Sionna Therapeutics Inc (SION) Return on Investment ROI from the second quarter of 2026 to second quarter of 2025 and for the year 2026, average high and low, overall ranking from Jun 30 2026 to Jun 30 2025 - CSIMarket
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Sionna Therapeutics Inc   (NASDAQ: SION)


Sionna Therapeutics Inc's ROI from its second quarter of 2026 to the second quarter of 2025 and 5 Year Period

Return on Investment, Quarterly Results, Trends, Rankings, Statistics

What is Sionna Therapeutics Inc's ROI in the second quarter of 2026?
Sionna Therapeutics Inc recorded a cumulative net loss of $-97 million during 12 months ending in the second quarter of 2026, resulting in a negative return on investment (ROI) of -32.16%.

Within the Healthcare sector 375 other companies had a higher return on investment. While return on investment, the total ranking has deteriorated compared to the first quarter of 2026 from 2855 to 3444.

Definition and Formula of Return on Investment



Return On Investment (Jun 30 2026)
II. Quarter
(Mar 31 2026)
I. Quarter
(Dec 31 2025)
IV. Quarter
(Sep 30 2025)
III. Quarter
(Jun 30 2025)
II. Quarter
Y / Y Investment Change TTM 38.69 % 142.63 % 698.67 % - -
Y / Y Net Income Change TTM - - - - -
Investment (TTM) in Millions 272 295 314 329 344
Return On Investment (TTM) -32.16 % -26.67 % -22.33 % -23.5 % -34.73 %
SION's Overall Ranking # 3444 # 2855 # 3018 # 0 # 0
Seq. Investment Change TTM -5.61 % -4.81 % 12.09 % 37.71 % 65.13 %
Seq. Net Income Change TTM - - - - -
Net Income (TTM) in Millions -97 -86 -75 -71 -76




Return On Investment SION's Ranking
Within: No.
Industry # 147
Sector # 376
Overall # 3444

Return On Investment Statistics
High Average Low
-18.31 %
-24.86 %
-32.16 %
(Mar 31 2025)   (Jun 30 2026)







Financial Statements
Sionna Therapeutics Inc's II. Quarter Investments $ 272 Millions SION's Balance sheet
Sionna Therapeutics Inc's II. Quarter Income $ -30 Millions Quarterly SION's Income Statement
SION's Income by Division See SION's Income by Division


SION Annual Return On Investment (Dec 31 2025)
2025




Total Investments in Millions 314 0 0 0 0
Y / Y Investment Growth - - - - -
Net Income in Millions -75 0 0 0 0
Y / Y Net Income Growth - - - - -
Annual Return On Investment -23.95 % - - - -


Annual Roi Comment


Definition and Formula of Return on Investment

Other ROI Ratios
Major Pharmaceutical Preparations Industry Roi Trends and Statistics
Healthcare Sector Return On Investment Statistics
Roi Trends for overall market
SION's Roi Ratio versus Major Pharmaceutical Preparations Industry, Healthcare Sector and total Market
Highest Ranking Return On Investment
Lowest Ranking Return On Investment
Subscribers only: Roi for SION's Competitors
Subscribers only: Roi for Sionna Therapeutics Inc's Suppliers
Subscribers only: Return On Investment for SION's Customers

Other Ratios
SION's Roa SION's Inventory Turnover Ratio SION's Growth Rates SION's Dividend Statistics
SION's Profitability Ratios SION's Asset Turnover Ratio SION's Dividend Growth
SION's Roe SION's Valuation Ratios SION's Financial Strength Ratios SION's Dividend Payout Ratio



Companies with similar Return On Investment at Jun 30 2026, within Healthcare Sector ROI


Date modified: 2026-09-26T07:43:24+00:00



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