Pfizer Inc (PFE) Return on Investment ROI from the second quarter of 2026 to second quarter of 2025 and for the year 2026, average high and low, overall ranking from Jun 28 2026 to Jun 29 2025 - CSIMarket
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Pfizer Inc  (NYSE: PFE)


Pfizer Inc's ROI from its second quarter of 2026 to the second quarter of 2025 and 5 Year Period

Return on Investment, Quarterly Results, Trends, Rankings, Statistics

What is Pfizer Inc's ROI in the second quarter of 2026?
Pfizer Inc achieved a return on average invested assets (ROI) of 2.57 % in its second quarter of 2026, which is below Pfizer Inc's average return on investment, which stands at 9.41%.

ROI decreased relative to the period ending Mar 29 2026, due to the decline in net income.

Within the Healthcare sector 88 other companies had a higher return on investment. While Return on investment, overall ranking has progressed in the Jun 28 2026 quarter, so far to 1627, from total ROI ranking in the first quarter of 2026 at 1633.

Definition and Formula of Return on Investment



Return On Investment (Jun 28 2026)
II. Quarter
(Mar 29 2026)
I. Quarter
(Dec 31 2025)
IV. Quarter
(Sep 28 2025)
III. Quarter
(Jun 29 2025)
II. Quarter
Y / Y Investment Change TTM 0.38 % -0.94 % -2.76 % -4.6 % -5.29 %
Y / Y Net Income Change TTM -59.51 % -4.76 % 58.17 % 118.29 % 22383.33 %
Investment (TTM) in Millions 168,787 171,161 171,475 169,963 166,205
Return On Investment (TTM) 2.57 % 4.44 % 4.61 % 5.85 % 6.36 %
PFE's Overall Ranking # 1627 # 1633 # 1272 # 1156 # 1016
Seq. Investment Change TTM 0.38 % 0.23 % 0.43 % -0.65 % -0.94 %
Seq. Net Income Change TTM -42 % -3.55 % -20.84 % -8.55 % 36.4 %
Net Income (TTM) in Millions 4,370 7,535 7,812 9,869 10,792




Return On Investment PFE's Ranking
Within: No.
Industry # 24
Sector # 89
Overall # 1627

Return On Investment Statistics
High Average Low
20.85 %
9.41 %
-1.42 %
(Dec 31 2022)   (Jun 30 2024)



  News about Pfizer Inc Return on Investment ROI

A New Chapter in Hemophilia Treatment Pfizer’s HYMPAVZI Approval and Its Implications for the Pharmaceutical Landscape

October 14, 2024

In a significant breakthrough for hemophilia treatment and patient care, Pfizer Inc. has received approval from the U.S. Food and Drug Administration (FDA) for its innovative drug, HYMPAVZI (marstacimab-hncq). This approval marks a pivotal moment not only for the company but also for the broader healthcare landscape dealing with hemophilia A and B, genetic disorders characterized by the insufficient production of clotting factors, leading to prolonged bleeding episodes. Hympavzi: A Breakdown of the ApprovalHYMPAVZI is the first treatment specifically indicated for routine prophylaxis to prevent or reduce bleeding episodes in adults and adolescent patients aged 12 years and older who are living with hemophilia A without factor VIII inhibitors, or hemophilia B without factor IX inhibitors. The nature of hemophilia treatment has traditionally revolved around factor replacement therapies, which, while effective, often come with limitations such as development of inhibitors that can complicate the treatment process. With the FDA’s endorsement, HYMPAVZI introduces a new frontier a targeted therapy that emphasizes both safety and patient-centered outcomes.

Pfizer Pioneers Hope Promising Phase 2 Data for Ponsegromab Offers New Hope for Cancer Cachexia Patients

September 16, 2024

Pfizer Pioneers Hope: Promising Phase 2 Data for Ponsegromab Offers New Hope for Cancer Cachexia Patients In an exciting development for patients battling the dual challenges of cancer and cachexia, Pfizer Inc. (NYSE: PFE) has announced encouraging results from its Phase 2 study of ponsegromab, a monoclonal antibody designed to target growth differentiation factor-15 (GDF-15). This condition, known as cancer cachexia, leads to severe weight loss and muscle wasting, amplifying the hardships faced by cancer patients and impacting their overall quality of life. The study has successfully met its primary endpoint, demonstrating a statistically significant change in body weight from baseline in patients treated with ponsegromab compared to those receiving a placebo. For individuals grappling with elevated levels of GDF-15, this could represent a transformative step in addressing a commonly overlooked yet debilitating aspect of cancer care.Cachexia affects up to 80% of patients with advanced cancer and contributes to both morbidity and mortality. As traditional cancer treatments focus more on tumor reduction, the management of cachexia is often sidelined. Pfizer s intervention, targeting a biological pathway associated with muscle wasting, could provide a new avenue for improving patient outcomes.

Pfizer Inc. (NYSE PFE), renowned for its integral role in advancing medical science, has recent...

