Personalis Inc's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of Personalis Inc (PSNL) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
Key Findings: Personalis Inc vs Its Competitors
- TTM: Trailing 12-month revenue of 70M vs 14,505M combined for tracked competitors (0.5% combined share).
- Trending: Latest-quarter revenue run-rate is accelerating (+28.4% annualized vs trailing 12 months), vs accelerating (+7.5%) for its tracked peer group.
- Growth: Personalis Inc generated 30.0% revenue growth year over year in Q2 2026, vs 17.2% for its tracked competitors combined.
- Profitability: Its -141.7% net margin compares with 2.7% for the peer group.
- Scale: Personalis Inc ranks #21 of 47 companies by market capitalization in the Medical Laboratories industry, holding 0.5% of industry market cap.
- Peer revenue share: Personalis Inc accounted for 0.6% of combined revenue among its tracked peer group, up from 0.5% a year earlier.
- Peer differentiation: Revenue per employee of $0.27M compares with $0.46M for the peer group (0.6x).
Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).
PSNL Sales vs. its Competitors, Q2 2026
Personalis Inc reported revenue growth of 29.96 % year on year in Q2 2026, above its competitors' combined revenue growth of 17.24 %.
With a net margin of -141.71 %, Personalis Inc reported lower profitability than its competitors (2.68 %).
Personalis Inc generated 0.57 % of the combined sales of its peer group, up from 0.51 % a year earlier.
Personalis Inc vs. its Competitors, Q2 2026
Revenue growth, year on year
Net margin
Revenue run-rate vs trailing 12 months
TTM net margin
TTM = trailing twelve months. Run-rate annualizes the latest quarter (×4) and compares it to TTM. In millions of $. High-Confidence Competitors are named as a competitor directly in an SEC filing; Similar-Size Competitors are the closest peers by market-cap rank within the same industry; Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC, all independent of the competitor list.
TTM revenue, latest-quarter run-rate and net income/margin benchmarked across Personalis Inc and its 4 competitor groupings. Available under Commercial License.
| Entity | TTM Revenue | Rev Run-rate vs TTM |
|---|---|---|
| Personalis Inc | $12,345M | +12.3% · Accelerating |
| Competitors combined | $12,345M | +12.3% · Accelerating |
| High-Confidence Competitors (11) | $12,345M | +12.3% · Accelerating |
| Similar-Size Competitors (9) | $12,345M | +12.3% · Accelerating |
| Similar Growth & Profitability (5) | $12,345M | +12.3% · Accelerating |
TTM revenue, run-rate and net margin benchmarking across Personalis Inc's competitor groups requires a Commercial License.
For context: the Medical Laboratories industry grew revenue 5.7% year over year, combined, vs 30.0% for Personalis Inc. Personalis Inc's share of combined industry revenue moved from 0.03% to 0.04%, a gain of 0.01 percentage points.
Personalis Inc's Competitor Quality Breadth
Share of each group, trailing 12 months: profitable (net margin > 0), expanding (revenue growth > 0), growing faster than the industry's own median, and financially distressed (Piotroski F-Score of 2 or below).
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| Personalis Inc | No | No | No | Yes |
| Competitors combined (17) | ||||
| High-Confidence Competitors (15) | ||||
| Similar-Size Competitors (10) | ||||
| Similar Growth & Profitability (8) | 0.00 % (0 of 8) | 25.00 % (2 of 8) | 25.00 % (2 of 8) | 50.00 % (4 of 8) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
PSNL Stock Performance relative to its Competitors
PSNL Stock Performance relative to High-Confidence Competitors
PSNL Stock Performance relative to Similar-Size Competitors
PSNL Stock Performance relative to Similar Growth & Profitability Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Caredx Inc | 282.9% | Outperformed |
| 2 | Biodesix Inc | 282.9% | Outperformed |
| 3 | Guardant Health Inc | 282.9% | Outperformed |
| 4 | Illumina Inc | 282.9% | Outperformed |
| 5 | Grail Inc | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for Personalis Inc's best-performing tracked competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Personalis Inc's Comment on Competition and Industry Peers
Publicly Traded Peers of Personalis Inc
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
| Personalis Inc | 1,720.53 | 69.67 |
| Natera Inc | 58,997.99 | 2,707.08 |
| Illumina Inc | 41,600.70 | 4,493.00 |
| Guardant Health Inc | 23,561.31 | 1,183.11 |
| Exact Sciences Corporation | 19,599.02 | 3,245.31 |
| Grail Inc | 5,718.02 | 165.26 |
| SUBTOTAL | 167,241.30 | 18,004.78 |
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Sources: Personalis Inc's official press releases and regulatory filings; CSIMarket.com's market research; and the financial filings and press releases of the other companies cited.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Personalis Inc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
