Akebia Therapeutics Inc's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of Akebia Therapeutics Inc (AKBA) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
Key Findings: Akebia Therapeutics Inc vs Its Competitors
- TTM: Trailing 12-month revenue of 219M vs 43,008M combined for its competitors (0.5% combined share).
- Trending: Latest-quarter revenue run-rate is decelerating (-10.3% annualized vs trailing 12 months), vs accelerating (+6.4%) for its tracked peer group.
- Growth: Akebia Therapeutics Inc generated -21.4% revenue growth year over year in Q2 2026, vs 12.0% for its competitors combined.
- Profitability: Its -18.1% net margin compares with 22.8% for the peer group.
- Scale: Akebia Therapeutics Inc ranks #276 of 545 companies by market capitalization in the Major Pharmaceutical Preparations industry, holding 0.0% of industry market cap.
- Peer revenue share: Akebia Therapeutics Inc accounted for 0.4% of combined revenue among its tracked peer group, down from 0.6% a year earlier.
- Peer differentiation: Revenue per employee of $1.13M compares with $4.41M for the peer group (0.3x).
- Structure: Akebia Therapeutics Inc operates in the following segments: Reportable.
Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).
AKBA Sales vs. its Competitors, Q2 2026
Akebia Therapeutics Inc reported revenue contraction of 21.36 % year on year in Q2 2026, below its competitors' combined revenue growth of 11.98 %.
With a net margin of -18.13 %, Akebia Therapeutics Inc reported lower profitability than its competitors (22.77 %).
Akebia Therapeutics Inc generated 0.43 % of the combined sales of its peer group, down from 0.61 % a year earlier.
API endpoints for this dataset
Akebia Therapeutics Inc vs. its Competitors, Q2 2026
Revenue growth, year on year
Net margin
Revenue run-rate vs trailing 12 months
TTM net margin
TTM = trailing twelve months. Run-rate annualizes the latest quarter (×4) and compares it to TTM. In millions of $. High-Confidence Competitors are named as a competitor directly in Akebia Therapeutics Inc reports; Similar-Size Competitors are the closest peers by market-cap rank within the same industry; Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC, all independent of the competitor list.
TTM revenue, latest-quarter run-rate and net income/margin benchmarked across Akebia Therapeutics Inc and its 4 competitor groupings. Available under Commercial License.
| Entity | TTM Revenue | Rev Run-rate vs TTM |
|---|---|---|
| Akebia Therapeutics Inc | $12,345M | +12.3% · Accelerating |
| Competitors combined | $12,345M | +12.3% · Accelerating |
| High-Confidence Competitors (1) | $12,345M | +12.3% · Accelerating |
| Similar-Size Competitors (8) | $12,345M | +12.3% · Accelerating |
| Similar Growth & Profitability (2) | $12,345M | +12.3% · Accelerating |
TTM revenue, run-rate and net margin benchmarking across Akebia Therapeutics Inc's competitor groups requires a Commercial License.
For context: the Major Pharmaceutical Preparations industry grew revenue 8.9% year over year, combined, vs -21.4% for Akebia Therapeutics Inc. Akebia Therapeutics Inc's share of combined industry revenue moved from 0.01% to 0.01%, a gain of 0.00 percentage points.
Akebia Therapeutics Inc's Competitor Quality Breadth
Group definitions: see Methodology: Performance Group Definitions.
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| Akebia Therapeutics Inc | No | Yes | No | No |
| Competitors combined (24) | ||||
| High-Confidence Competitors (1) | - | - | - | |
| Similar-Size Competitors (9) | ||||
| Similar Growth & Profitability (8) | 0.00 % (0 of 7) | 100.00 % (8 of 8) | 0.00 % (0 of 8) | 25.00 % (2 of 8) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
AKBA Stock Performance relative to its Competitors
AKBA Stock Performance relative to High-Confidence Competitors
AKBA Stock Performance relative to Similar-Size Competitors
AKBA Stock Performance relative to Similar Growth & Profitability Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Inmed Pharmaceuticals Inc | 282.9% | Outperformed |
| 2 | Iovance Biotherapeutics inc | 282.9% | Outperformed |
| 3 | Nuvectis Pharma inc | 282.9% | Outperformed |
| 4 | Evoke Pharma Inc | 282.9% | Outperformed |
| 5 | Kezar Life Sciences Inc | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for Akebia Therapeutics Inc's best-performing competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Publicly Traded Peers of Akebia Therapeutics Inc
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
 Akebia Therapeutics Inc |
108.19 | 219.06 |
 Amgen Inc |
250,468.48 | 38,095.00 |
 Gsk Plc |
207,208.61 | 43,093.89 |
 Hutchmed china Limited |
13,233.03 | 548.51 |
 Protagonist Therapeutics inc |
9,375.77 | 281.99 |
 Indivior Pharmaceuticals Inc |
4,426.16 | 1,376.00 |
| SUBTOTAL | 495,086.85 | 86,883.57 |
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Sources: see Methodology: Peer & Competitor Identification, Sourcing.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Akebia Therapeutics Inc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
Akebia Therapeutics Inc's Competitors Named by the Company
Competitive relationships identified from Akebia Therapeutics Inc reports and corroborating sources, each with a basis and confidence.| Competitor | Basis | Confidence |
|---|---|---|
| Q32 Bio Inc | Company report | 85% |
| Averoa SAS | Company report | 85% |
| Japan Tobacco, Inc. | Company report | 85% |
| Torii Pharmaceutical Co., Ltd. | Company report | 85% |
| Kyntra Bio Inc | Company report | 85% |
| Gsk Plc | Company report | 85% |
| Amgen Inc | Company report | 85% |
Company report basis, confidence, active dates and source counts for Akebia Therapeutics Inc's named competitors require a Commercial License.
