Hoth Therapeutics Inc's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of Hoth Therapeutics Inc (HOTH) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
API endpoints for this dataset
Hoth Therapeutics Inc's Competitor Quality Breadth
Group definitions: see Methodology: Performance Group Definitions.
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| Hoth Therapeutics Inc | - | - | - | Yes |
| Competitors combined (62) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
HOTH Stock Performance relative to its Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Regulus Therapeutics Inc | 282.9% | Outperformed |
| 2 | Silence Therapeutics Plc | 282.9% | Outperformed |
| 3 | Palvella Therapeutics Inc | 282.9% | Outperformed |
| 4 | Immunoprecise Antibodies Ltd | 282.9% | Outperformed |
| 5 | Liquidia Corporation | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for Hoth Therapeutics Inc's best-performing competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Hoth Therapeutics Inc's Comment on Competition and Industry Peers
Publicly Traded Peers of Hoth Therapeutics Inc
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
 Hoth Therapeutics Inc |
19.54 | - |
 Vertex Pharmaceuticals Inc |
139,617.37 | 12,951.60 |
 Regeneron Pharmaceuticals Inc |
95,499.36 | 16,896.20 |
 Alnylam Pharmaceuticals Inc |
21,525.96 | 5,013.24 |
 Arrowhead Pharmaceuticals Inc |
8,338.86 | 669.50 |
 Praxis Precision Medicines Inc |
8,087.45 | 8.55 |
| SUBTOTAL | 332,398.01 | 42,885.79 |
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Sources: see Methodology: Peer & Competitor Identification, Sourcing.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Hoth Therapeutics Inc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
Hoth Therapeutics Inc's Competitors Named by the Company
Competitive relationships identified from Hoth Therapeutics Inc reports and corroborating sources, each with a basis and confidence.| Competitor | Basis | Confidence |
|---|---|---|
| Voltron | Company report | 85% |
| Intrusion Inc | Company report | 85% |
Company report basis, confidence, active dates and source counts for Hoth Therapeutics Inc's named competitors require a Commercial License.
Methodology: see Methodology: Peer & Competitor Identification, Sourcing.
Hoth Therapeutics Inc's Business Segment Mix vs Peers
Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).| Company | Largest Segment |
|---|---|
| Vertex Pharmaceuticals Inc | Pharmaceuticals 100.00 % |
| Ionis Pharmaceuticals Inc | Ionis Operations 100.00 % |
| Ptc Therapeutics inc | Life Science Segment 100.00 % |
| Liquidia Corporation | Single reportable segment 100.00 % |
| Sarepta Therapeutics Inc | All Other Segments 100.00 % |
Source: operating segment revenue as reported in each company's reports (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).
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Hoth Therapeutics Inc's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| Hoth Therapeutics Inc | 20 | - | -2,220,184 |
| Vertex Pharmaceuticals Inc | 139,617 | 31,979,259 | 9,817,037 |
| Regeneron Pharmaceuticals Inc | 95,499 | 1,096,444 | 312,615 |
| Alnylam Pharmaceuticals Inc | 21,526 | 2,005,297 | 1,089,696 |
| Arrowhead Pharmaceuticals Inc | 8,339 | 941,624 | -382,736 |
| Praxis Precision Medicines Inc | 8,087 | 50,911 | -2,018,607 |
| PEERS TOTAL | 332,378 | 1,464,679 | 227,951 |
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Hoth Therapeutics Inc's Geographic Revenue Exposure vs Peers
Revenue by country/region as reported in each company's most recent report. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.| Company | Largest Market |
|---|---|
| Vertex Pharmaceuticals Inc | United States 63.04 % |
| Ptc Therapeutics inc | All Other Countries Other Than Russia Brazil and United States 18.85 % |
Source: revenue geography as reported in each company's reports (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.
Hoth Therapeutics Inc's Position in Industry Market Structure
Market-capitalization share and concentration across all 495 companies in Hoth Therapeutics Inc's industry classification, broader than the peer set above. Market cap in millions of $.Hoth Therapeutics Inc ranks #0 of 495 companies by market capitalization in its industry, holding 0.00 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 875, indicating a unconcentrated market structure (see Methodology: Market Structure & Concentration).
| Rank | Company | Market Cap | Industry Share |
|---|---|---|---|
| 1 | Eli Lilly And Company | 1,210,070 | 20.69 % |
| 2 | Johnson and Johnson | 674,004 | 11.53 % |
| 3 | Beone Medicines Ltd | 612,622 | 10.48 % |
| 4 | Abbvie Inc | 515,910 | 8.82 % |
| 5 | Merck and Co Inc | 1,234 | 5.2% |
| 6 | Novartis Ag | 1,234 | 5.2% |
| 7 | Abbott Laboratories | 1,234 | 5.2% |
| 8 | Novo Nordisk A | 1,234 | 5.2% |
| 9 | Pfizer Inc | 1,234 | 5.2% |
| 10 | Astrazeneca Plc | 1,234 | 5.2% |
| 0 | Hoth Therapeutics Inc | 13 | 0.00 % |
Market cap and industry share for the rest of Hoth Therapeutics Inc's industry peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2026-07-17.
