| Business Segment |
Profit Margin |
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| U S |
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| International |
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| Innovative Medicine |
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| Innovative Medicine U S |
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| Innovative Medicine International |
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| Innovative Medicine Immunology |
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| Innovative Medicine Immunology U S |
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| Innovative Medicine Immunology International |
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| Innovative Medicine Immunology SIMPONI SIMPONI ARIA |
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| Innovative Medicine Immunology SIMPONI SIMPONI ARIA U S |
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| Innovative Medicine Immunology SIMPONI SIMPONI ARIA International |
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| Innovative Medicine Immunology STELARA |
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| Innovative Medicine Immunology STELARA U S |
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| Innovative Medicine Immunology STELARA International |
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| Innovative Medicine Immunology OTHER IMMUNOLOGY |
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| Innovative Medicine Immunology OTHER IMMUNOLOGY U S |
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| Innovative Medicine Infectious Diseases |
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| Innovative Medicine Infectious Diseases U S |
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| Innovative Medicine Infectious Diseases International |
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| Innovative Medicine Infectious Diseases EDURANT rilpivirine |
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| Innovative Medicine Infectious Diseases EDURANT rilpivirine U S |
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| Innovative Medicine Infectious Diseases EDURANT rilpivirine International |
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| Innovative Medicine Infectious Diseases PREZISTA PREZCOBIX REZOLSTA SYMTUZA |
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| Innovative Medicine Infectious Diseases PREZISTA PREZCOBIX REZOLSTA SYMTUZA U S |
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| Innovative Medicine Infectious Diseases PREZISTA PREZCOBIX REZOLSTA SYMTUZA International |
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| Innovative Medicine Infectious Diseases OTHER INFECTIOUS DISEASES |
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| Innovative Medicine Infectious Diseases OTHER INFECTIOUS DISEASES U S |
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| Innovative Medicine Infectious Diseases OTHER INFECTIOUS DISEASES International |
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| Innovative Medicine Neuroscience |
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| Innovative Medicine Neuroscience U S |
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| Innovative Medicine Neuroscience International |
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| Innovative Medicine Neuroscience INVEGA SUSTENNA XEPLION INVEGA TRINZA TREVICTA |
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| Innovative Medicine Neuroscience INVEGA SUSTENNA XEPLION INVEGA TRINZA TREVICTA U S |
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| Innovative Medicine Neuroscience INVEGA SUSTENNA XEPLION INVEGA TRINZA TREVICTA International |
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| Innovative Medicine Neuroscience SPRAVATO |
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| Innovative Medicine Neuroscience SPRAVATO U S |
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| Innovative Medicine Neuroscience SPRAVATO International |
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| Innovative Medicine Neuroscience OTHER NEUROSCIENCE |
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| Innovative Medicine Neuroscience OTHER NEUROSCIENCE U S |
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| Innovative Medicine Neuroscience OTHER NEUROSCIENCE International |
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| Innovative Medicine Oncology |
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| Innovative Medicine Oncology U S |
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| Innovative Medicine Oncology International |
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| Innovative Medicine Oncology CARVYKTI |
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| Innovative Medicine Oncology CARVYKTI U S |
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| Innovative Medicine Oncology CARVYKTI International |
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| Innovative Medicine Oncology DARZALEX |
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| Innovative Medicine Oncology DARZALEX U S |
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| Innovative Medicine Oncology DARZALEX International |
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| Innovative Medicine Oncology ERLEADA |
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| Innovative Medicine Oncology ERLEADA U S |
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| Innovative Medicine Oncology ERLEADA International |
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| Innovative Medicine Oncology IMBRUVICA |
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| Innovative Medicine Oncology IMBRUVICA U S |
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| Innovative Medicine Oncology IMBRUVICA International |
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| Innovative Medicine Oncology Tecvayli |
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| Innovative Medicine Oncology Tecvayli U S |
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| Innovative Medicine Oncology Tecvayli International |
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| Innovative Medicine Pulmonary Hypertension |
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| Innovative Medicine Pulmonary Hypertension U S |
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| Innovative Medicine Pulmonary Hypertension International |
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| Innovative Medicine Pulmonary Hypertension UPTRAVI |
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| Innovative Medicine Pulmonary Hypertension UPTRAVI U S |
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| Innovative Medicine Pulmonary Hypertension UPTRAVI International |
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| Innovative Medicine Pulmonary Hypertension Other |
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| Innovative Medicine Pulmonary Hypertension Other U S |
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| Innovative Medicine Pulmonary Hypertension Other International |
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| Innovative Medicine Cardiovascular Metabolism Other |
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| Innovative Medicine Cardiovascular Metabolism Other U S |
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| Innovative Medicine Cardiovascular Metabolism Other International |
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| Innovative Medicine Cardiovascular Metabolism Other Other |
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| Innovative Medicine Cardiovascular Metabolism Other Other U S |
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| Innovative Medicine Cardiovascular Metabolism Other Other International |
