Aytu Biopharma Inc's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of Aytu Biopharma Inc (AYTU) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
Key Findings: Aytu Biopharma Inc vs Its Competitors
- TTM: Trailing 12-month revenue of 56M vs 513M combined for tracked competitors (9.8% combined share).
- Trending: Latest-quarter revenue run-rate is accelerating (+16.0% annualized vs trailing 12 months), vs accelerating (+2.6%) for its tracked peer group.
- Growth: Aytu Biopharma Inc generated -0.9% revenue growth year over year in Q4 2026, vs -8.1% for its tracked competitors combined.
- Profitability: Its -0.1% net margin compares with -106.6% for the peer group.
- Scale: Aytu Biopharma Inc ranks #367 of 544 companies by market capitalization in the Major Pharmaceutical Preparations industry, holding 0.0% of industry market cap.
- Peer revenue share: Aytu Biopharma Inc accounted for 10.9% of combined revenue among its tracked peer group, up from 10.2% a year earlier.
- Peer differentiation: Revenue per employee of $0.73M compares with $0.27M for the peer group (2.7x).
Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).
AYTU Sales vs. its Competitors, Q4 2026
Aytu Biopharma Inc reported revenue contraction of 0.91 % year on year in Q4 2026, above its competitors' combined revenue change of -8.12 %.
With a net margin of -0.09 %, Aytu Biopharma Inc achieved higher profitability than its competitors (-106.63 %).
Aytu Biopharma Inc generated 10.89 % of the combined sales of its peer group, up from 10.18 % a year earlier.
Aytu Biopharma Inc vs. its Competitors, Q4 2026
Revenue growth, year on year
Net margin
Revenue run-rate vs trailing 12 months
TTM net margin
TTM = trailing twelve months. Run-rate annualizes the latest quarter (×4) and compares it to TTM. In millions of $. High-Confidence Competitors are named as a competitor directly in an SEC filing; Similar-Size Competitors are the closest peers by market-cap rank within the same industry; Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC, all independent of the competitor list.
TTM revenue, latest-quarter run-rate and net income/margin benchmarked across Aytu Biopharma Inc and its 4 competitor groupings. Available under Commercial License.
| Entity | TTM Revenue | Rev Run-rate vs TTM |
|---|---|---|
| Aytu Biopharma Inc | $12,345M | +12.3% · Accelerating |
| Competitors combined | $12,345M | +12.3% · Accelerating |
| Similar-Size Competitors (7) | $12,345M | +12.3% · Accelerating |
| Similar Growth & Profitability (6) | $12,345M | +12.3% · Accelerating |
TTM revenue, run-rate and net margin benchmarking across Aytu Biopharma Inc's competitor groups requires a Commercial License.
For context: the Major Pharmaceutical Preparations industry grew revenue 7.2% year over year, combined, vs -0.9% for Aytu Biopharma Inc. Aytu Biopharma Inc's share of combined industry revenue moved from 0.00% to 0.00%, a gain of 0.00 percentage points.
Aytu Biopharma Inc's Competitor Quality Breadth
Share of each group, trailing 12 months: profitable (net margin > 0), expanding (revenue growth > 0), growing faster than the industry's own median, and financially distressed (Piotroski F-Score of 2 or below).
