Ascendis Pharma A's Competitiveness
A competitive positioning analysis and financial ratio benchmarking of Ascendis Pharma A (ASND) against its publicly traded competitors: sales growth, net income, profitability, valuation and market share, plus each peer's market capitalization, revenue, income and employees. Free below: the top 5 peers. Subscriber access adds the full competitor list and CSV downloads.
Key Findings: Ascendis Pharma A vs Its Competitors
- TTM: Trailing 12-month revenue of 807M vs 430M combined for tracked competitors (65.2% combined share).
- Trending: Latest-quarter revenue run-rate is accelerating (+38.4% annualized vs trailing 12 months), vs decelerating (-7.5%) for its tracked peer group.
- Growth: Ascendis Pharma A generated 49.1% revenue growth year over year in Q4 2025, vs 25.5% for its tracked competitors combined.
- Profitability: Its -15.4% net margin compares with 47.5% for the peer group.
- Scale: Ascendis Pharma A ranks #30 of 544 companies by market capitalization in the Major Pharmaceutical Preparations industry, holding 0.3% of industry market cap.
- Peer revenue share: Ascendis Pharma A accounted for 73.7% of combined revenue among its tracked peer group, up from 70.2% a year earlier.
- Peer differentiation: Revenue per employee of $8.07M compares with $0.43M for the peer group (18.7x).
Every figure above is sourced and cited in detail further down this page (Market Structure, Profitability & Cost Structure, Productivity vs Peers).
ASND Sales vs. its Competitors, Q4 2025
Ascendis Pharma A reported revenue growth of 49.14 % year on year in Q4 2025, above its competitors' combined revenue growth of 25.45 %.
With a net margin of -15.35 %, Ascendis Pharma A reported lower profitability than its competitors (47.54 %).
Ascendis Pharma A generated 73.72 % of the combined sales of its peer group, up from 70.24 % a year earlier.
Ascendis Pharma A vs. its Competitors, Q4 2025
Revenue growth, year on year
Net margin
Revenue run-rate vs trailing 12 months
TTM net margin
TTM = trailing twelve months. Run-rate annualizes the latest quarter (×4) and compares it to TTM. In millions of $. High-Confidence Competitors are named as a competitor directly in an SEC filing; Similar-Size Competitors are the closest peers by market-cap rank within the same industry; Similar Growth & Profitability Competitors are the closest peers by combined revenue growth, operating margin and ROIC, all independent of the competitor list.
TTM revenue, latest-quarter run-rate and net income/margin benchmarked across Ascendis Pharma A and its 4 competitor groupings. Available under Commercial License.
| Entity | TTM Revenue | Rev Run-rate vs TTM |
|---|---|---|
| Ascendis Pharma A | $12,345M | +12.3% · Accelerating |
| Competitors combined | $12,345M | +12.3% · Accelerating |
| High-Confidence Competitors (4) | $12,345M | +12.3% · Accelerating |
| Similar-Size Competitors (9) | $12,345M | +12.3% · Accelerating |
| Similar Growth & Profitability (5) | $12,345M | +12.3% · Accelerating |
TTM revenue, run-rate and net margin benchmarking across Ascendis Pharma A's competitor groups requires a Commercial License.
For context: the Major Pharmaceutical Preparations industry grew revenue 7.2% year over year, combined, vs 49.1% for Ascendis Pharma A. Ascendis Pharma A's share of combined industry revenue moved from 0.03% to 0.04%, a gain of 0.01 percentage points.
Ascendis Pharma A's Competitor Quality Breadth
Share of each group, trailing 12 months: profitable (net margin > 0), expanding (revenue growth > 0), growing faster than the industry's own median, and financially distressed (Piotroski F-Score of 2 or below).
| Entity | Profitable | Expanding | Above Industry Growth | Distressed |
|---|---|---|---|---|
| Ascendis Pharma A | No | Yes | Yes | No |
| Competitors combined (9) | ||||
| High-Confidence Competitors (5) | ||||
| Similar-Size Competitors (9) | ||||
| Similar Growth & Profitability (8) | 0.00 % (0 of 8) | 100.00 % (8 of 8) | 100.00 % (8 of 8) | 0.00 % (0 of 8) |
Source: CSIMarket API, trailing 12 months. Altman Z-Score is not shown here: it is not populated in the underlying data for any company. Percentages are of companies in each group that report the relevant metric, not of the full group size.
