Upstream Bio Inc's ROI from its second quarter of 2026 to the second quarter of 2025 and 5 Year Period

Return on Investment, Quarterly Results, Trends, Rankings, Statistics

What is Upstream Bio Inc's ROI in the second quarter of 2026?
Upstream Bio Inc recorded a cumulative net loss of $-157 million during 12 months ending in the second quarter of 2026, resulting in a negative return on investment (ROI) of -48.33%.

Within the Healthcare sector 459 other companies had a higher return on investment. While return on investment, the total ranking has deteriorated compared to the first quarter of 2026 from 3587 to 3673.

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Return On Investment	(Jun 30 2026) II. Quarter	(Mar 31 2026) I. Quarter	(Dec 31 2025) IV. Quarter	(Sep 30 2025) III. Quarter	(Jun 30 2025) II. Quarter
Y / Y Investment Change TTM	-16.39 %	-5.37 %	47.5 %	185.67 %	312.47 %
Y / Y Net Income Change TTM	-	-	-	-	-
Investment (TTM) in Millions	271	304	340	379	410
Return On Investment (TTM)	-48.33 %	-43.74 %	-36.41 %	-28.78 %	-27.12 %
UPB's Overall Ranking	# 3673	# 3587	# 3247	# 3333	# 2827
Seq. Investment Change TTM	-9.65 %	-9.03 %	-7.66 %	10.17 %	2.25 %
Seq. Net Income Change TTM	-	-	-	-	-
Net Income (TTM) in Millions	-157	-157	-143	-123	-105

UPB Company Profile >> Back to UPB Roi Comparisons >> See Annual UPB Return On Investment

Return On Investment UPB's Ranking
Within:	No.
Industry	# 191
Sector	# 460
Overall	# 3673

Return On Investment Statistics
High	Average	Low
-21.05 %	-32.25 %	-48.33 %
(Mar 31 2025)		(Jun 30 2026)

Financial Statements
Upstream Bio Inc's II. Quarter Investments	$ 271 Millions	UPB's Balance sheet
Upstream Bio Inc's II. Quarter Income	$ -40 Millions	Quarterly UPB's Income Statement
UPB's Income by Division		See UPB's Income by Division

UPB Annual Return On Investment	(Dec 31 2025) 2025	(Dec 31 2024) 2024
Total Investments in Millions	340	471	0	0	0
Y / Y Investment Growth	-27.74 %	-	-	-	-
Net Income in Millions	-143	-63	0	0	0
Y / Y Net Income Growth	-	-	-	-	-
Annual Return On Investment	-42.15 %	-13.34 %	-	-	-

Annual Roi Comment

Definition and Formula of Return on Investment

Other ROI Ratios
Major Pharmaceutical Preparations Industry Roi Trends and Statistics
Healthcare Sector Return On Investment Statistics
Roi Trends for overall market
UPB's Roi Ratio versus Major Pharmaceutical Preparations Industry, Healthcare Sector and total Market
Highest Ranking Return On Investment
Lowest Ranking Return On Investment
Subscribers only: Roi for UPB's Competitors
Subscribers only: Roi for Upstream Bio Inc's Suppliers
Subscribers only: Return On Investment for UPB's Customers

Other Ratios
UPB's Roa	UPB's Inventory Turnover Ratio	UPB's Growth Rates	UPB's Dividend Statistics
	UPB's Profitability Ratios	UPB's Asset Turnover Ratio	UPB's Dividend Growth
UPB's Roe	UPB's Valuation Ratios	UPB's Financial Strength Ratios	UPB's Dividend Payout Ratio

Companies with similar Return On Investment at Jun 30 2026, within Healthcare Sector

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Date modified: 2026-09-26T07:43:05+00:00

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