Orchard Therapeutics Plc's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of Orchard Therapeutics Plc (ORTX) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
Key Findings: Orchard Therapeutics Plc vs Its Competitors
- TTM: Trailing 12-month revenue of 22M vs 95,684M combined for tracked competitors (0.0% combined share).
- Trending: Latest-quarter revenue run-rate is accelerating (+15.4% annualized vs trailing 12 months), vs decelerating (-64.1%) for its tracked peer group.
- Growth: Orchard Therapeutics Plc generated 9.1% revenue growth year over year in Q3 2023, vs 2.0% for its tracked competitors combined.
- Profitability: Its -560.4% net margin compares with 4.9% for the peer group.
- Peer revenue share: Orchard Therapeutics Plc accounted for 0.1% of combined revenue among its tracked peer group, up from 0.1% a year earlier.
- Peer differentiation: Revenue per employee of $0.22M compares with $0.91M for the peer group (0.2x).
Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).
ORTX Sales vs. its Competitors, Q3 2023
Orchard Therapeutics Plc reported revenue growth of 9.09 % year on year in Q3 2023, above its competitors' combined revenue growth of 2.03 %.
With a net margin of -560.44 %, Orchard Therapeutics Plc reported lower profitability than its competitors (4.89 %).
Orchard Therapeutics Plc generated 0.07 % of the combined sales of its peer group, up from 0.07 % a year earlier.
Orchard Therapeutics Plc vs. its Competitors, Q3 2023
Revenue growth, year on year
Net margin
Revenue run-rate vs trailing 12 months
TTM net margin
TTM = trailing twelve months. Run-rate annualizes the latest quarter (×4) and compares it to TTM. In millions of $. High-Confidence Competitors are named as a competitor directly in an SEC filing; Similar-Size Competitors are the closest peers by market-cap rank within the same industry; Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC, all independent of the competitor list.
TTM revenue, latest-quarter run-rate and net income/margin benchmarked across Orchard Therapeutics Plc and its 4 competitor groupings. Available under Commercial License.
| Entity | TTM Revenue | Rev Run-rate vs TTM |
|---|---|---|
| Orchard Therapeutics Plc | $12,345M | +12.3% · Accelerating |
| Competitors combined | $12,345M | +12.3% · Accelerating |
| High-Confidence Competitors (3) | $12,345M | +12.3% · Accelerating |
| Similar Growth & Profitability (5) | $12,345M | +12.3% · Accelerating |
TTM revenue, run-rate and net margin benchmarking across Orchard Therapeutics Plc's competitor groups requires a Commercial License.
For context: the Biotechnology & Pharmaceuticals industry grew revenue 20.7% year over year, combined, vs 9.1% for Orchard Therapeutics Plc. Orchard Therapeutics Plc's share of combined industry revenue moved from 0.02% to 0.01%, a gain of 0.00 percentage points.
Orchard Therapeutics Plc's Competitor Quality Breadth
Share of each group, trailing 12 months: profitable (net margin > 0), expanding (revenue growth > 0), growing faster than the industry's own median, and financially distressed (Piotroski F-Score of 2 or below).
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| Orchard Therapeutics Plc | No | Yes | Yes | No |
| Competitors combined (45) | ||||
| High-Confidence Competitors (3) | ||||
| Similar Growth & Profitability (8) | 0.00 % (0 of 8) | 75.00 % (6 of 8) | 62.50 % (5 of 8) | 42.90 % (3 of 7) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
ORTX Stock Performance relative to its Competitors
ORTX Stock Performance relative to High-Confidence Competitors
ORTX Stock Performance relative to Similar Growth & Profitability Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Iovance Biotherapeutics inc | 282.9% | Outperformed |
| 2 | Revolution Medicines Inc | 282.9% | Outperformed |
| 3 | Century Therapeutics inc | 282.9% | Outperformed |
| 4 | Krystal Biotech Inc | 282.9% | Outperformed |
| 5 | Contextlogic Inc | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for Orchard Therapeutics Plc's best-performing tracked competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Publicly Traded Peers of Orchard Therapeutics Plc
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
| Orchard Therapeutics Plc | 381.41 | 21.84 |
| Novartis Ag | 286,994.00 | 56,674.00 |
| Gilead Sciences Inc | 185,927.94 | 30,457.00 |
| Seagen Inc | 43,034.00 | 2,300.35 |
| Revolution Medicines Inc | 42,833.55 | 29.51 |
| Biomarin Pharmaceutical Inc | 11,561.06 | 3,406.61 |
| SUBTOTAL | 606,944.63 | 95,762.78 |
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Sources: Orchard Therapeutics Plc's official press releases and regulatory filings; CSIMarket.com's market research; and the financial filings and press releases of the other companies cited.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Orchard Therapeutics Plc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
Orchard Therapeutics Plc's Competitors Named by the Company
Competitive relationships identified from SEC filings and corroborating sources, each with a basis and confidence.| Competitor | Basis | Confidence |
|---|---|---|
| Passage Bio Inc | Named by the company | 85% |
| Sana Biotechnology Inc | Named by the company | 85% |
| Biomarin Pharmaceutical Inc | Named by the company | 85% |
Filing basis, confidence, active dates and source counts for Orchard Therapeutics Plc's named competitors require a Commercial License.
