The company manufactures the eCRM protein using raw materials such as E. coli extracts and lysates for in vitro DNA transcription and translation. Pneumococcal polysaccharides are isolated from Streptococcus pneumoniae strains cultured in bioreactors through a standardized fed-batch process. Conjugate drug substances are produced by conjugating activated pneumococcal polysaccharide strains to the eCRM protein using click chemistry. Final drug products are formulated, adsorbed onto alum, filled into vials, and refrigerated. The company does not own manufacturing facilities but maintains strategic partnerships with Lonza and other contract manufacturing organizations (CMOs) for the production of eCRM, polysaccharides, drug substances, and final drug products. Agreements with Lonza provide capacity, expertise, and commercial manufacturing support, while an agreement with Sutro Biopharma supplies extracts and custom reagents used in eCRM manufacturing.
Vaxcyte Inc's Comment on Supply Chain
The company manufactures the eCRM protein using raw materials such as E. coli extracts and lysates for in vitro DNA transcription and translation. Pneumococcal polysaccharides are isolated from Streptococcus pneumoniae strains cultured in bioreactors through a standardized fed-batch process. Conjugate drug substances are produced by conjugating activated pneumococcal polysaccharide strains to the eCRM protein using click chemistry. Final drug products are formulated, adsorbed onto alum, filled into vials, and refrigerated. The company does not own manufacturing facilities but maintains strategic partnerships with Lonza and other contract manufacturing organizations (CMOs) for the production of eCRM, polysaccharides, drug substances, and final drug products. Agreements with Lonza provide capacity, expertise, and commercial manufacturing support, while an agreement with Sutro Biopharma supplies extracts and custom reagents used in eCRM manufacturing.
Sources:
Vaxcyte Inc 's official press releases and regulatory filings; CSIMarket.com's supply-chain research; and the financial filings and press releases of other companies cited in this report.
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