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| Aytu Biopharma Inc | No | No | No | Yes |
| Competitors combined (11) | ||||
| High-Confidence Competitors (1) | ||||
| Similar-Size Competitors (9) | ||||
| Similar Growth & Profitability (8) | 0.00 % (0 of 8) | 0.00 % (0 of 8) | 0.00 % (0 of 8) | 50.00 % (4 of 8) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
AYTU Stock Performance relative to its Competitors
AYTU Stock Performance relative to High-Confidence Competitors
AYTU Stock Performance relative to Similar-Size Competitors
AYTU Stock Performance relative to Similar Growth & Profitability Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Zevra Therapeutics Inc | 282.9% | Outperformed |
| 2 | Lifecore Biomedical Inc | 282.9% | Outperformed |
| 3 | Amarin Corp Plcuk | 282.9% | Outperformed |
| 4 | Evofem Biosciences Inc | 282.9% | Outperformed |
| 5 | Tonix Pharmaceuticals Holding Corp | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for Aytu Biopharma Inc's best-performing tracked competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Aytu Biopharma Inc's Comment on Competition and Industry Peers
Publicly Traded Peers of Aytu Biopharma Inc
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
| Aytu Biopharma Inc | 26.73 | 55.52 |
| Biodexa Pharmaceuticals Plc | 7,456.72 | 0.38 |
| Amarin Corp Plcuk | 5,517.88 | 186.48 |
| Zevra Therapeutics Inc | 693.10 | 128.86 |
| Lifecore Biomedical Inc | 244.35 | 125.08 |
| Tonix Pharmaceuticals Holding Corp | 164.69 | 29.10 |
| SUBTOTAL | 14,273.27 | 694.47 |
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Sources: Aytu Biopharma Inc's official press releases and regulatory filings; CSIMarket.com's market research; and the financial filings and press releases of the other companies cited.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Aytu Biopharma Inc versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
Aytu Biopharma Inc's Competitors Named by the Company
Competitive relationships identified from SEC filings and corroborating sources, each with a basis and confidence.| Competitor | Basis | Confidence |
|---|---|---|
| Novartis | Named by the company | 85% |
| Amman Pharmaceutical Industries | Named by the company | 85% |
| Takada Pharmaceutical Company | Named by the company | 85% |
| Janssen | Named by the company | 85% |
| Zevra Therapeutics Inc | Named by the company | 85% |
Filing basis, confidence, active dates and source counts for Aytu Biopharma Inc's named competitors require a Commercial License.
Methodology: relationships are extracted from SEC filings (named-competitor disclosures) and corroborating sources. Named by the company = explicitly disclosed as a competitor; Inferred = derived from corroborating signals. Confidence reflects evidence strength.
Aytu Biopharma Inc's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| Aytu Biopharma Inc | 27 | 730,461 | -187,526 |
| Biodexa Pharmaceuticals Plc | 7,457 | 34,636 | -580,364 |
| Amarin Corp Plcuk | 5,518 | 113,018 | -16,439 |
| Zevra Therapeutics Inc | 693 | 2,112,377 | 949,246 |
| Lifecore Biomedical Inc | 244 | 598,469 | -220,029 |
| Tonix Pharmaceuticals Holding Corp | 165 | 204,944 | -1,124,408 |
| PEERS TOTAL | 14,247 | 270,972 | -186,038 |
Aytu Biopharma Inc's Position in Industry Market Structure
Market-capitalization share and concentration across all 498 companies in Aytu Biopharma Inc's industry classification, broader than the peer set above. Market cap in millions of $.Aytu Biopharma Inc ranks #367 of 498 companies by market capitalization in its industry, holding 0.00 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 827, indicating a unconcentrated market structure (U.S. antitrust guidance: below 1,500 unconcentrated, 1,500 to 2,500 moderately concentrated, above 2,500 highly concentrated).
| Rank | Company | Market Cap | Industry Share |
|---|---|---|---|
| 1 | Eli Lilly And Company | 1,062,533 | 19.39 % |
| 2 | Johnson and Johnson | 664,610 | 12.13 % |
| 3 | Beone Medicines Ltd | 545,679 | 9.96 % |
| 4 | Abbvie Inc | 467,633 | 8.54 % |
| 5 | Merck and Co Inc | 1,234 | 5.2% |
| 6 | Novartis Ag | 1,234 | 5.2% |
| 7 | Abbott Laboratories | 1,234 | 5.2% |
| 8 | Novo Nordisk A | 1,234 | 5.2% |
| 9 | Pfizer Inc | 1,234 | 5.2% |
| 10 | Vertex Pharmaceuticals Inc | 1,234 | 5.2% |
| 367 | Aytu Biopharma Inc | 27 | 0.00 % |
Market cap and industry share for the rest of Aytu Biopharma Inc's industry peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2026-09-28.
