International Stem Cell's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of International Stem Cell (ISCO) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
Key Findings: International Stem Cell vs Its Competitors
- TTM: Trailing 12-month revenue of 10M vs 1,735M combined for tracked competitors (0.5% combined share).
- Trending: Latest-quarter revenue run-rate is accelerating (+12.5% annualized vs trailing 12 months), vs accelerating (+8.8%) for its tracked peer group.
- Growth: International Stem Cell generated 9.3% revenue growth year over year in Q2 2026, vs 20.0% for its tracked competitors combined.
- Profitability: Its -2.7% net margin compares with -91.1% for the peer group.
- Scale: International Stem Cell ranks #440 of 544 companies by market capitalization in the Major Pharmaceutical Preparations industry, holding 0.0% of industry market cap.
- Peer revenue share: International Stem Cell accounted for 0.6% of combined revenue among its tracked peer group, down from 0.6% a year earlier.
- Peer differentiation: Revenue per employee of $0.29M compares with $0.26M for the peer group (1.1x).
Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).
ISCO Sales vs. its Competitors, Q2 2026
International Stem Cell reported revenue growth of 9.32 % year on year in Q2 2026, below its competitors' combined revenue growth of 20.01 %.
With a net margin of -2.65 %, International Stem Cell achieved higher profitability than its competitors (-91.13 %).
International Stem Cell generated 0.56 % of the combined sales of its peer group, down from 0.62 % a year earlier.
International Stem Cell vs. its Competitors, Q2 2026
Revenue growth, year on year
Net margin
Revenue run-rate vs trailing 12 months
TTM net margin
TTM = trailing twelve months. Run-rate annualizes the latest quarter (×4) and compares it to TTM. In millions of $. High-Confidence Competitors are named as a competitor directly in an SEC filing; Similar-Size Competitors are the closest peers by market-cap rank within the same industry; Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC, all independent of the competitor list.
TTM revenue, latest-quarter run-rate and net income/margin benchmarked across International Stem Cell and its 4 competitor groupings. Available under Commercial License.
| Entity | TTM Revenue | Rev Run-rate vs TTM |
|---|---|---|
| International Stem Cell Corporation | $12,345M | +12.3% · Accelerating |
| Competitors combined | $12,345M | +12.3% · Accelerating |
| Similar-Size Competitors (9) | $12,345M | +12.3% · Accelerating |
| Similar Growth & Profitability (2) | $12,345M | +12.3% · Accelerating |
TTM revenue, run-rate and net margin benchmarking across International Stem Cell's competitor groups requires a Commercial License.
For context: the Major Pharmaceutical Preparations industry grew revenue 7.2% year over year, combined, vs 9.3% for International Stem Cell. International Stem Cell's share of combined industry revenue moved from 0.00% to 0.00%, a gain of 0.00 percentage points.
International Stem Cell's Competitor Quality Breadth
Share of each group, trailing 12 months: profitable (net margin > 0), expanding (revenue growth > 0), growing faster than the industry's own median, and financially distressed (Piotroski F-Score of 2 or below).
