Ionis Pharmaceuticals Inc (IONS) Return on Investment ROI from the second quarter of 2026 to second quarter of 2025 and for the year 2026, average high and low, overall ranking from Jun 30 2026 to Mar 31 2025 - CSIMarket
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Ionis Pharmaceuticals Inc   (NASDAQ: IONS)


Ionis Pharmaceuticals Inc's ROI from its second quarter of 2026 to the second quarter of 2025 and 5 Year Period

Return on Investment, Quarterly Results, Trends, Rankings, Statistics

What is Ionis Pharmaceuticals Inc's ROI in the second quarter of 2026?
Ionis Pharmaceuticals Inc recorded a cumulative net loss of $-313 million during 12 months ending in the second quarter of 2026, resulting in a negative return on investment (ROI) of -11.82%.

Within the Healthcare sector 79 other companies had a higher return on investment. While return on investment, the total ranking has deteriorated compared to the first quarter of 2026 from 3005 to 3116.

Definition and Formula of Return on Investment


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Return On Investment (Jun 30 2026)
II. Quarter		 (Mar 31 2026)
I. Quarter		 (Dec 31 2025)
IV. Quarter		 (Jun 30 2025)
II. Quarter		 (Mar 31 2025)
I. Quarter
Y / Y Investment Change TTM 27.32 % 27.87 % 30.25 % 32.21 % 4.69 %
Y / Y Net Income Change TTM - - - - -
Investment (TTM) in Millions 2,679 2,733 2,945 2,233 2,563
Return On Investment (TTM) -11.82 % -13.19 % -13.66 % -10.43 % -22.03 %
IONS's Overall Ranking # 3116 # 3005 # 0 # 0 #
Seq. Investment Change TTM 1.11 % 0.18 % 1.63 % 23.68 % 1.54 %
Seq. Net Income Change TTM - - - - -
Net Income (TTM) in Millions -313 -345 -357 -268 -458

IONS Company Profile >> Back to IONS Roi Comparisons >> See Annual IONS Return On Investment



Return On Investment IONS's Ranking
Within: No.
Industry # 20
Sector # 80
Overall # 3116

Return On Investment Statistics
High Average Low
14.69 %
-6.7 %
-29.06 %
(Sep 30 2019)   (Jun 30 2016)







Financial Statements
Ionis Pharmaceuticals Inc's II. Quarter Investments $ 2,679 Millions IONS's Balance sheet
Ionis Pharmaceuticals Inc's II. Quarter Income $ -115 Millions Quarterly IONS's Income Statement
IONS's Income by Division See IONS's Income by Division


IONS Annual Return On Investment (Sep 30 2025)
2025		 (Dec 31 2024)
2024		 (Dec 31 2023)
2023		 (Dec 31 2022)
2022		 (Dec 31 2021)
2021
Total Investments in Millions 2,130 2,706 2,542 2,222 2,371
Y / Y Investment Growth -21.3 % 6.45 % 14.38 % -6.28 % 31.26 %
Net Income in Millions -129 -454 -366 -270 -29
Y / Y Net Income Growth - - - - -
Annual Return On Investment -6.04 % -16.77 % -14.41 % -12.14 % -1.21 %


Annual Roi Comment


Definition and Formula of Return on Investment

Other ROI Ratios
Major Pharmaceutical Preparations Industry Roi Trends and Statistics
Healthcare Sector Return On Investment Statistics
Roi Trends for overall market
IONS's Roi Ratio versus Major Pharmaceutical Preparations Industry, Healthcare Sector and total Market
Highest Ranking Return On Investment
Lowest Ranking Return On Investment
Subscribers only: Roi for IONS's Competitors
Subscribers only: Roi for Ionis Pharmaceuticals Inc's Suppliers
Subscribers only: Return On Investment for IONS's Customers

Other Ratios
IONS's Roa IONS's Inventory Turnover Ratio IONS's Growth Rates IONS's Dividend Statistics
IONS's Profitability Ratios IONS's Asset Turnover Ratio IONS's Dividend Growth
IONS's Roe IONS's Valuation Ratios IONS's Financial Strength Ratios IONS's Dividend Payout Ratio



Companies with similar Return On Investment at Jun 30 2026, within Healthcare Sector ROI

Date modified: 2026-08-13T08:57:28+00:00



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