September 14, 2024

Breakthroughs in Pharmaceutical Advances: Pfizer s Latest Developments in Oncology, Digital Healthcare Access, and Immunization Pfizer Inc. (NYSE: PFE), renowned for its integral role in advancing medical science, has recently announced significant progress in several facets of healthcare. The company s groundbreaking developments span oncology, digital healthcare access, and immunization, marking pivotal advancements that promise to impact millions of lives. This article delves into the extended clinical data on BRAFTOVI (encorafenib) + MEKTOVI (binimetinib) for BRAF V600E-mutant metastatic non-small cell lung cancer (NSCLC), the launch of the PfizerForAll digital platform, and the promising results from the Phase 3 trial of ABRYSVO, a vaccine for RSV in immunocompromised adults. BRAFTOVI + MEKTOVI Shows Long-Term Efficacy in BRAF V600E-Mutant NSCLC Recent data from the Phase 2 single-arm PHAROS clinical trial have underlined the efficacy and safety of BRAFTOVI (encorafenib) in combination with MEKTOVI (binimetinib) in patients with BRAF V600E-mutant metastatic non-small cell lung cancer (NSCLC). The extended follow-up of 18 months has yielded promising results.

Pfizer and BioNTech Advance mRNA Vaccine Armament Against Influenza and COVID-19; Company Reports Decline in Fiscal P...

August 16, 2024

In the bustling realms of New York and Mainz, Germany, on the Sixteenth Day of August in the Year of Our Lord 2024, an announcement of considerable significance was made by the esteemed pharmaceutical entities, Pfizer Inc., and BioNTech SE. These illustrious companies have provided an update concerning their collaborative endeavors in the development of a novel mRNA-based combination vaccine, targeting the dual threats of Influenza and the COVID-19 virus, specifically amongst healthy individuals aged eighteen to sixty-four years.This joint undertaking has yielded promising top-line results from the Phase 3 clinical trial, wherein the efficacy of the combined vaccine candidate, comprised of Pfizer’s mRNA-based influenza vaccine alongside their licensed COVID-19 vaccine, was diligently scrutinized. The trial evaluated two primary immunogenicity s: to ascertain the immune response against SARS-CoV-2, as well as the stipulated effectiveness against influenza A and B viruses. It is noteworthy that the trial successfully met one of its defined primary s.






Financial Statements
Pfizer Inc's II. Quarter Investments $ 168,787 Millions PFE's Balance sheet
Pfizer Inc's II. Quarter Income $ -237 Millions Quarterly PFE's Income Statement
PFE's Income by Division See PFE's Income by Division


PFE Annual Return On Investment (Dec 31 2025)
2025
(Dec 31 2024)
2024
(Dec 31 2023)
2023
(Dec 31 2022)
2022
(Dec 31 2021)
2021
Total Investments in Millions 171,475 168,573 178,981 155,322 138,717
Y / Y Investment Growth 1.72 % -5.82 % 15.23 % 11.97 % 11.44 %
Net Income in Millions 7,812 8,062 2,158 31,407 22,025
Y / Y Net Income Growth -3.1 % 273.59 % -93.13 % 42.6 % 128.19 %
Annual Return On Investment 4.56 % 4.78 % 1.21 % 20.22 % 15.88 %


Annual Roi Comment
In the fiscal year 2025 ROI decreased relative to the previous year to 4.56 %, due to deterioration of net income.

Definition and Formula of Return on Investment

Other ROI Ratios
Major Pharmaceutical Preparations Industry Roi Trends and Statistics
Healthcare Sector Return On Investment Statistics
Roi Trends for overall market
PFE's Roi Ratio versus Major Pharmaceutical Preparations Industry, Healthcare Sector and total Market
Highest Ranking Return On Investment
Lowest Ranking Return On Investment
Subscribers only: Roi for PFE's Competitors
Subscribers only: Roi for Pfizer Inc's Suppliers
Subscribers only: Return On Investment for PFE's Customers

Other Ratios
PFE's Roa PFE's Inventory Turnover Ratio PFE's Growth Rates PFE's Dividend Statistics
PFE's Profitability Ratios PFE's Asset Turnover Ratio PFE's Dividend Growth
PFE's Roe PFE's Valuation Ratios PFE's Financial Strength Ratios PFE's Dividend Payout Ratio



Companies with similar Return On Investment at Jun 28 2026, within Healthcare Sector ROI
Davita Inc   6.92 %
Kewaunee Scientific Corporation  6.58 %
Medtronic Plc  6.46 %
Siga Technologies Inc  6.45 %
Labcorp Holdings Inc   6.11 %
Royalty Pharma Plc  6.09 %
Pacs Group Inc   5.86 %
Merit Medical Systems Inc  5.80 %
Ensign Group Inc  5.75 %
Nrc Health  5.72 %
IMPACT BIOMEDICAL INC.  5.68 %
Vericel Corporation  5.58 %
Amphastar Pharmaceuticals Inc   5.33 %
Sotera Health Company  5.21 %
The Cooper Companies Inc   5.09 %
Henry Schein Inc   5.06 %
Cadre Holdings inc   4.92 %
Haemonetics Corporation  4.91 %
The Pennant Group Inc   4.62 %
Vaso Corporation  4.40 %
Zimmer Biomet Holdings Inc   3.97 %
U S Physical Therapy Inc  3.91 %
Privia Health Group Inc   3.90 %
Integer Holdings Corporation  3.88 %
Ardent Health Inc   3.74 %
Collegium Pharmaceutical Inc   3.72 %
Merck and Co Inc   3.24 %
Community Health Systems Inc   3.12 %
National Vision Holdings Inc   2.99 %
Teva Pharmaceutical Industries Limited  2.66 %


Date modified: 2026-09-12T06:19:22+00:00



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