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| International Stem Cell Corporation | No | Yes | No | No |
| Competitors combined (43) | ||||
| Similar-Size Competitors (9) | ||||
| Similar Growth & Profitability (8) | 25.00 % (2 of 8) | 62.50 % (5 of 8) | 0.00 % (0 of 8) | 0.00 % (0 of 8) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
ISCO Stock Performance relative to its Competitors
ISCO Stock Performance relative to Similar-Size Competitors
ISCO Stock Performance relative to Similar Growth & Profitability Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Praxis Precision Medicines Inc | 282.9% | Outperformed |
| 2 | Immix Biopharma Inc | 282.9% | Outperformed |
| 3 | Longeveron Inc | 282.9% | Outperformed |
| 4 | Avadel Pharmaceuticals Plc | 282.9% | Outperformed |
| 5 | Merus N v | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for International Stem Cell's best-performing tracked competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Publicly Traded Peers of International Stem Cell Corporation
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
| International Stem Cell Corporation | 2.56 | 9.51 |
| Praxis Precision Medicines Inc | 8,321.38 | 8.55 |
| Merus N v | 6,810.81 | 56.61 |
| Avadel Pharmaceuticals Plc | 2,189.59 | 248.76 |
| Vericel Corporation | 2,105.03 | 306.30 |
| Mesoblast Limited | 1,751.30 | 17.20 |
| SUBTOTAL | 27,087.95 | 2,306.54 |
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Sources: International Stem Cell Corporation's official press releases and regulatory filings; CSIMarket.com's market research; and the financial filings and press releases of the other companies cited.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on International Stem Cell Corporation versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
International Stem Cell's Business Segment Mix vs Peers
Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).| Company | Largest Segment |
|---|---|
| International Stem Cell Corporation | Biomedical Market 93.74 % |
| Avadel Pharmaceuticals Plc | Reportable 100.00 % |
| Ardelyx inc | Reportable 100.00 % |
| Geron Corporation | Reportable 99.93 % |
| 2seventy Bio Inc | Reportable 100.00 % |
| Longeveron Inc | Reportable Segment Aggregation Before Other Operating Segment 100.00 % |
Source: operating segment revenue as reported in each company's SEC filings (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).
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International Stem Cell's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| International Stem Cell Corporation | 3 | 288,303 | -9,939 |
| Praxis Precision Medicines Inc | 8,321 | 50,911 | -2,018,607 |
| Merus N v | 6,811 | 539,105 | -3,629,857 |
| Avadel Pharmaceuticals Plc | 2,190 | 1,615,338 | -1,805 |
| Vericel Corporation | 2,105 | 769,606 | 60,857 |
| Mesoblast Limited | 1,751 | 159,241 | -945,759 |
| PEERS TOTAL | 27,085 | 255,026 | -316,964 |
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International Stem Cell's Geographic Revenue Exposure vs Peers
Revenue by country/region as reported in each company's most recent filing. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.| Company | Largest Market |
|---|---|
| Ultragenyx Pharmaceutical Inc | North America 43.38 % |
| Durect Corp | Europe 72.48 % |
Source: revenue geography as reported in each company's SEC filings (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.
International Stem Cell's Position in Industry Market Structure
Market-capitalization share and concentration across all 498 companies in International Stem Cell's industry classification, broader than the peer set above. Market cap in millions of $.International Stem Cell ranks #440 of 498 companies by market capitalization in its industry, holding 0.00 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 823, indicating a unconcentrated market structure (U.S. antitrust guidance: below 1,500 unconcentrated, 1,500 to 2,500 moderately concentrated, above 2,500 highly concentrated).
| Rank | Company | Market Cap | Industry Share |
|---|---|---|---|
| 1 | Eli Lilly And Company | 1,058,838 | 19.26 % |
| 2 | Johnson and Johnson | 663,585 | 12.07 % |
| 3 | Beone Medicines Ltd | 552,468 | 10.05 % |
| 4 | Abbvie Inc | 471,582 | 8.58 % |
| 5 | Merck and Co Inc | 1,234 | 5.2% |
| 6 | Novartis Ag | 1,234 | 5.2% |
| 7 | Abbott Laboratories | 1,234 | 5.2% |
| 8 | Novo Nordisk A | 1,234 | 5.2% |
| 9 | Pfizer Inc | 1,234 | 5.2% |
| 10 | Vertex Pharmaceuticals Inc | 1,234 | 5.2% |
| 440 | International Stem Cell Corporation | 3 | 0.00 % |
Market cap and industry share for the rest of International Stem Cell's industry peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2026-09-25.
