Alpine Immune Sciences Inc's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of Alpine Immune Sciences Inc (ALPN) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
Key Findings: Alpine Immune Sciences Inc vs Its Competitors
- TTM: Trailing 12-month revenue of 57M vs 1,331,504M combined for its competitors (0.0% combined share).
- Trending: Latest-quarter revenue run-rate is decelerating (-50.2% annualized vs trailing 12 months), vs decelerating (-29.4%) for its tracked peer group.
- Growth: Alpine Immune Sciences Inc generated -25.1% revenue growth year over year in Q1 2024, vs 28.9% for its competitors combined.
- Profitability: Its -254.8% net margin compares with 3.7% for the peer group.
- Peer revenue share: Alpine Immune Sciences Inc accounted for 0.0% of combined revenue among its tracked peer group, down from 0.0% a year earlier.
- Peer differentiation: Revenue per employee of $2.26M compares with $0.99M for the peer group (2.3x).
Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).
ALPN Sales vs. its Competitors, Q1 2024
Alpine Immune Sciences Inc reported revenue contraction of 25.09 % year on year in Q1 2024, below its competitors' combined revenue growth of 28.94 %.
With a net margin of -254.81 %, Alpine Immune Sciences Inc reported lower profitability than its competitors (3.74 %).
Alpine Immune Sciences Inc generated 0.00 % of the combined sales of its peer group, down from 0.01 % a year earlier.
API endpoints for this dataset
Alpine Immune Sciences Inc vs. its Competitors, Q1 2024
Revenue growth, year on year
Net margin
Revenue run-rate vs trailing 12 months
TTM net margin
TTM = trailing twelve months. Run-rate annualizes the latest quarter (×4) and compares it to TTM. In millions of $. High-Confidence Competitors are named as a competitor directly in Alpine Immune Sciences Inc reports; Similar-Size Competitors are the closest peers by market-cap rank within the same industry; Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC, all independent of the competitor list.
TTM revenue, latest-quarter run-rate and net income/margin benchmarked across Alpine Immune Sciences Inc and its 4 competitor groupings. Available under Commercial License.
| Entity | TTM Revenue | Rev Run-rate vs TTM |
|---|---|---|
| Alpine Immune Sciences Inc | $12,345M | +12.3% · Accelerating |
| Competitors combined | $12,345M | +12.3% · Accelerating |
| Similar Growth & Profitability (6) | $12,345M | +12.3% · Accelerating |
TTM revenue, run-rate and net margin benchmarking across Alpine Immune Sciences Inc's competitor groups requires a Commercial License.
For context: the Major Pharmaceutical Preparations industry grew revenue 8.9% year over year, combined, vs -25.1% for Alpine Immune Sciences Inc. Alpine Immune Sciences Inc's share of combined industry revenue moved from 0.00% to 0.00%, a gain of 0.00 percentage points.
Alpine Immune Sciences Inc's Competitor Quality Breadth
Group definitions: see Methodology: Performance Group Definitions.
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| Alpine Immune Sciences Inc | No | Yes | Yes | No |
| Competitors combined (155) | ||||
| Similar Growth & Profitability (8) | 0.00 % (0 of 8) | 100.00 % (8 of 8) | 100.00 % (8 of 8) | 25.00 % (2 of 8) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
ALPN Stock Performance relative to its Competitors
ALPN Stock Performance relative to Similar Growth & Profitability Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Moderna Inc | 282.9% | Outperformed |
| 2 | Skywater Technology Inc | 282.9% | Outperformed |
| 3 | An2 Therapeutics Inc | 282.9% | Outperformed |
| 4 | Silence Therapeutics Plc | 282.9% | Outperformed |
| 5 | Centessa Pharmaceuticals Plc | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for Alpine Immune Sciences Inc's best-performing competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Alpine Immune Sciences Inc's Comment on Competition and Industry Peers
Publicly Traded Peers of Alpine Immune Sciences Inc
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
 Alpine Immune Sciences Inc |
4,160.23 | 56.52 |
 Taiwan Semiconductor Manufacturing Company Limited |
1,947,076.89 | 121,423.20 |
 Eli Lilly And Company |
1,209,663.60 | 86,462.00 |
 Johnson and Johnson |
676,352.29 | 99,335.00 |
 Beone Medicines Ltd |
612,622.08 | 6,128.24 |
 Asml Holding Nv |
554,085.28 | 36,921.92 |
| SUBTOTAL | 8,942,952.37 | 1,333,021.03 |
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Sources: see Methodology: Peer & Competitor Identification, Sourcing.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Alpine Immune Sciences Inc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
Alpine Immune Sciences Inc's Business Segment Mix vs Peers
Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).| Company | Largest Segment |
|---|---|
| Eli Lilly And Company | Reportable 100.00 % |
| Johnson and Johnson | Oncology 29.93 % |
| Merck and Co Inc | Pharmaceutical segment 89.95 % |
| Applied Materials Inc | Semiconductor Systems 75.41 % |
| Lam Research Corporation | Reportable 100.00 % |
Source: operating segment revenue as reported in each company's reports (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).
