Castle Biosciences Inc (CSTL) Quarterly and Annual Segment Results by Country and Region - CSIMarket
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Castle Biosciences Inc   (NASDAQ: CSTL)
    Sector  Healthcare    Industry Medical Laboratories
   Industry Medical Laboratories
   Sector  Healthcare

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Description of Castle Biosciences Inc's Business Segments


Castle Biosciences Inc. is a forward-thinking medical technology company focused on enhancing cancer diagnosis and treatment through precision medicine. Its innovative products and services are designed to deliver accurate diagnostic insights and predictive information, ultimately improving patient outcomes in oncology and dermatology. Below is an extensive overview of the companys segments, products, and services.

Segments
1. Oncology:
Castle Biosciences operates primarily within this segment, focusing on the genomics of various cancers, particularly skin cancers such as melanoma, uveal melanoma, and cutaneous squamous cell carcinoma (cSCC). The genomic tests developed by Castle aim to provide critical prognostic and therapeutic information that supports oncologists in treatment decision-making.

2. Dermatology:
In the dermatology segment, Castle focuses on non-invasive genetic testing for skin lesions that may indicate malignancy. This genre of testing is intended to reduce unnecessary invasive procedures and lead to more precise treatment plans.

Products
1. DecisionDx-UM:
This genomic test is focused on uveal melanoma, a rare yet aggressive form of eye cancer. It evaluates the activity of 15 genes within the tumor tissue, categorizing patients as either high-risk or low-risk. This stratification is crucial for guiding treatment decisions such as the need for adjuvant therapy or more aggressive monitoring.

2. DecisionDx-SCC:
Aimed at cutaneous squamous cell carcinoma, this test assesses the expression of 40 genes in the tumor. The results yield insights into the likelihood of metastasis and recurrence, providing doctors with a clearer picture of a patient’s prognosis and aiding in treatment planning.

3. DecisionDx-Melanoma:
This test is pivotal for patients diagnosed with melanoma, the most aggressive form of skin cancer. It examines 31 genes and assigns risk levels (low-risk or high-risk) for both recurrence and metastasis, enabling tailored follow-up and treatment strategies.

4. DecisionDx-DiffDx Melanoma:
Designed to differentiate between malignant melanoma and benign nevi, this test employs gene expression analysis to enhance diagnostic accuracy. By identifying whether a lesion is likely malignant, it can help reduce the number of unnecessary biopsies and surgeries, which can be burdensome for patients.

5. DecisionDx-UMSeq:
This genomic test provides a detailed analysis of DNA mutations specifically in uveal melanoma. The insights gained from this analysis can inform treatment options, monitoring strategies, and overall patient management.

6. Skin Cancer Genomic Test:
This non-invasive test targets suspicious pigmented skin lesions that may suggest skin cancer. By analyzing 40 genes, it assesses the probability of melanoma versus non-melanoma skin cancers, offering crucial information to dermatologists for early and accurate diagnosis.

Services
1. Biobank Services:
Castle Biosciences provides biobank services aimed at the collection and preservation of patient samples. This facility supports future diagnostic endeavors and research, fostering advancements in genomic testing and cancer care.

2. Data Analytics Services:
The company offers data analytics services that assist healthcare professionals in interpreting genomic test results. These services enhance the clinical utility of the genomic information, ensuring that it informs optimal patient management strategies.

3. Medical Education and Training:
Recognizing the complexities involved in genomic testing, Castle Biosciences provides educational programs aimed at healthcare professionals. These initiatives focus on the application and interpretation of genomic tests, supporting practitioners in integrating these tools into their clinical practice effectively.

4. Patient Advocacy and Support:
Castle Biosciences collaborates with patient advocacy groups to offer essential resources and support structures for patients and their families. This commitment to patient-centered care underscores the companys dedication to improving the cancer journey for those affected.

In conclusion, Castle Biosciences Inc. stands at the forefront of cancer diagnostics and treatment through its extensive offering of genomic tests, all tailored to enhance the accuracy of diagnoses and personalize treatment plans for patients. The company’s commitment to innovative solutions is evidenced not only in its products but also in its supporting services that foster an integrated approach to cancer patient care.


Composition of Castle Biosciences Inc Revenues by Segments

 
Dermatologic    49.12 % of total Revenue
Non-Dermatologic    50.88 % of total Revenue
Reportable Segment    100 % of total Revenue

Q1 three months ended (Mar 31 2026)
Revenues by Business Segments Revenues
(in millions $)
%
(of total Revenues)
Dermatologic 41.11 49.12 %
Non-Dermatologic 42.57 50.88 %
Reportable Segment 83.68 100 %
Total 83.68 100 %




Q1 three months ended (Mar 31 2026)
Revenue Growth rates by Segment Y/Y Revenue
%
Q/Q Revenue
%
Dermatologic -34.71 % -
Non-Dermatologic 70.12 % -
Reportable Segment -4.9 % -
Total -4.9 % -75.69 %




Q1 three months ended (Mar 31 2026)
Income by Business Segments Income
(in millions $)
%
(Profit Margin)
Reportable Segment -14.52 -
Total -0.11 -




Q1 three months ended (Mar 31 2026)
Income Growth rates by Segment Y/Y Income
%
Q/Q Income
%
Reportable Segment - -
Total - -




Annual Report on Castle Biosciences Inc Divisions, Sales by Country

 
Dermatologic   Dermatologic Segment contribution to total sales 62.86 % of total Revenue
Reportable Segment   Reportable Segment Segment contribution to total sales 100 % of total Revenue
Non Dermatologic   Non Dermatologic Segment contribution to total sales 37.14 % of total Revenue


Twelve months ended 2025
CSTL s Annual Revenue by Geography and Business Segments Sales
(in millions $)
%
(of total Sales)
Dermatologic 216.37 62.86 %
Reportable Segment 344.23 100 %
Total 344.23 100 %
Non Dermatologic 127.86 37.14 %


Twelve months ended 2025
CSTL s Annual Income by Country and Business Segments Income
(in millions $)
%
(Profit Margin)
Total 5.36 1.56 %

Twelve months ended 2025
Annual Revenue and Income Growth by Country and Business Segments % Y/Y Sales Growth % Y/Y Income Growth
Dermatologic -15.81 % -
Reportable Segment 3.66 % -
Total 3.66 % -86.55 %
Non Dermatologic 70.31 % -



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