International Stem Cell's Same-Size Peers & Stock Performance
Peers chosen by closeness in market-cap rank within the same industry classification (not the named-competitor list above). Trailing 12-month total return, 3-month price momentum, beta and Sharpe ratio vs the broad U.S. market.| Rank | Company | Market Cap | TTM Return |
|---|---|---|---|
| 435 | 60 Degrees Pharmaceuticals Inc | 3 | -79.14 % |
| 436 | Revelation Biosciences Inc | 3 | -84.29 % |
| 437 | Azitra Inc | 3 | -76.56 % |
| 438 | Cadrenal Therapeutics Inc | 3 | -92.32 % |
| 439 | Moleculin Biotech Inc | 1,234 | 12.3% |
| 440 | International Stem Cell Corporation | 3 | - |
| 441 | Immuron Limited | 1,234 | 12.3% |
| 442 | Cv Sciences Inc | 1,234 | 12.3% |
| 443 | Alaunos Therapeutics Inc | 1,234 | 12.3% |
| 444 | Hcw Biologics Inc | 1,234 | 12.3% |
| 445 | Bioxytran Inc | 1,234 | 12.3% |
Market cap, return, momentum, beta and Sharpe ratio for the rest of International Stem Cell's same-size peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation); returns and risk metrics as of 2026-09-28. Beta and Sharpe ratio are versus the broad U.S. equity market, not this industry.
International Stem Cell's Profitability & Cost Structure
Trailing 12-month margins from SEC-filed financials. Operating margin is compared to the Major Pharmaceutical Preparations industry median; gross margin, EBITDA margin and capital intensity are compared to the live industry average (341 companies).| Metric | Company | Industry | Difference |
|---|---|---|---|
| Gross Margin | 58.27 % | 64.89 % (avg) | -6.6 pp |
| Operating Margin | -1.97 % | industry median | +51.7 pp |
| EBITDA Margin | -0.98 % | -7.21 % (avg) | +6.2 pp |
| Capital Intensity (Capex / Revenue) | 0.53 % | 4.92 % (avg) | -4.4 pp |
Source: CSIMarket API, trailing 12 months. SG&A and R&D as a share of revenue have limited coverage as this data is backfilled and appear only where reported. Higher capital intensity is not inherently negative; it reflects the industry's asset requirements.
International Stem Cell's Valuation vs Competitive Position
Valuation multiples vs the Major Pharmaceutical Preparations industry average (341 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 25.1x | - |
| EV / EBITDA | - | 17.3x | - |
| P/B | -0.4x | 4.5x | -4.8x |
| Return on Equity | 8.06 % | industry aggregate | -9.19 % |
| Return on Invested Capital | 3.82 % | -2.95 % (avg) | 6.77 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
International Stem Cell's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in SEC filings.| Metric | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|
| Revenue Growth | 48.73 % | -14.58 % | -24.75 % | 0.67 % | 13.99 % | -4.78 % | 16.64 % | 0.17 % |
| Operating Margin | -31.33 % | -60.47 % | -39.53 % | -26.77 % | -2.24 % | -8.51 % | -0.75 % | -0.11 % |
| Return on Invested Capital | -79.90 % | -143.46 % | 658.80 % | 59.87 % | 4.65 % | 19.99 % | 1.90 % | 0.23 % |
| P/E | - | - | - | - | - | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
International Stem Cell's Strategic Group Map
Every company in International Stem Cell's industry and named-competitor list, plotted by trailing 12-month revenue growth and operating margin. International Stem Cell is shown in red; its closest peers by combined growth, margin and ROIC (the Similar Growth & Profitability group above) are labeled.
Source: CSIMarket API, trailing 12 months. Extreme outlier values (from near-zero-revenue companies) are excluded from the plotted cloud but never from the highlighted company or its labeled peers.
International Stem Cell's BCG Growth-Share Matrix
Relative market share (vs International Stem Cell's largest competitor by market cap) against industry revenue growth, using the standard textbook thresholds (1.0x share, 10% growth) a common framework, not a precision instrument.
International Stem Cell falls in the Dog quadrant: relative market share of 0.00x vs its largest competitor, in an industry growing revenue 8.0% (median, trailing 12 months).
Source: CSIMarket API (market-cap share and industry revenue growth). The 10% growth and 1.0x share lines are standard textbook thresholds, not derived from this industry's own distribution.