Personalis Inc's Competitors Named by the Company
Competitive relationships identified from SEC filings and corroborating sources, each with a basis and confidence.| Competitor | Basis | Confidence |
|---|---|---|
| Veracyte Inc | Named by the company | 85% |
| Natera Inc | Named by the company | 85% |
| Invitae Corporation | Named by the company | 85% |
| NanoString Technologies, Inc. | Named by the company | 85% |
| Sema4 | Named by the company | 85% |
| Adaptive Biotechnologies Corporation | Named by the company | 85% |
| Foundation Medicine, Inc. | Named by the company | 85% |
| Illumina | Named by the company | 85% |
| ModernaTX, Inc. | Named by the company | 85% |
| Roche Holdings, Inc. | Named by the company | 85% |
| Grail Inc | Named by the company | 85% |
| C2i Genomics, Inc. | Named by the company | 85% |
| Genosity, Inc. | Named by the company | 85% |
| Laboratory Corporation of America Holdings | Named by the company | 85% |
| NeoGenomics | Named by the company | 85% |
| Tempus AI, Inc. | Named by the company | 85% |
| Biodesix Inc | Named by the company | 85% |
| Adela, Inc. | Named by the company | 85% |
| Freenome, Inc. | Named by the company | 85% |
| Inivata Limited | Named by the company | 85% |
| Mount Sinai Genomics, Inc. | Named by the company | 85% |
| Roche Molecular Systems, Inc. | Named by the company | 85% |
| Covance Inc. | Named by the company | 85% |
| Guardant Health, Inc. | Named by the company | 85% |
| Merck & Co., Inc. | Named by the company | 85% |
| Personal Genome Diagnostics, Inc. | Named by the company | 85% |
| Tempus, Inc. | Named by the company | 85% |
| Caris Life Sciences Inc | Named by the company | 85% |
| ArcherDx, Inc. | Named by the company | 85% |
| Geneseeq Technology Inc. | Named by the company | 85% |
Filing basis, confidence, active dates and source counts for Personalis Inc's named competitors require a Commercial License.
Methodology: relationships are extracted from SEC filings (named-competitor disclosures) and corroborating sources. Named by the company = explicitly disclosed as a competitor; Inferred = derived from corroborating signals. Confidence reflects evidence strength.
Personalis Inc's Business Segment Mix vs Peers
Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).| Company | Largest Segment |
|---|---|
| Natera Inc | Reportable 100.00 % |
| Illumina Inc | Sequencing 90.94 % |
| Guardant Health Inc | Reportable 100.00 % |
| Grail Inc | Reportable 100.00 % |
| Veracyte Inc | Reportable 100.00 % |
Source: operating segment revenue as reported in each company's SEC filings (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).
Personalis Inc's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| Personalis Inc | 1,721 | 267,958 | -412,227 |
| Natera Inc | 58,998 | 440,892 | -31,327 |
| Illumina Inc | 41,601 | 3,510,156 | 644,531 |
| Guardant Health Inc | 23,561 | 472,109 | -180,940 |
| Exact Sciences Corporation | 19,599 | 450,738 | -28,882 |
| Grail Inc | 5,718 | 181,608 | -430,315 |
| PEERS TOTAL | 165,521 | 462,639 | -8,369 |
Personalis Inc's Geographic Revenue Exposure vs Peers
Revenue by country/region as reported in each company's most recent filing. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.| Company | Largest Market |
|---|---|
| Natera Inc | United States 98.24 % |
| Illumina Inc | United States and Canada 56.34 % |
| Guardant Health Inc | United States 94.35 % |
| Exact Sciences Corporation | United States 93.11 % |
| Caredx Inc | United States 96.56 % |
Source: revenue geography as reported in each company's SEC filings (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.
Personalis Inc's Position in Industry Market Structure
Market-capitalization share and concentration across all 42 companies in Personalis Inc's industry classification, broader than the peer set above. Market cap in millions of $.Personalis Inc ranks #21 of 42 companies by market capitalization in its industry, holding 0.49 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 860, indicating a unconcentrated market structure (U.S. antitrust guidance: below 1,500 unconcentrated, 1,500 to 2,500 moderately concentrated, above 2,500 highly concentrated).
| Rank | Company | Market Cap | Industry Share |
|---|---|---|---|
| 1 | Natera Inc | 58,913 | 16.93 % |
| 2 | Iqvia Holdings Inc | 45,638 | 13.12 % |
| 3 | Ge Healthcare Technologies Inc | 30,422 | 8.74 % |
| 4 | Quest Diagnostics Inc | 26,362 | 7.58 % |
| 5 | Incyte Corporation | 1,234 | 5.2% |
| 6 | Labcorp Holdings Inc | 1,234 | 5.2% |
| 7 | Guardant Health Inc | 1,234 | 5.2% |
| 8 | Koninklijke Philips Nv | 1,234 | 5.2% |
| 9 | Medpace Holdings Inc | 1,234 | 5.2% |
| 10 | Charles River Laboratories International inc | 1,234 | 5.2% |
| 21 | Personalis Inc | 1,712 | 0.49 % |
Market cap and industry share for the rest of Personalis Inc's industry peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2026-09-28.