Methodology: relationships are extracted from SEC filings (named-competitor disclosures) and corroborating sources. Named by the company = explicitly disclosed as a competitor; Inferred = derived from corroborating signals. Confidence reflects evidence strength.
Orchard Therapeutics Plc's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| Orchard Therapeutics Plc | 381 | 218,390 | -729,210 |
| Novartis Ag | 286,994 | 752,973 | 185,566 |
| Gilead Sciences Inc | 185,928 | 1,791,588 | -190,588 |
| Seagen Inc | 43,034 | 1,916,959 | -625,187 |
| Revolution Medicines Inc | 42,834 | 33,420 | -2,002,588 |
| Biomarin Pharmaceutical Inc | 11,561 | 1,057,626 | 22,655 |
| PEERS TOTAL | 606,563 | 914,973 | 54,663 |
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Orchard Therapeutics Plc's Geographic Revenue Exposure vs Peers
Revenue by country/region as reported in each company's most recent filing. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.| Company | Largest Market |
|---|---|
| Gilead Sciences Inc | United States 70.78 % |
| Krystal Biotech Inc | United States 75.19 % |
| Iovance Biotherapeutics inc | US 98.66 % |
| 4d Molecular Therapeutics Inc | JP 97.05 % |
| Caribou Biosciences Inc | United States 94.16 % |
Source: revenue geography as reported in each company's SEC filings (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.
Orchard Therapeutics Plc's Business Segment Mix vs Peers
Revenue by operating segment, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).| Company | Largest Segment |
|---|---|
| Biomarin Pharmaceutical Inc | Reportable 100.00 % |
| Iovance Biotherapeutics inc | Single reportable segment 100.00 % |
| Immunocore Holdings Plc | Reportable 100.00 % |
| Ginkgo Bioworks Holdings Inc | Reportable 100.00 % |
| Prime Medicine Inc | Reportable 100.00 % |
Source: operating segment revenue as reported in each company's SEC filings (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).
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Orchard Therapeutics Plc's Profitability & Cost Structure
Trailing 12-month margins from SEC-filed financials. Operating margin is compared to the Biotechnology & Pharmaceuticals industry median; gross margin, EBITDA margin and capital intensity are compared to the live industry average (93 companies).| Metric | Company | Industry | Difference |
|---|---|---|---|
| Gross Margin | 69.17 % | 68.46 % (avg) | +0.7 pp |
| Operating Margin | -467.13 % | industry median | -163.2 pp |
| EBITDA Margin | -313.65 % | -0.94 % (avg) | -312.7 pp |
| Capital Intensity (Capex / Revenue) | - | 6.74 % (avg) | - |
Source: CSIMarket API, trailing 12 months. SG&A and R&D as a share of revenue have limited coverage as this data is backfilled and appear only where reported. Higher capital intensity is not inherently negative; it reflects the industry's asset requirements.
Orchard Therapeutics Plc's Valuation vs Competitive Position
Valuation multiples vs the Biotechnology & Pharmaceuticals industry average (93 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 26.7x | - |
| EV / EBITDA | - | 21.3x | - |
| P/B | 2.0x | 5.1x | -3.1x |
| Return on Equity | -74.94 % | industry aggregate | -81.06 % |
| Return on Invested Capital | -36.47 % | -6.17 % (avg) | -30.30 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
Orchard Therapeutics Plc's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in SEC filings.| Metric | 2019 | 2020 | 2021 | 2022 |
|---|---|---|---|---|
| Revenue Growth | - | - | - | - |
| Operating Margin | - | - | - | -560.97 % |
| Return on Invested Capital | -25.53 % | -32.26 % | -24.67 % | -37.25 % |
| P/E | - | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
Orchard Therapeutics Plc's Strategic Group Map
Every company in Orchard Therapeutics Plc's industry and named-competitor list, plotted by trailing 12-month revenue growth and operating margin. Orchard Therapeutics Plc is shown in red; its closest peers by combined growth, margin and ROIC (the Similar Growth & Profitability group above) are labeled.