Methodology: see Methodology: Peer & Competitor Identification, Sourcing.
Akebia Therapeutics Inc's Business Segment Mix vs Peers
Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).| Company | Largest Segment |
|---|---|
| Akebia Therapeutics Inc | Reportable 100.00 % |
| Amgen Inc | Reportable 100.00 % |
| Hutchmed china Limited | Other Ventures segment 47.94 % |
| Protagonist Therapeutics inc | Single reportable segment 100.00 % |
| Indivior Pharmaceuticals Inc | Reportable 100.00 % |
| Acadia Pharmaceuticals Inc | Reportable Segment Aggregation Before Other Operating Segment 100.00 % |
Source: operating segment revenue as reported in each company's reports (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).
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Akebia Therapeutics Inc's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| Akebia Therapeutics Inc | 108 | 1,129,175 | -152,918 |
| Amgen Inc | 250,468 | 2,930,385 | 672,538 |
| Gsk Plc | 207,209 | 169,660,977 | 32,662,867 |
| Hutchmed china Limited | 13,233 | 703,221 | 586,836 |
| Protagonist Therapeutics inc | 9,376 | 2,136,303 | 616,273 |
| Indivior Pharmaceuticals Inc | 4,426 | 1,376,000 | 451,000 |
| PEERS TOTAL | 494,979 | 4,409,286 | 922,169 |
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Akebia Therapeutics Inc's Geographic Revenue Exposure vs Peers
Revenue by country/region as reported in each company's most recent report. Disclosure granularity varies by filer (some report by country, others by broad region) and is shown as disclosed.| Company | Largest Market |
|---|---|
| Hutchmed china Limited | CN 74.28 % |
| Iovance Biotherapeutics inc | US 98.66 % |
| Amphastar Pharmaceuticals Inc | US 91.94 % |
Source: revenue geography as reported in each company's reports (10-K/10-Q), via the CSIMarket API. Percentages are of that company's own total consolidated revenue for its most recent reported period.
Akebia Therapeutics Inc's Position in Industry Market Structure
Market-capitalization share and concentration across all 495 companies in Akebia Therapeutics Inc's industry classification, broader than the peer set above. Market cap in millions of $.Akebia Therapeutics Inc ranks #276 of 495 companies by market capitalization in its industry, holding 0.00 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 875, indicating a unconcentrated market structure (see Methodology: Market Structure & Concentration).
| Rank | Company | Market Cap | Industry Share |
|---|---|---|---|
| 1 | Eli Lilly And Company | 1,210,070 | 20.69 % |
| 2 | Johnson and Johnson | 674,004 | 11.53 % |
| 3 | Beone Medicines Ltd | 612,622 | 10.48 % |
| 4 | Abbvie Inc | 515,910 | 8.82 % |
| 5 | Merck and Co Inc | 1,234 | 5.2% |
| 6 | Novartis Ag | 1,234 | 5.2% |
| 7 | Abbott Laboratories | 1,234 | 5.2% |
| 8 | Novo Nordisk A | 1,234 | 5.2% |
| 9 | Pfizer Inc | 1,234 | 5.2% |
| 10 | Astrazeneca Plc | 1,234 | 5.2% |
| 276 | Akebia Therapeutics Inc | 108 | 0.00 % |
Market cap and industry share for the rest of Akebia Therapeutics Inc's industry peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2026-11-06.