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Alpine Immune Sciences Inc's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| Alpine Immune Sciences Inc | 4,160 | 2,260,840 | -1,473,440 |
| Taiwan Semiconductor Manufacturing Company Limited | 1,947,077 | 1,713,299 | 762,463 |
| Eli Lilly And Company | 1,209,664 | 1,729,240 | 551,594 |
| Johnson and Johnson | 676,352 | 705,504 | 114,311 |
| Beone Medicines Ltd | 612,622 | 510,686 | 54,642 |
| Asml Holding Nv | 554,085 | 835,168 | 245,755 |
| PEERS TOTAL | 8,938,792 | 987,420 | 154,928 |
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Alpine Immune Sciences Inc's Geographic Revenue Exposure vs Peers
Revenue by country/region as reported in each company's most recent report. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.| Company | Largest Market |
|---|---|
| Eli Lilly And Company | United States 62.04 % |
| Johnson and Johnson | United States 58.90 % |
| Beone Medicines Ltd | United States 54.39 % |
| Asml Holding Nv | Rest of Europe and Middle East 1.43 % |
| Merck and Co Inc | EMEA 21.50 % |
Source: revenue geography as reported in each company's reports (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.
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Alpine Immune Sciences Inc's Profitability & Cost Structure
Trailing 12-month margins from SEC-filed financials. Operating margin is compared to the Major Pharmaceutical Preparations industry median; gross margin, EBITDA margin and capital intensity are compared to the live industry average (444 companies). See the full Major Pharmaceutical Preparations industry profitability benchmarks.| Metric | Company | Industry | Difference |
|---|---|---|---|
| Gross Margin | 0.00 % | 37.89 % (avg) | -37.9 pp |
| Operating Margin | -90.86 % | industry median | -13.1 pp |
| EBITDA Margin | -67.64 % | -6.23 % (avg) | -61.4 pp |
| Capital Intensity (Capex / Revenue) | 0.73 % | 7.58 % (avg) | -6.8 pp |
Source: CSIMarket API, trailing 12 months. SG&A and R&D as a share of revenue have limited coverage as this data is backfilled and appear only where reported. Higher capital intensity is not inherently negative; it reflects the industry's asset requirements.
Alpine Immune Sciences Inc's Valuation vs Competitive Position
Valuation multiples vs the Major Pharmaceutical Preparations industry average (444 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns. See the full Major Pharmaceutical Preparations industry valuation benchmarks.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 26.6x | - |
| EV / EBITDA | - | 15.9x | - |
| P/B | 7.6x | 4.3x | +3.3x |
| Return on Equity | -14.86 % | industry aggregate | -24.55 % |
| Return on Invested Capital | -9.98 % | -9.83 % (avg) | -0.15 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
Alpine Immune Sciences Inc's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in company reports.| Metric | 2017 | 2019 | 2020 | 2021 | 2022 | 2023 |
|---|---|---|---|---|---|---|
| Revenue Growth | - | - | - | 150.83 % | 28.24 % | 95.84 % |
| Operating Margin | - | - | -307.97 % | - | - | -75.16 % |
| Return on Invested Capital | -9.71 % | -46.04 % | -22.50 % | -22.59 % | -17.26 % | -10.06 % |
| P/E | - | - | - | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
Alpine Immune Sciences Inc's Strategic Group Map
Alpine Immune Sciences Inc is shown in red; its closest peers by combined growth, margin and ROIC are labeled. See Methodology: Strategic Group Map for how this chart is built.
Alpine Immune Sciences Inc's trailing-12-month revenue growth of 118.9% and operating margin of -90.9% compares with an average of 83.4% growth and -52.8% margin across its 8 closest peers by combined growth, margin and ROIC -- Alpine Immune Sciences Inc sits above that peer average on growth and below it on margin.