Personalis Inc's Same-Size Peers & Stock Performance
Peers chosen by closeness in market-cap rank within the same industry classification (not the named-competitor list above). Trailing 12-month total return, 3-month price momentum, beta and Sharpe ratio vs the broad U.S. market.| Rank | Company | Market Cap | TTM Return |
|---|---|---|---|
| 16 | Veracyte Inc | 3,739 | 38.82 % |
| 17 | Caredx Inc | 3,409 | 329.19 % |
| 18 | Butterfly Network Inc | 2,443 | 375.52 % |
| 19 | Viridian Therapeutics Inc | 2,064 | 5.82 % |
| 20 | Fortrea Holdings Inc | 1,234 | 12.3% |
| 21 | Personalis Inc | 1,712 | 166.23 % |
| 22 | Absci Corp | 1,234 | 12.3% |
| 23 | Castle Biosciences Inc | 1,234 | 12.3% |
| 24 | Lumexa Imaging Holdings Inc | 1,234 | 12.3% |
| 25 | Lightwave Logic Inc | 1,234 | 12.3% |
| 26 | Fulgent Genetics Inc | 1,234 | 12.3% |
Market cap, return, momentum, beta and Sharpe ratio for the rest of Personalis Inc's same-size peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation); returns and risk metrics as of 2026-09-28. Beta and Sharpe ratio are versus the broad U.S. equity market, not this industry.
Personalis Inc's Profitability & Cost Structure
Trailing 12-month margins from SEC-filed financials. Operating margin is compared to the Medical Laboratories industry median; gross margin, EBITDA margin and capital intensity are compared to the live industry average (58 companies).| Metric | Company | Industry | Difference |
|---|---|---|---|
| Gross Margin | 12.69 % | 43.57 % (avg) | -30.9 pp |
| Operating Margin | -164.07 % | industry median | -135.1 pp |
| EBITDA Margin | -139.60 % | -4.90 % (avg) | -134.7 pp |
| Capital Intensity (Capex / Revenue) | 12.45 % | 9.54 % (avg) | +2.9 pp |
Source: CSIMarket API, trailing 12 months. SG&A and R&D as a share of revenue have limited coverage as this data is backfilled and appear only where reported. Higher capital intensity is not inherently negative; it reflects the industry's asset requirements.
Personalis Inc's Valuation vs Competitive Position
Valuation multiples vs the Medical Laboratories industry average (58 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 37.0x | - |
| EV / EBITDA | - | 18.0x | - |
| P/B | 4.9x | 2.9x | +2.0x |
| Return on Equity | -46.47 % | industry aggregate | -49.44 % |
| Return on Invested Capital | -23.14 % | -4.04 % (avg) | -19.10 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
Personalis Inc's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in SEC filings.| Metric | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|
| Revenue Growth | - | - | 8.70 % | -23.92 % | 12.97 % | 15.15 % | -17.69 % |
| Operating Margin | - | -53.59 % | -76.44 % | -177.61 % | -149.61 % | -80.68 % | -126.43 % |
| Return on Invested Capital | - | -13.93 % | -9.42 % | -20.88 % | -29.69 % | -20.07 % | -19.54 % |
| P/E | - | - | - | - | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
Personalis Inc's Strategic Group Map
Every company in Personalis Inc's industry and named-competitor list, plotted by trailing 12-month revenue growth and operating margin. Personalis Inc is shown in red; its closest peers by combined growth, margin and ROIC (the Similar Growth & Profitability group above) are labeled.
Source: CSIMarket API, trailing 12 months. Extreme outlier values (from near-zero-revenue companies) are excluded from the plotted cloud but never from the highlighted company or its labeled peers.
Personalis Inc's BCG Growth-Share Matrix
Relative market share (vs Personalis Inc's largest competitor by market cap) against industry revenue growth, using the standard textbook thresholds (1.0x share, 10% growth) a common framework, not a precision instrument.
Personalis Inc falls in the Dog quadrant: relative market share of 0.03x vs its largest competitor, in an industry growing revenue 5.8% (median, trailing 12 months).