Aytu Biopharma Inc's Same-Size Peers & Stock Performance
Peers chosen by closeness in market-cap rank within the same industry classification (not the named-competitor list above). Trailing 12-month total return, 3-month price momentum, beta and Sharpe ratio vs the broad U.S. market.| Rank | Company | Market Cap | TTM Return |
|---|---|---|---|
| 362 | Igc Pharma Inc | 29 | -24.62 % |
| 363 | China Pharma Holdings Inc | 29 | -62.82 % |
| 364 | Abvc Biopharma Inc | 29 | -64.78 % |
| 365 | Nasus Pharma Ltd | 28 | -56.15 % |
| 366 | Kyntra Bio Inc | 1,234 | 12.3% |
| 367 | Aytu Biopharma Inc | 27 | 19.21 % |
| 368 | Bioharvest Sciences Inc | 1,234 | 12.3% |
| 369 | Nextcure Inc | 1,234 | 12.3% |
| 370 | Therapeuticsmd Inc | 1,234 | 12.3% |
| 371 | Provectus Biopharmaceuticals Inc | 1,234 | 12.3% |
| 372 | Gridai Technologies Corp | 1,234 | 12.3% |
Market cap, return, momentum, beta and Sharpe ratio for the rest of Aytu Biopharma Inc's same-size peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation); returns and risk metrics as of 2026-09-28. Beta and Sharpe ratio are versus the broad U.S. equity market, not this industry.
Aytu Biopharma Inc's Profitability & Cost Structure
Trailing 12-month margins from SEC-filed financials. Operating margin is compared to the Major Pharmaceutical Preparations industry median; gross margin, EBITDA margin and capital intensity are compared to the live industry average (341 companies).| Metric | Company | Industry | Difference |
|---|---|---|---|
| Gross Margin | 66.32 % | 64.89 % (avg) | +1.4 pp |
| Operating Margin | -14.98 % | industry median | +38.7 pp |
| EBITDA Margin | -5.04 % | -7.21 % (avg) | +2.2 pp |
| Capital Intensity (Capex / Revenue) | - | 4.92 % (avg) | - |
Source: CSIMarket API, trailing 12 months. SG&A and R&D as a share of revenue have limited coverage as this data is backfilled and appear only where reported. Higher capital intensity is not inherently negative; it reflects the industry's asset requirements.
Aytu Biopharma Inc's Valuation vs Competitive Position
Valuation multiples vs the Major Pharmaceutical Preparations industry average (341 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 25.1x | - |
| EV / EBITDA | - | 17.3x | - |
| P/B | 1.0x | 4.5x | -3.4x |
| Return on Equity | -50.65 % | industry aggregate | -67.90 % |
| Return on Invested Capital | -10.19 % | -2.95 % (avg) | -7.24 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
Aytu Biopharma Inc's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in SEC filings.| Metric | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|
| Revenue Growth | 22.46 % | 82.98 % | 493.49 % | 58.63 % | 28.78 % | -8.43 % | -29.29 % | -9.51 % |
| Operating Margin | -405.90 % | -213.37 % | -39.78 % | -108.23 % | -76.73 % | -8.03 % | -11.51 % | -14.02 % |
| Return on Invested Capital | -53.28 % | -39.29 % | -9.16 % | -32.20 % | -63.03 % | -7.71 % | -10.27 % | -11.16 % |
| P/E | - | - | - | - | - | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
Aytu Biopharma Inc's Strategic Group Map
Every company in Aytu Biopharma Inc's industry and named-competitor list, plotted by trailing 12-month revenue growth and operating margin. Aytu Biopharma Inc is shown in red; its closest peers by combined growth, margin and ROIC (the Similar Growth & Profitability group above) are labeled.
Source: CSIMarket API, trailing 12 months. Extreme outlier values (from near-zero-revenue companies) are excluded from the plotted cloud but never from the highlighted company or its labeled peers.
Aytu Biopharma Inc's BCG Growth-Share Matrix
Relative market share (vs Aytu Biopharma Inc's largest competitor by market cap) against industry revenue growth, using the standard textbook thresholds (1.0x share, 10% growth) a common framework, not a precision instrument.
Aytu Biopharma Inc falls in the Dog quadrant: relative market share of 0.00x vs its largest competitor, in an industry growing revenue 8.0% (median, trailing 12 months).
Source: CSIMarket API (market-cap share and industry revenue growth). The 10% growth and 1.0x share lines are standard textbook thresholds, not derived from this industry's own distribution.
Aytu Biopharma Inc's Competitive Forces (Porter's Five Forces)
Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.| Force | Assessment | Basis |
|---|---|---|
| Competitive Rivalry | High | Industry HHI of 827 (see Industry Market Structure & Concentration above) |
| Supplier Power | Not covered on this page | See Aytu Biopharma Inc's dedicated suppliers page for concentration and dependency data |
| Buyer Power | Not covered on this page | See Aytu Biopharma Inc's dedicated customers page for concentration and dependency data |
| Threat of Substitutes | - | No systematic data source for cross-product substitution exists in this system; not estimated |
Note: this is a partial, data-grounded application of the framework, not a complete strategic assessment. Rivalry and barriers-to-entry readings are mechanical translations of the HHI and capital-intensity figures shown elsewhere on this page, not independent judgments.
