Alnylam Pharmaceuticals Inc (ALNY) Return on Investment ROI from the third quarter of 2026 to third quarter of 2025 and for the year 2026, average high and low, overall ranking from Sep 30 2026 to Sep 30 2025 - CSIMarket
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Alnylam Pharmaceuticals Inc   (NASDAQ: ALNY)


Alnylam Pharmaceuticals Inc's ROI from its third quarter of 2026 to the third quarter of 2025 and 5 Year Period

Return on Investment, Quarterly Results, Trends, Rankings, Statistics

What is Alnylam Pharmaceuticals Inc's ROI in the third quarter of 2026?
Alnylam Pharmaceuticals Inc achieved a return on average invested assets (ROI) of 63.14 % in its third quarter of 2026, this is above ALNY's average return on investment of -27.1%.
Alnylam Pharmaceuticals Inc s investments during the 12 months ending in the third quarter of 2026 are valued at $4 billion

ROI has improved compared to 22.7% in the second quarter of 2026, due to net income growth.

Within the Healthcare sector 44 other companies had a higher return on investment. While the total ranking for ROI remained the same, compared to the second quarter of 2026 at no. 427.

Definition and Formula of Return on Investment



Return On Investment (Sep 30 2026)
III. Quarter
(Jun 30 2026)
II. Quarter
(Mar 31 2026)
I. Quarter
(Dec 31 2025)
IV. Quarter
(Sep 30 2025)
III. Quarter
Y / Y Investment Change TTM 25.83 % 14.64 % 16.49 % 19.25 % 17.39 %
Y / Y Net Income Change TTM 2200.08 % - - - -
Investment (TTM) in Millions 5,932 4,046 3,780 3,500 3,643
Return On Investment (TTM) 63.14 % 22.7 % 16.92 % 10.98 % 3.45 %
ALNY's Overall Ranking # 427 # 427 # 556 # 1756 #
Seq. Investment Change TTM 15.29 % 3.29 % 2.34 % 3.25 % 5.04 %
Seq. Net Income Change TTM 220.65 % 38.63 % 57.7 % 228.12 % -
Net Income (TTM) in Millions 2,724 850 613 389 118




Return On Investment ALNY's Ranking
Within: No.
Industry # 22
Sector # 45
Overall # 427

Return On Investment Statistics
High Average Low
22.1 %
-27.1 %
-61.18 %
(Jun 30 2026)   (Mar 31 2014)



  News about Alnylam Pharmaceuticals Inc Return on Investment ROI

RNAi Revolution Alnylam’s Qfitlia Approval Marks a New Horizon for Hemophilia and Beyond,

March 28, 2025

In a groundbreaking development that promises to redefine treatment standards, Alnylam Pharmaceuticals, Inc. has recently achieved a significant milestone in the realm of RNA interference (RNAi) therapeutics. The U.S. Food and Drug Administration (FDA) has granted approval for Qfitlia (fitusiran), marking it as the first siRNA therapeutic approved for the treatment of Hemophilia A and B. This approval not only represents a major step forward for patients grappling with these conditions but also underscores Alnylam s position as a leader in the innovative field of RNAi therapeutics. Qfitlia: A Game-Changer for Hemophilia Treatment Hemophilia, a genetic disorder that impedes the blood s ability to clot, has long posed treatment challenges, particularly for those suffering from Hemophilia A and B. Traditionally, treatment regimens have involved regular infusions of clotting factor concentrates. However, the recent FDA approval of Qfitlia introduces a new paradigm by targeting antithrombin, a protein that inhibits clot formation. By lowering antithrombin levels, Qfitlia aims to promote thrombin generation, ultimately rebalancing hemostasis and reducing the frequency of bleeding episodes in patients.