Source: CSIMarket API (market-cap share and industry revenue growth). The 10% growth and 1.0x share lines are standard textbook thresholds, not derived from this industry's own distribution.
Personalis Inc's Competitive Forces (Porter's Five Forces)
Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.| Force | Assessment | Basis |
|---|---|---|
| Competitive Rivalry | High | Industry HHI of 860 (see Industry Market Structure & Concentration above) |
| Barriers to Entry | High (capital intensive) | Capital intensity (capex / revenue) of 12.45 % vs industry average 9.54 % (see Profitability & Cost Structure above) |
| Supplier Power | Not covered on this page | See Personalis Inc's dedicated suppliers page for concentration and dependency data |
| Buyer Power | Not covered on this page | See Personalis Inc's dedicated customers page for concentration and dependency data |
| Threat of Substitutes | - | No systematic data source for cross-product substitution exists in this system; not estimated |
Note: this is a partial, data-grounded application of the framework, not a complete strategic assessment. Rivalry and barriers-to-entry readings are mechanical translations of the HHI and capital-intensity figures shown elsewhere on this page, not independent judgments.
Personalis Inc's Industry Attractiveness & Competitive Strength
A CSIMarket composite, not a standard field: each axis is an equal-weighted average of three factors already shown elsewhere on this page (industry growth, industry profitability and rivalry for attractiveness; relative market share, profitability and growth vs industry for strength). Disclosed as a designed methodology, not a precision measurement.
Personalis Inc falls in the Low attractiveness / Low strength cell: Harvest / Divest.
Source: CSIMarket API, trailing 12 months. Each axis score is a simple 1(low)/2(medium)/3(high) average across its three inputs -- a transparent, disclosed simplification, not a validated academic scoring model.
Personalis Inc's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
- Latest-quarter revenue run-rate is accelerating (+28.4% annualized vs trailing 12 months).
- Outperforming the U.S.A. 500 over the trailing 12 months.
Weaknesses
- Operating margin 135.1 points below the industry median.
- Return on equity 49.4 points below the industry aggregate.
- Low relative market share vs the industry leader (0.03x).
- Piotroski F-Score of 2 or below, the standard financial-distress signal.
Opportunities
No rule matched.
Threats
- High capital intensity requires continuous reinvestment just to keep pace with the industry.
Methodology: mechanical, rule-based SWOT. Each bullet reuses a figure already sourced and cited elsewhere on this page; nothing here is generated narrative or independent analyst judgment.
Personalis Inc's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| Personalis Inc | 2.12 | 5.87 | 0.00 |
| Natera Inc | - | 3.14 | 0.05 |
| Illumina Inc | - | 1.74 | 0.75 |
| Guardant Health Inc | 2.56 | 4.29 | - |
| Exact Sciences Corporation | 1.22 | 2.68 | 0.95 |
| Grail Inc | 4.14 | 10.58 | - |
Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
Personalis Inc's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| Personalis Inc | Q2 2026 | +30.0 % | - |
| Natera Inc | Q2 2026 | +37.7 % | - |
| Illumina Inc | Q2 2026 | +9.4 % | -11.9 % |
| Guardant Health Inc | Q2 2026 | +44.3 % | - |
| Exact Sciences Corporation | Q4 2025 | +23.1 % | - |
| Grail Inc | Q2 2026 | +25.7 % | - |
| PEERS TOTAL | +18.2 % | - |
Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
Personalis Inc's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| Personalis Inc | Q2 2026 | +41.5 % | +1,204.1 % |
| Natera Inc | Q2 2026 | -99.3 % | +144.9 % |
| Illumina Inc | Q2 2026 | +6.9 % | +33.3 % |
| Guardant Health Inc | Q2 2026 | +42.8 % | +108.2 % |
| Exact Sciences Corporation | Q4 2025 | +19.5 % | - |
| Grail Inc | Q2 2026 | - | +17.1 % |
Personalis Inc's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| Personalis Inc | - | - | - |
| Natera Inc | - | - | - |
| Illumina Inc | 12.68% | 19.61% | 31.08% |
| Guardant Health Inc | - | - | - |
| Exact Sciences Corporation | - | - | - |
| Grail Inc | - | - | - |
ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
Personalis Inc's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| Personalis Inc | - | 24.70 |
| Natera Inc | - | 21.79 |
| Illumina Inc | 50.92 | 9.26 |
| Guardant Health Inc | - | 19.91 |
| Exact Sciences Corporation | - | 6.04 |
| Grail Inc | - | 34.60 |
| PEERS AVERAGE | - | 9.29 |
P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.