Lyra Therapeutics Inc (LYRA) Return on Investment ROI from the fourth quarter of 2025 to fourth quarter of 2024 and for the year 2025, average high and low, overall ranking from Dec 31 2025 to Dec 31 2024 - CSIMarket
CSIMarket Company Name, Ticker, Competitors, else..
 


• ROA Quarterly
• ROI Quarterly
• ROE Quarterly
Lyra Therapeutics Inc   (NASDAQ: LYRA)


Lyra Therapeutics Inc's ROI from its fourth quarter of 2025 to the fourth quarter of 2024 and 5 Year Period

Return on Investment, Quarterly Results, Trends, Rankings, Statistics

What is Lyra Therapeutics Inc's ROI in the fourth quarter of 2025?
Lyra Therapeutics Inc recorded a cumulative net loss of $-29 million during 12 months ending in the fourth quarter of 2025, resulting in a negative return on investment (ROI) of -80.44%.

Within the Healthcare sector 706 other companies had a higher return on investment. While return on investment, the total ranking has deteriorated compared to the third quarter of 2025 from 3741 to 4052.

Definition and Formula of Return on Investment


Download as CSV
Commercial Data Licensing & OEM
Annual commercial subscriptions for corporate use, internal BI systems, management reporting, AI integration, and client-facing platforms
API & Data Feeds
Programmatic access to normalized fundamentals & ratios.

Return On Investment (Dec 31 2025)
IV. Quarter		 (Sep 30 2025)
III. Quarter		 (Jun 30 2025)
II. Quarter		 (Mar 31 2025)
I. Quarter		 (Dec 31 2024)
IV. Quarter
Y / Y Investment Change TTM -54.44 % -54.74 % -51.76 % -48.19 % -24.06 %
Y / Y Net Income Change TTM - - - - -
Investment (TTM) in Millions 23 34 41 45 54
Return On Investment (TTM) -80.44 % -75.65 % -76.23 % -133.85 % -118.41 %
LYRA's Overall Ranking # 4052 # 3741 # 3215 # 3182 # 3192
Seq. Investment Change TTM -17.44 % -14.51 % -14.26 % -24.7 % -18 %
Seq. Net Income Change TTM - - - - -
Net Income (TTM) in Millions -29 -33 -39 -80 -93

LYRA Company Profile >> Back to LYRA Roi Comparisons >> See Annual LYRA Return On Investment



Return On Investment LYRA's Ranking
Within: No.
Industry # 156
Sector # 707
Overall # 4052

Return On Investment Statistics
High Average Low
-31.28 %
-73.86 %
-133.85 %
(Dec 31 2020)   (Mar 31 2025)







Financial Statements
Lyra Therapeutics Inc's IV. Quarter Investments $ 23 Millions LYRA's Balance sheet
Lyra Therapeutics Inc's IV. Quarter Income $ -7 Millions Quarterly LYRA's Income Statement
LYRA's Income by Division See LYRA's Income by Division


LYRA Annual Return On Investment (Dec 31 2025)
2025		 (Dec 31 2024)
2024		 (Dec 31 2023)
2023		 (Dec 31 2022)
2022		 (Dec 31 2021)
2021
Total Investments in Millions 7 54 123 95 37
Y / Y Investment Growth -86.11 % -56.33 % 28.8 % 160.77 % -51.78 %
Net Income in Millions -29 -93 -63 -55 -44
Y / Y Net Income Growth - - - - -
Annual Return On Investment -387.5 % -173.95 % -50.96 % -57.88 % -118.82 %


Annual Roi Comment


Definition and Formula of Return on Investment

Other ROI Ratios
Medical Equipment & Supplies Industry Roi Trends and Statistics
Healthcare Sector Return On Investment Statistics
Roi Trends for overall market
LYRA's Roi Ratio versus Medical Equipment & Supplies Industry, Healthcare Sector and total Market
Highest Ranking Return On Investment
Lowest Ranking Return On Investment
Subscribers only: Roi for LYRA's Competitors
Subscribers only: Roi for Lyra Therapeutics Inc's Suppliers
Subscribers only: Return On Investment for LYRA's Customers

Other Ratios
LYRA's Roa LYRA's Inventory Turnover Ratio LYRA's Growth Rates LYRA's Dividend Statistics
LYRA's Profitability Ratios LYRA's Asset Turnover Ratio LYRA's Dividend Growth
LYRA's Roe LYRA's Valuation Ratios LYRA's Financial Strength Ratios LYRA's Dividend Payout Ratio



Companies with similar Return On Investment at Dec 31 2025, within Healthcare Sector ROI

Date modified: 2026-07-07T12:01:06+00:00



Help

About us

Products

Data downloads

API

CSIMarket Company, Sector, Industry, Market Analysis, Stock Quotes, Earnings, Economy, News and Research.

Intraday data delayed per exchange requirements. All quotes are in local exchange time. Intraday data delayed 15 minutes for Nasdaq, and other exchanges. Fundamental and financial data for Stocks, Sector, Industry, and Economic Indicators provided by CSIMarket.com

Disclaimer: Information provided by CSIMarket.com is for informational purposes only and does not constitute investment advice, recommendation, or solicitation to buy or sell any security.

© 2026 CSIMarket.com — Proprietary financial dataset. All rights reserved. Redistribution or automated extraction prohibited.