Akebia Therapeutics Inc's Same-Size Peers & Stock Performance
Peers chosen by closeness in market-cap rank within the same industry classification (not the named-competitor list above). Trailing 12-month total return, 3-month price momentum, beta and Sharpe ratio vs the broad U.S. market.| Rank | Company | Market Cap | TTM Return |
|---|---|---|---|
| 271 | Cue Biopharma Inc | 119 | -16.37 % |
| 272 | Adagene Inc | 118 | 38.67 % |
| 273 | Semnur Pharmaceuticals Inc | 115 | -94.44 % |
| 274 | Lexaria Bioscience Corp | 112 | 279.63 % |
| 275 | Anixa Biosciences Inc | 1,234 | 12.3% |
| 276 | Akebia Therapeutics Inc | 108 | -80.54 % |
| 277 | Pyxis Oncology Inc | 1,234 | 12.3% |
| 278 | Satellos Bioscience Inc | 1,234 | 12.3% |
| 279 | Organogenesis Holdings Inc | 1,234 | 12.3% |
| 280 | Tuhura Biosciences Inc | 1,234 | 12.3% |
| 281 | Medicus Pharma Ltd | 1,234 | 12.3% |
Market cap, return, momentum, beta and Sharpe ratio for the rest of Akebia Therapeutics Inc's same-size peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation); returns and risk metrics as of 2026-11-06. Beta and Sharpe ratio are versus the broad U.S. equity market, not this industry.
Akebia Therapeutics Inc's Profitability & Cost Structure
Trailing 12-month margins from SEC-filed financials. Operating margin is compared to the Major Pharmaceutical Preparations industry median; gross margin, EBITDA margin and capital intensity are compared to the live industry average (444 companies). See the full Major Pharmaceutical Preparations industry profitability benchmarks.| Metric | Company | Industry | Difference |
|---|---|---|---|
| Gross Margin | 79.63 % | 37.99 % (avg) | +41.6 pp |
| Operating Margin | -6.90 % | industry median | -6.2 pp |
| EBITDA Margin | 0.20 % | -6.20 % (avg) | +6.4 pp |
| Capital Intensity (Capex / Revenue) | 0.59 % | 7.59 % (avg) | -7.0 pp |
Source: CSIMarket API, trailing 12 months. SG&A and R&D as a share of revenue have limited coverage as this data is backfilled and appear only where reported. Higher capital intensity is not inherently negative; it reflects the industry's asset requirements.
Akebia Therapeutics Inc's Valuation vs Competitive Position
Valuation multiples vs the Major Pharmaceutical Preparations industry average (444 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns. See the full Major Pharmaceutical Preparations industry valuation benchmarks.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 26.6x | - |
| EV / EBITDA | 472.5x | 15.9x | +456.6x |
| P/B | 10.1x | 4.3x | +5.9x |
| Return on Equity | -93.74 % | industry aggregate | -110.09 % |
| Return on Invested Capital | -6.38 % | -9.82 % (avg) | 3.44 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
Akebia Therapeutics Inc's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in company reports.| Metric | 2017 | 2018 | 2019 | 2020 | 2021 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|
| Revenue Growth | - | 16.72 % | 61.26 % | -11.85 % | -27.68 % | -33.46 % | -17.70 % | 47.46 % |
| Operating Margin | -44.90 % | -85.76 % | -85.46 % | -127.47 % | -124.23 % | -24.11 % | -31.51 % | 9.95 % |
| Return on Invested Capital | -32.13 % | -27.00 % | -25.53 % | -42.50 % | -46.71 % | -26.68 % | -46.33 % | 9.23 % |
| P/E | - | - | - | - | - | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
Akebia Therapeutics Inc's Strategic Group Map
Akebia Therapeutics Inc is shown in red; its closest peers by combined growth, margin and ROIC are labeled. See Methodology: Strategic Group Map for how this chart is built.
Akebia Therapeutics Inc's trailing-12-month revenue growth of 7.5% and operating margin of -6.9% compares with an average of 5.1% growth and -7.5% margin across its 8 closest peers by combined growth, margin and ROIC -- Akebia Therapeutics Inc sits above that peer average on growth and above it on margin.
Source: CSIMarket API, trailing 12 months. Extreme outlier values (from near-zero-revenue companies) are excluded from the plotted cloud but never from the highlighted company or its labeled peers.
Akebia Therapeutics Inc's BCG Growth-Share Matrix
See Methodology: BCG Growth-Share Matrix for how relative share and growth are calculated and thresholded.