Navigating Innovation Alnylams RNAi Breakthrough Amidst Financial Struggles,

November 18, 2024

Breakthrough in RNAi Therapeutics: Alnylam s Nucresiran Shows Promise Amid Financial HurdlesIn an exciting development for the medical community, Alnylam Pharmaceuticals, Inc. a leader in RNAi therapeutics, has announced promising interim results from the Phase 1 study of their next-generation drug, nucresiran, at the American Heart Association Scientific Sessions 2024. These results have brought new hope in the treatment of transthyretin (ATTR) amyloidosis, a rare but severe condition characterized by the build-up of abnormal proteins, leading to organ damage. Significant Clinical Milestone The data presented in Chicago highlighted the effectiveness of a single dose of nucresiran in achieving a rapid knockdown of TTR (transthyretin), with effects sustained up to six months post-treatment. This outcome underscores the drug s potential in altering the disease course and improving patient outcomes. ATTR amyloidosis has long been a challenging condition with limited therapeutic options, and the prolonged efficacy of nucresiran could signify a meaningful advancement.






Financial Statements
Alnylam Pharmaceuticals Inc's III. Quarter Investments $ 5,932 Millions ALNY's Balance sheet
Alnylam Pharmaceuticals Inc's III. Quarter Income $ 2,167 Millions Quarterly ALNY's Income Statement
ALNY's Income by Division See ALNY's Income by Division


ALNY Annual Return On Investment (Dec 31 2025)
2025
(Dec 31 2024)
2024
(Dec 31 2023)
2023
(Dec 31 2022)
2022
(Dec 31 2021)
2021
Total Investments in Millions 3,500 3,054 2,862 2,778 2,948
Y / Y Investment Growth 14.61 % 6.69 % 3.01 % -5.74 % 4.46 %
Net Income in Millions 314 -278 -440 -1,131 -853
Y / Y Net Income Growth - - - - -
Annual Return On Investment 8.96 % -9.11 % -15.38 % -40.71 % -28.93 %


Annual Roi Comment
In the fiscal year 2025 ROI improved to 8.96 % compared to the prior year, due to net income growth.

Definition and Formula of Return on Investment

Other ROI Ratios
Major Pharmaceutical Preparations Industry Roi Trends and Statistics
Healthcare Sector Return On Investment Statistics
Roi Trends for overall market
ALNY's Roi Ratio versus Major Pharmaceutical Preparations Industry, Healthcare Sector and total Market
Highest Ranking Return On Investment
Lowest Ranking Return On Investment
Subscribers only: Roi for ALNY's Competitors
Subscribers only: Roi for Alnylam Pharmaceuticals Inc's Suppliers
Subscribers only: Return On Investment for ALNY's Customers

Other Ratios
ALNY's Roa ALNY's Inventory Turnover Ratio ALNY's Growth Rates ALNY's Dividend Statistics
ALNY's Profitability Ratios ALNY's Asset Turnover Ratio ALNY's Dividend Growth
ALNY's Roe ALNY's Valuation Ratios ALNY's Financial Strength Ratios ALNY's Dividend Payout Ratio



Companies with similar Return On Investment at Sep 30 2026, within Healthcare Sector ROI
Indivior Pharmaceuticals Inc   108.22 %
Exelixis Inc   75.01 %
Ironwood Pharmaceuticals inc   68.68 %
Rigel Pharmaceuticals Inc  68.50 %
Alnylam Pharmaceuticals Inc   63.14 %
Idexx Laboratories Inc  52.51 %
Aurinia Pharmaceuticals Inc   45.04 %
Nurix Therapeutics Inc   44.12 %
Medpace Holdings Inc   41.14 %
Rallybio Corporation  36.04 %
Eli Lilly And Company  32.00 %
Caredx Inc   30.65 %
Zevra Therapeutics Inc   29.88 %
Acadia Pharmaceuticals Inc   26.89 %
Standard Biotools Inc   23.91 %
Iradimed Corporation  22.98 %
Corcept Therapeutics Inc  22.08 %
Resmed Inc   21.10 %
Alector Inc   20.83 %
Chemed Corporation  20.46 %
Halozyme Therapeutics Inc   19.64 %
Pro dex Inc   19.11 %
Dexcom Inc   18.92 %
Illumina Inc   18.74 %
Denali Therapeutics Inc   17.88 %
West Pharmaceutical Services Inc   17.65 %
Healthcare Services Group Inc   17.18 %
Neurocrine Biosciences Inc   16.94 %
Krystal Biotech Inc   16.91 %
Vertex Pharmaceuticals Inc  16.63 %


Date modified: 2026-10-30T17:00:10+00:00



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