Hoth Therapeutics Inc's Valuation vs Competitive Position
Valuation multiples vs the Major Pharmaceutical Preparations industry average (444 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns. See the full Major Pharmaceutical Preparations industry valuation benchmarks.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 26.6x | - |
| EV / EBITDA | - | 15.9x | - |
| P/B | 2.8x | 4.3x | -1.5x |
| Return on Equity | -199.23 % | industry aggregate | -215.58 % |
| Return on Invested Capital | -98.48 % | -9.83 % (avg) | -88.65 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
Hoth Therapeutics Inc's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in company reports.| Metric | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|
| Revenue Growth | - | - | - | - | - | - | - |
| Operating Margin | - | - | - | - | - | - | - |
| Return on Invested Capital | -94.88 % | -66.12 % | -46.81 % | -66.35 % | -34.79 % | -50.22 % | -69.32 % |
| P/E | - | - | - | - | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
Hoth Therapeutics Inc's Competitive Forces (Porter's Five Forces)
Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.| Force | Assessment | Basis |
|---|---|---|
| Competitive Rivalry | High | Industry HHI of 875 (see Industry Market Structure & Concentration above) |
Note: see Methodology: Porter's Five Forces. Supplier power and buyer power are covered on Hoth Therapeutics Inc's dedicated Suppliers and Customers pages, not here.
Hoth Therapeutics Inc's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
No rule matched.
Weaknesses
- Return on equity 215.6 points below the industry aggregate.
- Piotroski F-Score of 2 or below, the standard financial-distress signal.
Opportunities
- A meaningful share of competitors (50.00 %) show financial-distress signals, a possible opening to gain share.
Threats
No rule matched.
Methodology: see Methodology: SWOT Analysis.
Hoth Therapeutics Inc's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| Hoth Therapeutics Inc | 4.93 | 5.53 | - |
| Vertex Pharmaceuticals Inc | 1.30 | 2.83 | 0.06 |
| Regeneron Pharmaceuticals Inc | 0.58 | 3.56 | 0.06 |
| Alnylam Pharmaceuticals Inc | 1.07 | 2.82 | 0.59 |
| Arrowhead Pharmaceuticals Inc | 0.00 | 5.58 | 1.06 |
| Praxis Precision Medicines Inc | 11.53 | 11.58 | - |
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Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
Hoth Therapeutics Inc's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| Hoth Therapeutics Inc | Q2 2026 | - | - |
| Vertex Pharmaceuticals Inc | Q3 2026 | +11.8 % | -39.6 % |
| Regeneron Pharmaceuticals Inc | Q3 2026 | +36.3 % | +33.5 % |
| Alnylam Pharmaceuticals Inc | Q3 2026 | +16.7 % | +640.5 % |
| Arrowhead Pharmaceuticals Inc | Q2 2026 | +171.0 % | - |
| Praxis Precision Medicines Inc | Q2 2026 | - | - |
| PEERS TOTAL | +22.1 % | +108.4 % |
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Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
Hoth Therapeutics Inc's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| Hoth Therapeutics Inc | Q2 2026 | - | - |
| Vertex Pharmaceuticals Inc | Q3 2026 | +26.8 % | -4.4 % |
| Regeneron Pharmaceuticals Inc | Q3 2026 | +104.1 % | +49.1 % |
| Alnylam Pharmaceuticals Inc | Q3 2026 | +83.4 % | +475.1 % |
| Arrowhead Pharmaceuticals Inc | Q2 2026 | - | +63.0 % |
| Praxis Precision Medicines Inc | Q2 2026 | - | +1,717.9 % |
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Hoth Therapeutics Inc's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| Hoth Therapeutics Inc | - | - | - |
| Vertex Pharmaceuticals Inc | 14.16% | 16.63% | 20.08% |
| Regeneron Pharmaceuticals Inc | 11.50% | 13.00% | 15.07% |
| Alnylam Pharmaceuticals Inc | 46.08% | 63.14% | 159.72% |
| Arrowhead Pharmaceuticals Inc | - | - | - |
| Praxis Precision Medicines Inc | - | - | - |
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ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
Hoth Therapeutics Inc's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| Hoth Therapeutics Inc | - | - |
| Vertex Pharmaceuticals Inc | 35.27 | 10.78 |
| Regeneron Pharmaceuticals Inc | 20.00 | 5.65 |
| Alnylam Pharmaceuticals Inc | 7.96 | 4.29 |
| Arrowhead Pharmaceuticals Inc | - | 12.46 |
| Praxis Precision Medicines Inc | - | 945.57 |
| PEERS AVERAGE | 49.90 | 7.75 |
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P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.