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The competitive landscape for OLINVYK includes products in mid- and late-stage clinical development targeting the treatment of moderate-to-severe acute pain. Avenue Therapeutics, Inc. is developing an intravenous version of the generic opioid tramadol for this indication. The company competes with major pharmaceutical, specialty pharmaceutical, and biotechnology firms, as well as academic institutions, governmental agencies, and public and private research organizations. Competitors may possess greater financial resources and expertise in research and development, manufacturing, clinical trials, regulatory approvals, and marketing. Industry mergers and acquisitions may further concentrate resources among fewer competitors. Additionally, smaller or early-stage companies may also present significant competition.