales, PEG, price to cash flow and price to book
CompanyP/EPrice / SalesPEGP/CFPrice / Book
Aptose Biosciences Inc -----
Astrazeneca Plc28.194.900.3946.715.91
Amgen Inc 27.086.560.4768.0917.77
Gilead Sciences Inc -6.78--16.11
Beone Medicines Ltd 53.297.19-27.068.16
Revolution Medicines Inc -1,260.29-89.8514.27
PEERS AVERAGE64.266.1774.369.45
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P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.

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