ASND Stock Performance relative to its Competitors
ASND Stock Performance relative to High-Confidence Competitors
ASND Stock Performance relative to Similar-Size Competitors
ASND Stock Performance relative to Similar Growth & Profitability Competitors
5 Best-Performing Tracked Competitors, Trailing 12 Months
| # | Competitor | TTM Share Price Return | vs U.S.A. 500 |
|---|---|---|---|
| 1 | Urogen Pharma Ltd | 282.9% | Outperformed |
| 2 | Vanda Pharmaceuticals Inc | 282.9% | Outperformed |
| 3 | Galectin Therapeutics Inc | 282.9% | Outperformed |
| 4 | Bolt Biotherapeutics Inc | 282.9% | Outperformed |
| 5 | Werewolf Therapeutics Inc | 282.9% | Outperformed |
TTM share price return and U.S.A. 500 outperformance for Ascendis Pharma A's best-performing tracked competitors requires a Commercial License.
Source: CSIMarket API, trailing 12 months.
Ascendis Pharma A's Comment on Competition and Industry Peers
Publicly Traded Peers of Ascendis Pharma A
Revenue and income for trailing 12 months, in millions of $, except employees| Company | Market Cap | Revenues |
|---|---|---|
| Ascendis Pharma A | 13,942.66 | 806.55 |
| Urogen Pharma Ltd | 2,060.55 | 188.32 |
| Vanda Pharmaceuticals Inc | 311.37 | 215.72 |
| Galectin Therapeutics Inc | 258.89 | - |
| Werewolf Therapeutics Inc | 45.20 | 16.22 |
| Oncotelic Therapeutics Inc | 11.28 | - |
| SUBTOTAL | 16,638.85 | 1,236.63 |
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Sources: Ascendis Pharma A's official press releases and regulatory filings; CSIMarket.com's market research; and the financial filings and press releases of the other companies cited.
Updated on:
Focus of this report: publicly traded companies. Ten additional tables on Ascendis Pharma A versus competitors, including market share analysis, are in the navigation menu under Competition. To download the tables, please subscribe.
Ascendis Pharma A's Competitors Named by the Company
Competitive relationships identified from SEC filings and corroborating sources, each with a basis and confidence.| Competitor | Basis | Confidence |
|---|---|---|
| Frazier | Named by the company | 85% |
| RA Capital Management | Named by the company | 85% |
| Bridgebio Pharma Inc | Named by the company | 85% |
| Mosaic Immunoengineering Inc | Named by the company | 85% |
| AEZS | Named by the company | 85% |
| HealthQuest Capital | Named by the company | 85% |
| Vetter | Named by the company | 85% |
| Medicenna Therapeutics Corp. | Named by the company | 85% |
| Frazier Life Sciences | Named by the company | 85% |
| Sharp | Named by the company | 85% |
| Cosciens Biopharma Inc | Named by the company | 85% |
| Eyconis, Inc | Named by the company | 85% |
| Lonza Ltd | Named by the company | 85% |
| VISEN | Named by the company | 85% |
| Novabridge Biosciences | Named by the company | 85% |
| Fujifilm Diosynth Biotechnologies UK Ltd. | Named by the company | 85% |
| venBio | Named by the company | 85% |
| IMAB | Named by the company | 85% |
| Bachem AG | Named by the company | 85% |
| Werewolf Therapeutics Inc | Named by the company | 85% |
Filing basis, confidence, active dates and source counts for Ascendis Pharma A's named competitors require a Commercial License.
Methodology: relationships are extracted from SEC filings (named-competitor disclosures) and corroborating sources. Named by the company = explicitly disclosed as a competitor; Inferred = derived from corroborating signals. Confidence reflects evidence strength.
Ascendis Pharma A's Business Segment Mix vs Peers
Revenue by operating segment or division, as named and reported by each company. Segment names are the filer's own and are not standardized across companies. Do not assume a same-named or similarly-named segment is defined identically between two companies. Shares are of each company's own total revenue and are not required to sum to 100% (intersegment revenue, unallocated items).| Company | Largest Segment |
|---|---|
| Vanda Pharmaceuticals Inc | Product 100.00 % |
| Werewolf Therapeutics Inc | Reportable 100.00 % |
Source: operating segment revenue as reported in each company's SEC filings (10-K/10-Q), via the CSIMarket API, leaf-level reportable segments only (parent roll-up segments are excluded where sub-segments are separately disclosed).
