CSIMarket
 
Denali Therapeutics Inc   (NASDAQ: DNLI)
 
Price: $21.5700 $-0.51 -2.310%
Day's High: $22.059999465942383 Week Perf: -5.6 %
Day's Low: $ 21.34 30 Day Perf: -13.72 %
Volume (M): 2,091,296 52 Wk High: $ 27.30
Volume (M$): $ 0 52 Wk Avg: $19.79
Open: $21.69 52 Wk Low: $12.58



 Market Capitalization (Millions $) 4,040
 Shares Outstanding (Millions) 187
 Employees 503
 Revenues (TTM) (Millions $) 4
 Net Income (TTM) (Millions $) 1
 Cash Flow (TTM) (Millions $) 246
 Capital Exp. (TTM) (Millions $) 35

Business Description


Denali Therapeutics Inc is a biotechnology company that focuses on discovering and developing treatments for neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and Huntington's disease.
The company was founded in 2015 by a group of leading scientists and drug developers from Genentech, including Ryan Watts, Alex Schuth, and Marc Tessier-Lavigne.
Denali's approach to drug development is based on the use of proprietary technologies such as the Transport Vehicle platform and the Neuroimmunology platform.
The Transport Vehicle platform is designed to allow large molecules such as antibodies to cross the blood-brain barrier, which is essential for treating neurodegenerative diseases.
The Neuroimmunology platform is focused on developing therapies that modulate the immune system's response to neurodegenerative diseases.
Currently, Denali has several drug candidates in its pipeline that are designed to address the underlying biology of neurodegenerative diseases.
One of the company's lead drug candidates is DNL151, an oral small molecule inhibitor of leucine-rich repeat kinase 2 (LRRK2), which is a genetically validated target for Parkinson's disease.
Denali also has a collaboration with Sanofi to develop potential treatments for multiple sclerosis and other neuroinflammatory disorders.
The company is headquartered in South San Francisco, California, and has over 400 employees, including scientists, researchers, and drug developers with extensive experience in the biotechnology industry.
Denali has received over $600 million in funding from leading investors such as Fidelity, Flagship Pioneering, and the Alaska Permanent Fund Corporation.
Overall, Denali is focused on developing breakthrough therapies that have the potential to improve the lives of patients with neurodegenerative diseases.


   Company Address: 161 Oyster Point Blvd South San Francisco 94080 CA
   Company Phone Number: 866-8547   Stock Exchange / Ticker: NASDAQ DNLI


   

Stock Performances by Major Competitors

5 Days Decrease / Increase
     
ABOS   -2.4%    
ALEC   -5.42%    
GILD   -2.85%    
HALO   -0.31%    
OCGN   -19.92%    
RXRX   -3.45%    
• View Complete Report
   



Product Service News

Navigating New Frontiers in Rare Disease and Neurodegeneration Denali Therapeutics’ Pivotal Milestones

Published Tue, Oct 14 2025 8:18 AM UTC

Denali Therapeutics’ Recent Announcements: Key Facts and Implications Denali Therapeutics Inc., a cutting-edge biopharmaceutical company, is making significant strides in addressing complex and rare diseases through innovative therapeutic approaches. Recent press releases from the company detail two crucial developments: the extension of the FDA review timeline for the Bio...

Management Announcement

Denali Therapeutics Charts Ambitious Course for 2025 Amid Financial Challenges and Pivotal FDA Discussions on Hunter Syndrome Therapy,

Published Mon, Jan 13 2025 1:02 PM UTC

Denali Therapeutics Sets Ambitious 2025 Milestones Despite Financial StrugglesDenali Therapeutics Inc. a biotech firm focused on developing therapies for neurodegeneration and lysosomal storage diseases, recently outlined its key anticipated milestones for 2025. The company’s Chief Executive Officer, Ryan Watts, Ph.D. is scheduled to present these goals at the 43rd Annual...

Clinical Study

Denali Therapeutics Moves Forward with Accelerated Approval Plans for Tividenofusp Alfa amid Market Challenges

Published Tue, Sep 3 2024 12:01 PM UTC

Denali Therapeutics Inc. has recently announced a successful meeting with the U.S. Food and Drug Administration (FDA) concerning its investigational therapeutic, Tividenofusp Alfa (DNL310), aimed at treating Mucopolysaccharidosis Type II (MPS II), commonly known as Hunter Syndrome. The meeting was a significant milestone for the company, as it signals a forthcoming applicati...

Clinical Study

The Promising Advancements in Oligonucleotide Transport for Neurological Treatment A Discourse on Denali Therapeutics...

Published Wed, Aug 14 2024 6:00 PM UTC

In the venerable realm of biopharmaceutical innovation, the illustrious Denali Therapeutics Inc., headquartered in the charming enclave of South San Francisco, has recently revealed a monumental stride in medical science, one that reverberates with profound implications for the treatment of neurodegenerative and lysosomal storage maladies. The company, whose endeavours are p...

Clinical Study

Denali Therapeutics Completes Enrollment for Regimen G in Phase 2/3 HEALEY ALS Platform Trial, Signifying Progress in Neurodegenerative Disease Treatment

Published Wed, May 1 2024 12:01 PM UTC

Denali Therapeutics Inc., a leading biopharmaceutical company committed to developing innovative treatment options for neurodegenerative and lysosomal storage diseases, has announced the successful completion of enrollment for Regimen G in the Phase 2/3 HEALEY ALS Platform Trial. This achievement marks a significant milestone for both Denali Therapeutics and the field of neu...




Fundamental Analysis

Valuation Current
Price to Earnings PE Ratio (TTM) -
Price to Earnings PE Ratio (Expected) -
Price to Sales (TTM) 1,121.08
Price to Sales (Expected) -
Price to Book 4.84
PEG (TTM) -

Financial Strength Current
Quick Ratio 7.89
Working Capital Ratio 8.37
Leverage Ratio (MRQ) 0.39
Total Debt to Equity -
Interest Coverage (TTM) -
Debt Coverage (TTM) -

Per Share Current
Earnings (TTM) -2.85 $
Revenues (TTM) 0.02 $
Cash Flow (TTM) 1.32 $
Cash 3.79 $
Book Value 4.46 $
Dividend (TTM) 0 $

Efficiency Current
Revenue per Employee (TTM) 7,165
Net Income per Employee (TTM) 1,962
Receivable Turnover Ratio (TTM) 1.84
Inventory Turnover Ratio (TTM) 0.04
Asset Turnover Ratio (TTM) 0

Profitability Ratios Current
Gross Margin (MRQ) 97.42 %
Operating Margin (MRQ) -3622.11 %
Net Margin (MRQ) -3539.21 %
Net Cash Flow Margin (MRQ) 0 %
Effective Tax Rate (TTM) -

Management Effectiveness Current
Return On Assets (TTM) 0.09 %
Return On Investment (TTM) 0.09 %
Return On Equity (TTM) 0.11 %
Dividend Yield -
Pay out Ratio (TTM) -



Denali Therapeutics Inc's Segments
Milestone Triggered    2774.69 % of total Revenue
Option Fee Payment    277.47 % of total Revenue
Milestone Payment    277.47 % of total Revenue





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