Akebia Therapeutics Inc falls in the Dog quadrant: relative market share of 0.00x vs its largest competitor, in an industry growing revenue 8.1% (median, trailing 12 months).
Source: CSIMarket API (market-cap share and industry revenue growth). The 10% growth and 1.0x share lines are standard textbook thresholds, not derived from this industry's own distribution.
Akebia Therapeutics Inc's Competitive Forces (Porter's Five Forces)
Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.| Force | Assessment | Basis |
|---|---|---|
| Competitive Rivalry | High | Industry HHI of 875 (see Industry Market Structure & Concentration above) |
| Barriers to Entry | Lower than typical for the industry | Capital intensity (capex / revenue) of 0.59 % vs industry average 7.59 % (see Profitability & Cost Structure above) |
Note: see Methodology: Porter's Five Forces. Supplier power and buyer power are covered on Akebia Therapeutics Inc's dedicated Suppliers and Customers pages, not here.
Akebia Therapeutics Inc's Industry Attractiveness & Competitive Strength
See Methodology: GE/McKinsey Matrix for how the two axes are built.
Akebia Therapeutics Inc falls in the Low attractiveness / Medium strength cell: Harvest.
Source: CSIMarket API, trailing 12 months. Each axis score is a simple 1(low)/2(medium)/3(high) average across its three inputs -- a transparent, disclosed simplification, not a validated academic scoring model.
Akebia Therapeutics Inc's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
No rule matched.
Weaknesses
- Operating margin 6.2 points below the industry median.
- Return on equity 110.1 points below the industry aggregate.
- Latest-quarter revenue run-rate is decelerating (-10.3% annualized vs trailing 12 months).
- Underperforming the U.S.A. 500 over the trailing 12 months.
- Low relative market share vs the industry leader (0.00x).
Opportunities
- A meaningful share of competitors (34.80 %) show financial-distress signals, a possible opening to gain share.
Threats
No rule matched.
Methodology: see Methodology: SWOT Analysis.
Akebia Therapeutics Inc's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| Akebia Therapeutics Inc | 1.06 | 1.56 | 1.73 |
| Amgen Inc | 0.46 | 1.26 | 5.86 |
| Gsk Plc | 0.16 | 0.82 | 0.87 |
| Hutchmed china Limited | 0.23 | 4.96 | 0.10 |
| Protagonist Therapeutics inc | 5.28 | 15.94 | - |
| Indivior Pharmaceuticals Inc | 0.23 | 0.74 | - |
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Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
Akebia Therapeutics Inc's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| Akebia Therapeutics Inc | Q2 2026 | -21.4 % | - |
| Amgen Inc | Q2 2026 | +9.5 % | +65.9 % |
| Gsk Plc | Q4 2025 | +7.5 % | +120.0 % |
| Hutchmed china Limited | Q4 2025 | -13.0 % | +1,099.2 % |
| Protagonist Therapeutics inc | Q2 2026 | +3,749.2 % | - |
| Indivior Pharmaceuticals Inc | Q3 2026 | +13.7 % | +226.2 % |
| PEERS TOTAL | +8.1 % | +119.9 % |
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Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
Akebia Therapeutics Inc's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| Akebia Therapeutics Inc | Q2 2026 | +5.1 % | +756.3 % |
| Amgen Inc | Q2 2026 | -6.6 % | +39.0 % |
| Gsk Plc | Q4 2025 | +7.2 % | -0.6 % |
| Hutchmed china Limited | Q4 2025 | -3.6 % | -44.2 % |
| Protagonist Therapeutics inc | Q2 2026 | - | -79.3 % |
| Indivior Pharmaceuticals Inc | Q3 2026 | -38.6 % | -30.0 % |
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Akebia Therapeutics Inc's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| Akebia Therapeutics Inc | - | - | - |
| Amgen Inc | 9.48% | 13.08% | 89.32% |
| Gsk Plc | 10.09% | 44.94% | 38.67% |
| Hutchmed china Limited | 26.11% | 30.87% | 36.98% |
| Protagonist Therapeutics inc | 11.02% | 11.66% | 11.80% |
| Indivior Pharmaceuticals Inc | 36.35% | 108.22% | - |
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ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
Akebia Therapeutics Inc's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| Akebia Therapeutics Inc | - | 0.49 |
| Amgen Inc | 28.60 | 6.57 |
| Gsk Plc | 36.26 | 4.81 |
| Hutchmed china Limited | 29.15 | 24.13 |
| Protagonist Therapeutics inc | 129.45 | 33.25 |
| Indivior Pharmaceuticals Inc | 8.48 | 3.22 |
| PEERS AVERAGE | 27.36 | 5.70 |
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P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.