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| Innovative Medicine Cardiovascular Metabolism Other XARELTO |
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| Innovative Medicine Cardiovascular Metabolism Other XARELTO U S |
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| MEDTECH |
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| MEDTECH U S |
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| MEDTECH International |
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| MEDTECH Cardiovascular |
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| MEDTECH Cardiovascular U S |
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| MEDTECH Cardiovascular International |
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| MEDTECH ELECTROPHYSIOLOGY |
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| MEDTECH ELECTROPHYSIOLOGY U S |
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| MEDTECH ELECTROPHYSIOLOGY International |
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| MEDTECH ABIOMED |
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| MEDTECH ABIOMED U S |
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| MEDTECH ABIOMED International |
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| MEDTECH Shockwave |
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| MEDTECH Shockwave U S |
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| MEDTECH Shockwave International |
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| MEDTECH Other Cardiovascular |
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| MEDTECH Other Cardiovascular U S |
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| MEDTECH Other Cardiovascular International |
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| MEDTECH Orthopaedics |
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| MEDTECH Orthopaedics U S |
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| MEDTECH Orthopaedics International |
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| MEDTECH Orthopaedics HIPS |
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| MEDTECH Orthopaedics HIPS U S |
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| MEDTECH Orthopaedics HIPS International |
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| MEDTECH Orthopaedics KNEES |
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| MEDTECH Orthopaedics KNEES U S |
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| MEDTECH Orthopaedics KNEES International |
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| MEDTECH Orthopaedics TRAUMA |
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| MEDTECH Orthopaedics TRAUMA U S |
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| MEDTECH Orthopaedics TRAUMA International |
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| MEDTECH Surgery |
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| MEDTECH Surgery U S |
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| MEDTECH Surgery International |
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| MEDTECH Surgery ADVANCED |
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| MEDTECH Surgery ADVANCED U S |
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| MEDTECH Surgery ADVANCED International |
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| MEDTECH Surgery GENERAL |
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| MEDTECH Surgery GENERAL U S |
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| MEDTECH Surgery GENERAL International |
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| MEDTECH Vision |
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| MEDTECH Vision U S |
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| MEDTECH Vision International |
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| MEDTECH Vision CONTACT LENSES OTHER |
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| MEDTECH Vision CONTACT LENSES OTHER U S |
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| MEDTECH Vision CONTACT LENSES OTHER International |
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| MEDTECH Vision SURGICAL |
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| MEDTECH Vision SURGICAL U S |
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| MEDTECH Vision SURGICAL International |
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| United States |
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| Europe |
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| Western Hemisphere excluding U S |
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| Asia-Pacific Africa |
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| Innovative Medicine Oncology RYBREVANT LAZCLUZE |
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| Innovative Medicine Oncology RYBREVANT LAZCLUZE U S |
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| Innovative Medicine Oncology RYBREVANT LAZCLUZE International |
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| Innovative Medicine Oncology TALVEY |
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| Innovative Medicine Oncology TALVEY U S |
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| Innovative Medicine Oncology TALVEY International |
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| Innovative Medicine Oncology Other Oncology |
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| Innovative Medicine Oncology Other Oncology U S |
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| Innovative Medicine Oncology Other Oncology International |
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| Innovative Medicine Neuroscience CAPLYTA |
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| Innovative Medicine Neuroscience CAPLYTA U S |
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| Innovative Medicine Pulmonary Hypertension OPSUMIT OPSYNVI |
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| Innovative Medicine Pulmonary Hypertension OPSUMIT OPSYNVI U S |
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| Innovative Medicine Pulmonary Hypertension OPSUMIT OPSYNVI International |
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| Innovative Medicine Immunology Tremfya |
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| Innovative Medicine Immunology Tremfya U S |
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| Innovative Medicine Immunology Tremfya International |
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| Innovative Medicine Immunology Remicade |
|
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| Innovative Medicine Immunology Remicade U S |
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| Innovative Medicine Immunology Remicade International |
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| Innovative Medicine Immunology OTHER IMMUNOLOGY International |
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| Innovative Medicine Neuroscience CONCERTA Methylphenidate |
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| Innovative Medicine Neuroscience CONCERTA Methylphenidate U S |
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| Innovative Medicine Neuroscience CONCERTA Methylphenidate International |
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| Innovative Medicine Total PH ID CVM Other |
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| Innovative Medicine Total PH ID CVM Other U S |
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| Innovative Medicine Total PH ID CVM Other International |
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| MEDTECH Orthopaedics SPINE OTHER |
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| MEDTECH Orthopaedics SPINE OTHER U S |
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| MEDTECH Orthopaedics SPINE OTHER International |
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