Aytu Biopharma Inc's Industry Attractiveness & Competitive Strength
A CSIMarket composite, not a standard field: each axis is an equal-weighted average of three factors already shown elsewhere on this page (industry growth, industry profitability and rivalry for attractiveness; relative market share, profitability and growth vs industry for strength). Disclosed as a designed methodology, not a precision measurement.
Aytu Biopharma Inc falls in the Low attractiveness / Low strength cell: Harvest / Divest.
Source: CSIMarket API, trailing 12 months. Each axis score is a simple 1(low)/2(medium)/3(high) average across its three inputs -- a transparent, disclosed simplification, not a validated academic scoring model.
Aytu Biopharma Inc's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
- Operating margin 38.7 points above the industry median.
- Latest-quarter revenue run-rate is accelerating (+16.0% annualized vs trailing 12 months).
- Outperforming the U.S.A. 500 over the trailing 12 months.
Weaknesses
- Return on equity 67.9 points below the industry aggregate.
- Low relative market share vs the industry leader (0.00x).
- Piotroski F-Score of 2 or below, the standard financial-distress signal.
Opportunities
- A meaningful share of tracked competitors (36.40 %) show financial-distress signals, a possible opening to gain share.
Threats
No rule matched.
Methodology: mechanical, rule-based SWOT. Each bullet reuses a figure already sourced and cited elsewhere on this page; nothing here is generated narrative or independent analyst judgment.
Aytu Biopharma Inc's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| Aytu Biopharma Inc | 0.48 | 1.19 | 0.52 |
| Biodexa Pharmaceuticals Plc | 1.39 | 2.03 | - |
| Amarin Corp Plcuk | 0.74 | 3.48 | - |
| Zevra Therapeutics Inc | 2.22 | 5.77 | 0.17 |
| Lifecore Biomedical Inc | 0.48 | 2.97 | - |
| Tonix Pharmaceuticals Holding Corp | 6.76 | 7.55 | - |
Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
Aytu Biopharma Inc's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| Aytu Biopharma Inc | Q2 2026 | -0.9 % | - |
| Biodexa Pharmaceuticals Plc | Q4 2025 | - | - |
| Amarin Corp Plcuk | Q2 2026 | -41.6 % | - |
| Zevra Therapeutics Inc | Q2 2026 | +53.3 % | -88.8 % |
| Lifecore Biomedical Inc | Q1 2026 | -30.0 % | - |
| Tonix Pharmaceuticals Holding Corp | Q2 2026 | +577.9 % | - |
| PEERS TOTAL | -11.2 % | - |
Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
Aytu Biopharma Inc's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| Aytu Biopharma Inc | Q2 2026 | -5.0 % | -99.6 % |
| Biodexa Pharmaceuticals Plc | Q4 2025 | - | -77.1 % |
| Amarin Corp Plcuk | Q2 2026 | +22.8 % | - |
| Zevra Therapeutics Inc | Q2 2026 | -87.7 % | +1.9 % |
| Lifecore Biomedical Inc | Q1 2026 | -14.3 % | - |
| Tonix Pharmaceuticals Holding Corp | Q2 2026 | -78.5 % | +11.4 % |
Aytu Biopharma Inc's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| Aytu Biopharma Inc | - | - | - |
| Biodexa Pharmaceuticals Plc | - | - | - |
| Amarin Corp Plcuk | - | - | - |
| Zevra Therapeutics Inc | 20.39% | 22.90% | 32.56% |
| Lifecore Biomedical Inc | - | - | - |
| Tonix Pharmaceuticals Holding Corp | - | - | - |
ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
Aytu Biopharma Inc's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| Aytu Biopharma Inc | - | 0.48 |
| Biodexa Pharmaceuticals Plc | - | 19,571.43 |
| Amarin Corp Plcuk | - | 29.59 |
| Zevra Therapeutics Inc | 12.02 | 5.38 |
| Lifecore Biomedical Inc | - | 1.95 |
| Tonix Pharmaceuticals Holding Corp | - | 5.66 |
| PEERS AVERAGE | - | 20.55 |
P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.