Ascendis Pharma A's Productivity vs Peers Comparison
Revenue and income per employee, trailing 12 months, in $; market cap in millions of $| Company | Market Cap | Revenue / Employee | Income / Employee |
|---|---|---|---|
| Ascendis Pharma A | 13,943 | 8,065,478 | -2,553,981 |
| Urogen Pharma Ltd | 2,061 | 647,137 | -335,519 |
| Vanda Pharmaceuticals Inc | 311 | 404,730 | -515,672 |
| Galectin Therapeutics Inc | 259 | - | -3,093,667 |
| Werewolf Therapeutics Inc | 45 | 415,923 | -887,513 |
| Oncotelic Therapeutics Inc | 11 | - | 6,507,381 |
| PEERS TOTAL | 2,696 | 431,807 | -311,379 |
Ascendis Pharma A's Position in Industry Market Structure
Market-capitalization share and concentration across all 498 companies in Ascendis Pharma A's industry classification, broader than the peer set above. Market cap in millions of $.Ascendis Pharma A ranks #30 of 498 companies by market capitalization in its industry, holding 0.25 % of total industry market cap. The industry's Herfindahl-Hirschman Index (HHI) is 823, indicating a unconcentrated market structure (U.S. antitrust guidance: below 1,500 unconcentrated, 1,500 to 2,500 moderately concentrated, above 2,500 highly concentrated).
| Rank | Company | Market Cap | Industry Share |
|---|---|---|---|
| 1 | Eli Lilly And Company | 1,058,838 | 19.26 % |
| 2 | Johnson and Johnson | 663,585 | 12.07 % |
| 3 | Beone Medicines Ltd | 552,468 | 10.05 % |
| 4 | Abbvie Inc | 471,582 | 8.58 % |
| 5 | Merck and Co Inc | 1,234 | 5.2% |
| 6 | Novartis Ag | 1,234 | 5.2% |
| 7 | Abbott Laboratories | 1,234 | 5.2% |
| 8 | Novo Nordisk A | 1,234 | 5.2% |
| 9 | Pfizer Inc | 1,234 | 5.2% |
| 10 | Vertex Pharmaceuticals Inc | 1,234 | 5.2% |
| 30 | Ascendis Pharma A | 13,943 | 0.25 % |
Market cap and industry share for the rest of Ascendis Pharma A's industry peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation) across CSIMarket's industry classification, market capitalization as of 2026-09-28.
Ascendis Pharma A's Same-Size Peers & Stock Performance
Peers chosen by closeness in market-cap rank within the same industry classification (not the named-competitor list above). Trailing 12-month total return, 3-month price momentum, beta and Sharpe ratio vs the broad U.S. market.| Rank | Company | Market Cap | TTM Return |
|---|---|---|---|
| 25 | Alterity Therapeutics Limited | 22,389 | -12.56 % |
| 26 | United Therapeutics Corporation | 22,238 | 11.59 % |
| 27 | Viatris Inc | 21,253 | 86.99 % |
| 28 | Jazz Pharmaceuticals Plc | 16,537 | 84.93 % |
| 29 | Madrigal Pharmaceuticals Inc | 1,234 | 12.3% |
| 30 | Ascendis Pharma A | 13,943 | 18.86 % |
| 31 | Corcept Therapeutics Inc | 1,234 | 12.3% |
| 32 | Bridgebio Pharma Inc | 1,234 | 12.3% |
| 33 | Hutchmed china Limited | 1,234 | 12.3% |
| 34 | Summit Therapeutics Inc | 1,234 | 12.3% |
| 35 | Biomarin Pharmaceutical Inc | 1,234 | 12.3% |
Market cap, return, momentum, beta and Sharpe ratio for the rest of Ascendis Pharma A's same-size peers requires a Commercial License.
Source: CSIMarket API (daily market-structure computation); returns and risk metrics as of 2026-09-28. Beta and Sharpe ratio are versus the broad U.S. equity market, not this industry.
Ascendis Pharma A's Profitability & Cost Structure
Trailing 12-month margins from SEC-filed financials. Operating margin is compared to the Major Pharmaceutical Preparations industry median; gross margin, EBITDA margin and capital intensity are compared to the live industry average (341 companies).| Metric | Company | Industry | Difference |
|---|---|---|---|
| Gross Margin | 86.82 % | 64.89 % (avg) | +21.9 pp |
| Operating Margin | -18.92 % | industry median | +7.2 pp |
| EBITDA Margin | -27.07 % | -7.21 % (avg) | -19.9 pp |
| Capital Intensity (Capex / Revenue) | - | 4.92 % (avg) | - |
Source: CSIMarket API, trailing 12 months. SG&A and R&D as a share of revenue have limited coverage as this data is backfilled and appear only where reported. Higher capital intensity is not inherently negative; it reflects the industry's asset requirements.
