Karyopharm Therapeutics Inc (KPTI) Return on Investment ROI from the second quarter of 2026 to second quarter of 2025 and for the year 2026, average high and low, overall ranking from Jun 30 2026 to Jun 30 2025 - CSIMarket
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Karyopharm Therapeutics Inc   (NASDAQ: KPTI)


Karyopharm Therapeutics Inc's ROI from its second quarter of 2026 to the second quarter of 2025 and 5 Year Period

Return on Investment, Quarterly Results, Trends, Rankings, Statistics

What is Karyopharm Therapeutics Inc's ROI in the second quarter of 2026?
Karyopharm Therapeutics Inc recorded a cumulative net loss of $-225 million during 12 months ending in the second quarter of 2026, resulting in a negative return on investment (ROI) of -5405.65%.

Within the Healthcare sector 751 other companies had a higher return on investment. While Return on investment, overall ranking has progressed in the Jun 30 2026 quarter, so far to 4234, from total ROI ranking in the first quarter of 2026 at 4878.

Definition and Formula of Return on Investment


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Return On Investment (Jun 30 2026)
II. Quarter		 (Mar 31 2026)
I. Quarter		 (Dec 31 2025)
IV. Quarter		 (Sep 30 2025)
III. Quarter		 (Jun 30 2025)
II. Quarter
Y / Y Investment Change TTM -93.16 % -88.52 % -86.19 % -79.1 % -63.94 %
Y / Y Net Income Change TTM - - - - -
Investment (TTM) in Millions -23 14 16 9 6
Return On Investment (TTM) - -1725.05 % -1145.84 % -401.25 % -203.28 %
KPTI's Overall Ranking # 4234 # 4878 # 4160 # 4096 # 3699
Seq. Investment Change TTM -63.22 % -33.94 % -44.91 % -48.9 % -38.26 %
Seq. Net Income Change TTM - - - - -
Net Income (TTM) in Millions -225 -195 -196 -125 -124

KPTI Company Profile >> Back to KPTI Roi Comparisons >> See Annual KPTI Return On Investment



Return On Investment KPTI's Ranking
Within: No.
Industry # 359
Sector # 752
Overall # 4234

Return On Investment Statistics
High Average Low
-31.84 %
-72.27 %
-229.28 %
(Mar 31 2025)   (Jun 30 2026)







Financial Statements
Karyopharm Therapeutics Inc's II. Quarter Investments $ -23 Millions KPTI's Balance sheet
Karyopharm Therapeutics Inc's II. Quarter Income $ -67 Millions Quarterly KPTI's Income Statement
KPTI's Income by Division See KPTI's Income by Division


KPTI Annual Return On Investment (Dec 31 2025)
2025		 (Dec 31 2024)
2024		 (Dec 31 2023)
2023		 (Dec 31 2022)
2022		 (Dec 31 2021)
2021
Total Investments in Millions 16 72 171 292 232
Y / Y Investment Growth -77.33 % -57.79 % -41.51 % 26.2 % -8.41 %
Net Income in Millions -196 -76 -143 -165 -124
Y / Y Net Income Growth - - - - -
Annual Return On Investment -1198.58 % -105.92 % -83.7 % -56.56 % -53.58 %


Annual Roi Comment


Definition and Formula of Return on Investment

Other ROI Ratios
Major Pharmaceutical Preparations Industry Roi Trends and Statistics
Healthcare Sector Return On Investment Statistics
Roi Trends for overall market
KPTI's Roi Ratio versus Major Pharmaceutical Preparations Industry, Healthcare Sector and total Market
Highest Ranking Return On Investment
Lowest Ranking Return On Investment
Subscribers only: Roi for KPTI's Competitors
Subscribers only: Roi for Karyopharm Therapeutics Inc's Suppliers
Subscribers only: Return On Investment for KPTI's Customers

Other Ratios
KPTI's Roa KPTI's Inventory Turnover Ratio KPTI's Growth Rates KPTI's Dividend Statistics
KPTI's Profitability Ratios KPTI's Asset Turnover Ratio KPTI's Dividend Growth
KPTI's Roe KPTI's Valuation Ratios KPTI's Financial Strength Ratios KPTI's Dividend Payout Ratio



Companies with similar Return On Investment at Jun 30 2026, within Healthcare Sector ROI

Date modified: 2026-09-26T07:08:33+00:00



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