Source: CSIMarket API, trailing 12 months. Extreme outlier values (from near-zero-revenue companies) are excluded from the plotted cloud but never from the highlighted company or its labeled peers.
Alpine Immune Sciences Inc's Competitive Forces (Porter's Five Forces)
Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.| Force | Assessment | Basis |
|---|---|---|
| Barriers to Entry | Lower than typical for the industry | Capital intensity (capex / revenue) of 0.73 % vs industry average 7.58 % (see Profitability & Cost Structure above) |
Note: see Methodology: Porter's Five Forces. Supplier power and buyer power are covered on Alpine Immune Sciences Inc's dedicated Suppliers and Customers pages, not here.
Alpine Immune Sciences Inc's Industry Attractiveness & Competitive Strength
See Methodology: GE/McKinsey Matrix for how the two axes are built.
Alpine Immune Sciences Inc falls in the Low attractiveness / Medium strength cell: Harvest.
Source: CSIMarket API, trailing 12 months. Each axis score is a simple 1(low)/2(medium)/3(high) average across its three inputs -- a transparent, disclosed simplification, not a validated academic scoring model.
Alpine Immune Sciences Inc's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
No rule matched.
Weaknesses
- Operating margin 13.1 points below the industry median.
- Return on equity 24.6 points below the industry aggregate.
- Latest-quarter revenue run-rate is decelerating (-50.2% annualized vs trailing 12 months).
Opportunities
- A meaningful share of competitors (48.10 %) show financial-distress signals, a possible opening to gain share.
Threats
- Tracked peer group's revenue run-rate is broadly decelerating (-29.4% annualized).
Methodology: see Methodology: SWOT Analysis.
Alpine Immune Sciences Inc's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| Alpine Immune Sciences Inc | 0.72 | 5.81 | - |
| Taiwan Semiconductor Manufacturing Company Limited | 1.82 | 2.51 | 0.02 |
| Eli Lilly And Company | 0.16 | 1.44 | 1.44 |
| Johnson and Johnson | 0.36 | 1.04 | 0.60 |
| Beone Medicines Ltd | 2.30 | 3.16 | 0.23 |
| Asml Holding Nv | 0.53 | 1.26 | 0.19 |
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Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
Alpine Immune Sciences Inc's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| Alpine Immune Sciences Inc | Q1 2024 | -25.1 % | - |
| Taiwan Semiconductor Manufacturing Company Limited | Q4 2025 | +37.6 % | +53.1 % |
| Eli Lilly And Company | Q3 2026 | +38.6 % | +15.6 % |
| Johnson and Johnson | Q3 2026 | +5.9 % | -95.9 % |
| Beone Medicines Ltd | Q2 2026 | +29.7 % | +151.3 % |
| Asml Holding Nv | Q4 2025 | +20.7 % | +32.6 % |
| PEERS TOTAL | +15.2 % | +28.8 % |
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Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
Alpine Immune Sciences Inc's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| Alpine Immune Sciences Inc | Q1 2024 | - | -79.6 % |
| Taiwan Semiconductor Manufacturing Company Limited | Q4 2025 | +25.7 % | +39.1 % |
| Eli Lilly And Company | Q3 2026 | +30.7 % | +52.2 % |
| Johnson and Johnson | Q3 2026 | +10.9 % | +17.7 % |
| Beone Medicines Ltd | Q2 2026 | +6.4 % | -57.0 % |
| Asml Holding Nv | Q4 2025 | +16.9 % | -18.2 % |
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Alpine Immune Sciences Inc's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| Alpine Immune Sciences Inc | - | - | - |
| Taiwan Semiconductor Manufacturing Company Limited | 21.37% | 26.29% | 31.41% |
| Eli Lilly And Company | 21.24% | 32.00% | 83.65% |
| Johnson and Johnson | 8.06% | 10.53% | 19.55% |
| Beone Medicines Ltd | 7.82% | 10.32% | 14.24% |
| Asml Holding Nv | 18.31% | 35.02% | 47.20% |
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ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
Alpine Immune Sciences Inc's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| Alpine Immune Sciences Inc | - | 73.60 |
| Taiwan Semiconductor Manufacturing Company Limited | 70.18 | 16.04 |
| Eli Lilly And Company | 43.96 | 13.99 |
| Johnson and Johnson | 41.79 | 6.81 |
| Beone Medicines Ltd | 924.91 | 99.97 |
| Asml Holding Nv | 57.66 | 15.01 |
| PEERS AVERAGE | 42.77 | 6.71 |
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P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.