International Stem Cell's Competitive Forces (Porter's Five Forces)
Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.| Force | Assessment | Basis |
|---|---|---|
| Competitive Rivalry | High | Industry HHI of 823 (see Industry Market Structure & Concentration above) |
| Barriers to Entry | Lower than typical for the industry | Capital intensity (capex / revenue) of 0.53 % vs industry average 4.92 % (see Profitability & Cost Structure above) |
| Supplier Power | Not covered on this page | See International Stem Cell's dedicated suppliers page for concentration and dependency data |
| Buyer Power | Not covered on this page | See International Stem Cell's dedicated customers page for concentration and dependency data |
| Threat of Substitutes | - | No systematic data source for cross-product substitution exists in this system; not estimated |
Note: this is a partial, data-grounded application of the framework, not a complete strategic assessment. Rivalry and barriers-to-entry readings are mechanical translations of the HHI and capital-intensity figures shown elsewhere on this page, not independent judgments.
International Stem Cell's Industry Attractiveness & Competitive Strength
A CSIMarket composite, not a standard field: each axis is an equal-weighted average of three factors already shown elsewhere on this page (industry growth, industry profitability and rivalry for attractiveness; relative market share, profitability and growth vs industry for strength). Disclosed as a designed methodology, not a precision measurement.
International Stem Cell falls in the Low attractiveness / Medium strength cell: Harvest.
Source: CSIMarket API, trailing 12 months. Each axis score is a simple 1(low)/2(medium)/3(high) average across its three inputs -- a transparent, disclosed simplification, not a validated academic scoring model.
International Stem Cell's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
- Operating margin 51.7 points above the industry median.
- Latest-quarter revenue run-rate is accelerating (+12.5% annualized vs trailing 12 months).
Weaknesses
- Return on equity 9.2 points below the industry aggregate.
- Low relative market share vs the industry leader (0.00x).
Opportunities
- A meaningful share of tracked competitors (52.40 %) show financial-distress signals, a possible opening to gain share.
Threats
No rule matched.
Methodology: mechanical, rule-based SWOT. Each bullet reuses a figure already sourced and cited elsewhere on this page; nothing here is generated narrative or independent analyst judgment.
International Stem Cell's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| International Stem Cell Corporation | 0.21 | 0.77 | - |
| Praxis Precision Medicines Inc | 11.53 | 11.58 | - |
| Merus N v | 3.67 | 7.20 | - |
| Avadel Pharmaceuticals Plc | 1.14 | 2.76 | - |
| Vericel Corporation | 2.24 | 5.03 | - |
| Mesoblast Limited | 1.57 | 1.99 | 0.09 |
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Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
International Stem Cell's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| International Stem Cell Corporation | Q2 2026 | +9.3 % | - |
| Praxis Precision Medicines Inc | Q2 2026 | - | - |
| Merus N v | Q3 2025 | +3.2 % | - |
| Avadel Pharmaceuticals Plc | Q3 2025 | +55.3 % | - |
| Vericel Corporation | Q2 2026 | +22.5 % | - |
| Mesoblast Limited | Q2 2025 | +191.4 % | - |
| PEERS TOTAL | +14.8 % | - |
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Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
International Stem Cell's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| International Stem Cell Corporation | Q2 2026 | +31.3 % | -65.6 % |
| Praxis Precision Medicines Inc | Q2 2026 | - | +1,717.9 % |
| Merus N v | Q3 2025 | - | +21.0 % |
| Avadel Pharmaceuticals Plc | Q3 2025 | -33.1 % | - |
| Vericel Corporation | Q2 2026 | +26.6 % | -76.2 % |
| Mesoblast Limited | Q2 2025 | - | +150.9 % |
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International Stem Cell's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| International Stem Cell Corporation | - | - | - |
| Praxis Precision Medicines Inc | - | - | - |
| Merus N v | - | - | - |
| Avadel Pharmaceuticals Plc | - | - | - |
| Vericel Corporation | 5.02% | 5.58% | 6.91% |
| Mesoblast Limited | - | - | - |
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ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
International Stem Cell's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| International Stem Cell Corporation | - | 0.27 |
| Praxis Precision Medicines Inc | - | 972.92 |
| Merus N v | - | 120.32 |
| Avadel Pharmaceuticals Plc | - | 8.80 |
| Vericel Corporation | 85.62 | 6.87 |
| Mesoblast Limited | - | 101.83 |
| PEERS AVERAGE | - | 11.74 |
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P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.