Shuttle Pharmaceuticals Holdings Inc (SHPH) Return on Investment ROI from the second quarter of 2026 to second quarter of 2025 and for the year 2026, average high and low, overall ranking from Jun 30 2026 to Jun 30 2025 - CSIMarket
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Shuttle Pharmaceuticals Holdings Inc   (NASDAQ: SHPH)


Shuttle Pharmaceuticals Holdings Inc's ROI from its second quarter of 2026 to the second quarter of 2025 and 5 Year Period

Return on Investment, Quarterly Results, Trends, Rankings, Statistics

What is Shuttle Pharmaceuticals Holdings Inc's ROI in the second quarter of 2026?
Shuttle Pharmaceuticals Holdings Inc recorded a cumulative net loss of $-10 million during 12 months ending in the second quarter of 2026, resulting in a negative return on investment (ROI) of -152.45%.

Within the Healthcare sector 689 other companies had a higher return on investment. While return on investment, the total ranking has deteriorated compared to the first quarter of 2026 from 4299 to 4363.

Definition and Formula of Return on Investment


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Return On Investment (Jun 30 2026)
II. Quarter		 (Mar 31 2026)
I. Quarter		 (Dec 31 2025)
IV. Quarter		 (Sep 30 2025)
III. Quarter		 (Jun 30 2025)
II. Quarter
Y / Y Investment Change TTM 267.45 % 130.67 % 144.16 % 14.77 % -54.69 %
Y / Y Net Income Change TTM - - - - -
Investment (TTM) in Millions 19 4 3 2 4
Return On Investment (TTM) -152.45 % -379.61 % -410.32 % -432.97 % -662.91 %
SHPH's Overall Ranking # 4363 # 4299 # 3747 # 4024 # 3610
Seq. Investment Change TTM 136.1 % -0.21 % 15.54 % 34.99 % 48.21 %
Seq. Net Income Change TTM - - - - -
Net Income (TTM) in Millions -10 -11 -12 -11 -12

SHPH Company Profile >> Back to SHPH Roi Comparisons >> See Annual SHPH Return On Investment



Return On Investment SHPH's Ranking
Within: No.
Industry # 317
Sector # 690
Overall # 4363

Return On Investment Statistics
High Average Low
-56.63 %
-301.47 %
-846.96 %
(Mar 31 2023)   (Mar 31 2025)



  News about Shuttle Pharmaceuticals Holdings Inc Return on Investment ROI

Shuttle Pharmaceuticals Reports Financial Struggles Amid Focus on Cancer Treatments

November 13, 2024

In a recent corporate update, Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) revealed a challenging financial landscape as it navigates the complexities of the oncology market. The Gaithersburg, Maryland-based company, known for its commitment to enhancing outcomes for cancer patients undergoing radiation therapy, reported a notable decline in its stock value and significant net losses for the period ending September 30, 2024.During the month of November, the company s shares plummeted by 19.16%, reflecting investor concerns over its financial viability and market performance. The quarterly report indicated an alarming cumulative net loss of $7 million over the twelve months leading into the second quarter of 2024. This troubling performance translated into a staggering negative return on investment (ROI) of -178.02%, raising questions about the sustainability of Shuttle Pharmaceuticals business model and its strategic direction.

Shuttle Pharma Pays Off Senior Secured Convertible Note

October 29, 2024

Shuttle Pharmaceuticals Advances Strategic Goals through Debt Payoff and New Public OfferingIn a notable demonstration of fiscal responsibility and strategic growth, Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH), a Maryland-based specialty pharmaceutical company dedicated to improving outcomes for cancer patients undergoing radiation therapy, has recently completed significant financial maneuvers. On October 29, 2024, the company announced it has fully paid off its Senior Secured Convertible Note, originally issued on January 11, 2023. This decisive action reflects Shuttle Pharma’s commitment to maintaining a strong fiscal foundation while concurrently paving the way for future clinical advancements.The settlement of the outstanding balance under the Senior Secured Convertible Note highlights Shuttle Pharma’s focus on financial health and a reduction of debt obligations, which are crucial during a period of ongoing clinical trials and product development. By alleviating these financial liabilities, Shuttle Pharma not only enhances its balance sheet but also positions itself more favorably for future investments and operational initiatives.





Financial Statements
Shuttle Pharmaceuticals Holdings Inc's II. Quarter Investments $ 19 Millions SHPH's Balance sheet
Shuttle Pharmaceuticals Holdings Inc's II. Quarter Income $ -3 Millions Quarterly SHPH's Income Statement
SHPH's Income by Division See SHPH's Income by Division


SHPH Annual Return On Investment (Dec 31 2025)
2025		 (Dec 31 2024)
2024		 (Dec 31 2023)
2023		 (Dec 31 2022)
2022
Total Investments in Millions 3 1 5 8 0
Y / Y Investment Growth 158.01 % -80.19 % -36.06 % - -
Net Income in Millions -12 -9 -7 -3 0
Y / Y Net Income Growth - - - - -
Annual Return On Investment -467.17 % -940.35 % -134.28 % -39.44 % -


Annual Roi Comment


Definition and Formula of Return on Investment

Other ROI Ratios
Major Pharmaceutical Preparations Industry Roi Trends and Statistics
Healthcare Sector Return On Investment Statistics
Roi Trends for overall market
SHPH's Roi Ratio versus Major Pharmaceutical Preparations Industry, Healthcare Sector and total Market
Highest Ranking Return On Investment
Lowest Ranking Return On Investment
Subscribers only: Roi for SHPH's Competitors
Subscribers only: Roi for Shuttle Pharmaceuticals Holdings Inc's Suppliers
Subscribers only: Return On Investment for SHPH's Customers

Other Ratios
SHPH's Roa SHPH's Inventory Turnover Ratio SHPH's Growth Rates SHPH's Dividend Statistics
SHPH's Profitability Ratios SHPH's Asset Turnover Ratio SHPH's Dividend Growth
SHPH's Roe SHPH's Valuation Ratios SHPH's Financial Strength Ratios SHPH's Dividend Payout Ratio



Companies with similar Return On Investment at Jun 30 2026, within Healthcare Sector ROI

Date modified: 2026-09-25T05:02:31+00:00



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