Ascendis Pharma A's Valuation vs Competitive Position
Valuation multiples vs the Major Pharmaceutical Preparations industry average (341 companies, excluding loss-making/negative-equity outliers), alongside returns on capital for context on whether a premium or discount lines up with measurably stronger or weaker returns.| Metric | Company | Industry Average | Difference |
|---|---|---|---|
| P/E | - | 25.1x | - |
| EV / EBITDA | - | 17.3x | - |
| P/B | -68.6x | 4.5x | -73.1x |
| Return on Equity | 140.05 % | industry aggregate | 113.80 % |
| Return on Invested Capital | -60.79 % | -2.95 % (avg) | -57.84 % |
Source: CSIMarket API, trailing 12 months. A valuation premium or discount is not, by itself, a judgment of over- or under-valuation. Compare it against the return and growth context shown elsewhere on this page.
Ascendis Pharma A's Multi-Year Financial Trajectory
Fiscal-year revenue growth, operating margin, return on invested capital and P/E, as reported in SEC filings.| Metric | 2023 | 2024 | 2025 |
|---|---|---|---|
| Revenue Growth | 403.36 % | 41.17 % | 98.03 % |
| Operating Margin | - | -76.66 % | -18.92 % |
| Return on Invested Capital | -570.62 % | -84.16 % | -60.79 % |
| P/E | - | - | - |
Source: CSIMarket API, fiscal-year figures. P/E is this company's own historical ratio at each fiscal year end and can swing sharply around an earnings trough: that is real, not a data error.
Ascendis Pharma A's Strategic Group Map
Every company in Ascendis Pharma A's industry and named-competitor list, plotted by trailing 12-month revenue growth and operating margin. Ascendis Pharma A is shown in red; its closest peers by combined growth, margin and ROIC (the Similar Growth & Profitability group above) are labeled.
Source: CSIMarket API, trailing 12 months. Extreme outlier values (from near-zero-revenue companies) are excluded from the plotted cloud but never from the highlighted company or its labeled peers.
Ascendis Pharma A's BCG Growth-Share Matrix
Relative market share (vs Ascendis Pharma A's largest competitor by market cap) against industry revenue growth, using the standard textbook thresholds (1.0x share, 10% growth) a common framework, not a precision instrument.
Ascendis Pharma A falls in the Dog quadrant: relative market share of 0.01x vs its largest competitor, in an industry growing revenue 8.0% (median, trailing 12 months).
Source: CSIMarket API (market-cap share and industry revenue growth). The 10% growth and 1.0x share lines are standard textbook thresholds, not derived from this industry's own distribution.
Ascendis Pharma A's Competitive Forces (Porter's Five Forces)
Only the forces this data can support honestly are shown; the other three are marked as such rather than guessed.| Force | Assessment | Basis |
|---|---|---|
| Competitive Rivalry | High | Industry HHI of 823 (see Industry Market Structure & Concentration above) |
| Supplier Power | Not covered on this page | See Ascendis Pharma A's dedicated suppliers page for concentration and dependency data |
| Buyer Power | Not covered on this page | See Ascendis Pharma A's dedicated customers page for concentration and dependency data |
| Threat of Substitutes | - | No systematic data source for cross-product substitution exists in this system; not estimated |
Note: this is a partial, data-grounded application of the framework, not a complete strategic assessment. Rivalry and barriers-to-entry readings are mechanical translations of the HHI and capital-intensity figures shown elsewhere on this page, not independent judgments.
Ascendis Pharma A's Industry Attractiveness & Competitive Strength
A CSIMarket composite, not a standard field: each axis is an equal-weighted average of three factors already shown elsewhere on this page (industry growth, industry profitability and rivalry for attractiveness; relative market share, profitability and growth vs industry for strength). Disclosed as a designed methodology, not a precision measurement.
Ascendis Pharma A falls in the Low attractiveness / Medium strength cell: Harvest.
Source: CSIMarket API, trailing 12 months. Each axis score is a simple 1(low)/2(medium)/3(high) average across its three inputs -- a transparent, disclosed simplification, not a validated academic scoring model.
Ascendis Pharma A's SWOT
Every point below is a fixed rule applied to a metric already shown elsewhere on this page (Market Structure, Profitability, Valuation, Run-Rate, Stock Performance, Quality Breadth) not an independent strategic assessment. A blank quadrant means no rule was met, not that none apply.Strengths
- Operating margin 7.2 points above the industry median.
- Return on equity 113.8 points above the industry aggregate.