Source: CSIMarket API, trailing 12 months. Extreme outlier values (from near-zero-revenue companies) are excluded from the plotted cloud but never from the highlighted company or its labeled peers.
Orchard Therapeutics Plc's Industry Attractiveness & Competitive Strength
A CSIMarket composite, not a standard field: each axis is an equal-weighted average of three factors already shown elsewhere on this page (industry growth, industry profitability and rivalry for attractiveness; relative market share, profitability and growth vs industry for strength). Disclosed as a designed methodology, not a precision measurement.
Orchard Therapeutics Plc falls in the Low attractiveness / Medium strength cell: Harvest.
Source: CSIMarket API, trailing 12 months. Each axis score is a simple 1(low)/2(medium)/3(high) average across its three inputs -- a transparent, disclosed simplification, not a validated academic scoring model.
Orchard Therapeutics Plc's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) — not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
- Latest-quarter revenue run-rate is accelerating (+15.4% annualized vs trailing 12 months).
Weaknesses
- Operating margin 163.2 points below the industry median.
- Return on equity 81.1 points below the industry aggregate.
Opportunities
- Industry revenue growing at a healthy 10.0% median pace.
- A meaningful share of tracked competitors (52.40 %) show financial-distress signals, a possible opening to gain share.
Threats
- Tracked peer group's revenue run-rate is broadly decelerating (-64.1% annualized).
Methodology: mechanical, rule-based SWOT. Each bullet reuses a figure already sourced and cited elsewhere on this page; nothing here is generated narrative or independent analyst judgment.
Orchard Therapeutics Plc's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| Orchard Therapeutics Plc | 0.87 | 3.03 | 0.38 |
| Novartis Ag | 0.42 | 1.12 | 0.02 |
| Gilead Sciences Inc | - | 1.54 | 1.27 |
| Seagen Inc | 0.43 | 3.22 | - |
| Revolution Medicines Inc | 1.35 | 7.28 | 0.07 |
| Biomarin Pharmaceutical Inc | 1.41 | 4.08 | 0.30 |
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Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
Orchard Therapeutics Plc's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| Orchard Therapeutics Plc | Q3 2023 | +9.1 % | - |
| Novartis Ag | Q4 2025 | +9.6 % | +17.0 % |
| Gilead Sciences Inc | Q2 2026 | +10.2 % | - |
| Seagen Inc | Q3 2023 | +27.1 % | - |
| Revolution Medicines Inc | Q2 2026 | - | - |
| Biomarin Pharmaceutical Inc | Q2 2026 | +19.9 % | -81.4 % |
| PEERS TOTAL | +10.8 % | -82.6 % |
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Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
Orchard Therapeutics Plc's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| Orchard Therapeutics Plc | Q3 2023 | +6.1 % | -97.2 % |
| Novartis Ag | Q4 2025 | +18.3 % | +13.3 % |
| Gilead Sciences Inc | Q2 2026 | +5.2 % | +30.8 % |
| Seagen Inc | Q3 2023 | +52.8 % | +175.7 % |
| Revolution Medicines Inc | Q2 2026 | - | -69.3 % |
| Biomarin Pharmaceutical Inc | Q2 2026 | +35.1 % | +97.2 % |
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Orchard Therapeutics Plc's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| Orchard Therapeutics Plc | - | - | - |
| Novartis Ag | 12.59% | 12.62% | 30.00% |
| Gilead Sciences Inc | - | - | - |
| Seagen Inc | - | - | - |
| Revolution Medicines Inc | - | - | - |
| Biomarin Pharmaceutical Inc | 0.82% | 0.91% | 1.18% |
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ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
Orchard Therapeutics Plc's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| Orchard Therapeutics Plc | - | 17.46 |
| Novartis Ag | 20.52 | 5.06 |
| Gilead Sciences Inc | - | 6.10 |
| Seagen Inc | - | 18.71 |
| Revolution Medicines Inc | - | 1,451.49 |
| Biomarin Pharmaceutical Inc | 165.14 | 3.39 |
| PEERS AVERAGE | 107.48 | 6.34 |
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P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.