- Latest-quarter revenue run-rate is accelerating (+38.4% annualized vs trailing 12 months).
- Outperforming the U.S.A. 500 over the trailing 12 months.
Weaknesses
- Low relative market share vs the industry leader (0.01x).
Opportunities
- A meaningful share of tracked competitors (75.00 %) show financial-distress signals, a possible opening to gain share.
Threats
- Tracked peer group's revenue run-rate is broadly decelerating (-7.5% annualized).
Methodology: mechanical, rule-based SWOT. Each bullet reuses a figure already sourced and cited elsewhere on this page; nothing here is generated narrative or independent analyst judgment.
Ascendis Pharma A's Financial Strength vs Peers Comparison
Quick ratio, working capital, debt to equity and asset turnover, trailing 12 months| Company | Quick Ratio | Working Capital | Debt / Equity |
|---|---|---|---|
| Ascendis Pharma A | 0.58 | 1.04 | - |
| Urogen Pharma Ltd | 2.08 | 4.11 | - |
| Vanda Pharmaceuticals Inc | 0.47 | 2.26 | - |
| Galectin Therapeutics Inc | 0.19 | 0.21 | - |
| Werewolf Therapeutics Inc | 1.91 | 1.98 | 1.02 |
| Oncotelic Therapeutics Inc | 0.01 | 0.09 | 0.02 |
Quick ratio = cash / current liabilities; working capital ratio = current assets / current liabilities; asset turnover = revenue / total assets. Peers in the Blank Checks industry are excluded.
Ascendis Pharma A's Revenue and Income Growth vs Peers
Quarterly revenue and net income growth, year over year and quarter over quarter| Company | Period | Revenue Y/Y | Income Y/Y |
|---|---|---|---|
| Ascendis Pharma A | Q4 2025 | +98.0 % | - |
| Urogen Pharma Ltd | Q2 2026 | +206.2 % | - |
| Vanda Pharmaceuticals Inc | Q2 2026 | -3.9 % | - |
| Galectin Therapeutics Inc | Q2 2026 | - | - |
| Werewolf Therapeutics Inc | Q2 2026 | - | - |
| Oncotelic Therapeutics Inc | Q2 2026 | - | +62.0 % |
| PEERS TOTAL | +95.5 % | - |
Growth is shown only where both periods are positive. Peers in the Blank Checks industry are excluded.
Ascendis Pharma A's Peers' Costs of Sales and Capital Expenditures
Context for revenue growth: peer costs and capex, year over year and quarter over quarter| Company | Period | Costs Y/Y | Capex Y/Y |
|---|---|---|---|
| Ascendis Pharma A | Q4 2025 | +114.5 % | - |
| Urogen Pharma Ltd | Q2 2026 | +85.1 % | -57.4 % |
| Vanda Pharmaceuticals Inc | Q2 2026 | +30.1 % | -36.5 % |
| Galectin Therapeutics Inc | Q2 2026 | - | - |
| Werewolf Therapeutics Inc | Q2 2026 | - | - |
| Oncotelic Therapeutics Inc | Q2 2026 | - | - |
Ascendis Pharma A's Returns and Turnover vs Peers
ROA, ROI and ROE (trailing 12 months), receivables and inventory turnover| Company | ROA | ROI | ROE |
|---|---|---|---|
| Ascendis Pharma A | - | - | - |
| Urogen Pharma Ltd | - | - | - |
| Vanda Pharmaceuticals Inc | - | - | - |
| Galectin Therapeutics Inc | - | - | - |
| Werewolf Therapeutics Inc | - | - | - |
| Oncotelic Therapeutics Inc | 81.75% | 87.35% | 124.17% |
ROA = net income / total assets; ROI = net income / investments; ROE = net income / equity; turnover ratios use trailing 12 month revenue (receivables) and cost of sales (inventory).
Ascendis Pharma A's Valuation vs Peers
P/E, price to sales, PEG, price to cash flow and price to book| Company | P/E | Price / Sales |
|---|---|---|
| Ascendis Pharma A | - | 17.29 |
| Urogen Pharma Ltd | - | 10.94 |
| Vanda Pharmaceuticals Inc | - | 1.44 |
| Galectin Therapeutics Inc | - | - |
| Werewolf Therapeutics Inc | - | 2.79 |
| Oncotelic Therapeutics Inc | - | - |
| PEERS AVERAGE | - | 13.46 |
P/E = price / diluted EPS (trailing 12 months); PEG = P/E divided by EPS growth; the average row divides the peers' combined market cap by their combined income, sales, cash flow and equity.